Chen Fei

Associate Professor at Xiangya School of Pharmacy, Central South University, master's supervisor, and excellent young scientist of Hunan Province . Currently in charge of the National Natural Science Foundation of China Youth Project, the Hunan Provincial Natural Science Foundation Excellent Young Scientist Project, the Hunan Provincial Department of Education Excellent Young Scientist Project, the Hunan Provincial Natural Science Foundation Youth Project, and the Central South University Graduate Education and Teaching Reform Project. As a core member, he participated in the Sino-German cooperation and exchange project, two National Natural Science Foundation projects, and the Central South University Frontier Interdisciplinary Project. He graduated from Tongji School of Pharmacy, Huazhong University of Science and Technology with a bachelor's degree; graduated from the National Center for Nanoscience and Technology with a master's degree, under the tutelage of Professor Xingjie Liang; graduated from the Max Planck Institute for Polymer Research, Germany, under the tutelage of Professor Kartherina Landfester ; and worked as a postdoctoral fellow at the Institute of Physiology and Pathology, Medical School, University of Münster, Germany, with Professor Seraphine Wegner as his co-supervisor . He has joined the team of Professor Zeng Wenbin , and his main research direction is: for a series of key scientific issues in analysis, detection and disease treatment in the environment and life sciences, he has carried out research work on the innovative construction of molecular probes for biological imaging, disease diagnosis and treatment.

work experience

2024.3-Present Project 1 | Seconded by the Department of Science and Education of the National Health Commission 

2020.12-Present Xiangya School of Pharmacy | Central South University Associate Researcher

2019.11-2020.10 Institute of Physiology and Pathology | Postdoctoral Fellow, Medical School, University of Münster, Germany 

2019.9-2019.10 Postdoctoral fellow, Max Planck Institute for Polymer Research, Germany 

Courses 

Undergraduates: Medicinal Chemistry, Bioorganic Chemistry, Medicinal Chemistry Experiment 

Graduate students: Selected Topics in Advanced Medicinal Chemistry

Academic Achievements

近年在国际期刊上共发表50余篇sci论文，H因子20。其中以第一/通讯作者在Adv. Funct. Mater.、Acta Pharm. Sin. B.、Chem. Eng. J.、Matter、Biomater. Res.、ACS Sens.、ACS Appl. Mater. Interfaces、ACS Synth. Biol.、Mol. Pharmaceutics等发表20篇，其中NI指数期刊1篇，影响因子>10的文章共6篇，影响因子>15的文章共3篇。获得国内授权发明专利4项。参编英文专著1部。担任《Exploration》，《iRiadiology》青年编委。担任《ACS Appl. Mater. Interfaces》，《ACS Appl. Nano Mater. Interfaces》《中国药师》等期刊审稿专家。

Personal Links

https://orcid.org/my-orcid?orcid=0000-0002-7600-1945

https://www.researchgate.net/profile/Fei-Chen-106

https://scholar.google.com.hk/citations?user=e_NViRYAAAAJ&hl=de

Representative Articles

1.      Liu, X., Ren, Y., Fan, D., Huang, S., Ma, Y., Ding, J., Luo, Z., Chen, F.,* Zeng, W. * Shining Light on Multidrug-Resistant Bacterial Infections: Rational Design of Multifunctional Organosilver-Based AIEgen Probes as Light-Activated Theranostics for Combating Biofilms and Liver Abscesses. Advanced Functional Materials 2023, 2304974. （IF= 19.0）

2.      Fan, D.; Liu, X.; Ren, Y.; Luo, Z.; Li, Y.; Dong, J.; Wegner, S. V.; Chen, F.;*  Zeng, W. * Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy. Acta Pharmaceutica Sinica B 2024, 14(4), 1759-1771（IF= 14.5）

3.      Zheng, F., Ma, Y., Ding, J., Huang, S., Zhang, S., Huang, X., Feng, B., Zeng, H., Chen, F., * Zeng, W. * Ratiometric and discriminative visualization of autophagic processes with a novel dual-responded lysosome-specific fluorescent probe. Biomaterials Research 2023, 27(1), 66-77.（IF= 11.3）

4.      Feng, B.; Ma, Y.; Zheng, F.; Huang, X.; Feng, X.; Zhang, K.; Liu, L.; Chen, F.;* Zeng, W., * Development of near-infrared lysosomal pH-activatable fluorescent probe for real-time visualization of autophagy progression. Chemical Engineering Journal 2023, 464, 142554.（IF= 15.1）

5.      Huang, X.;¹ Chen, F.;¹ Ma, Y.; Zheng, F.; Fang, Y.; Feng, B.; Huang, S.; Zeng, H.; Zeng, W., De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation. Biomaterials Research 2023, 27 (1), 20-37.（IF= 11.3）

6.      Liu, X.; Fan, D.; Ren, Y.; Huang, S.; Ding, J.; Liu, M.; Wegner, S. V.; Hou, J.; Rong, P.; Chen, F.;* Zeng, W., * Photo-Activable Organosilver Nanosystem Facilitates Synergistic Cancer Theranostics. ACS Appl. Mater. Interfaces 2023, 15 (1), 711-722.（IF= 9.5）

7.      Fan, D.; Liu, X.; Ren, Y.; Bai, S.; Li, Y.; Luo, Z.; Dong, J.; Chen, F.;* Zeng, W., *Functional insights to the development of bioactive material for combating bacterial infections. Front. Bioeng. Biotechnol. 2023, 11, 1186637.（IF= 5.7）

8.      Chen, F.; Dong, J.; Sun, W.; Di Iorio, D.; Wegner, S. V.; Zeng, W. Editorial: Construction of smart materials for biomedical application. Frontiers in Bioengineering and Biotechnology 2023, 11, 1278243. doi: 10.3389/fbioe.2023.1278243.（IF= 5.7）

9.      Chen, F., Zeng, W., and Wegner, S. V. (2022). Ultrasound-activated bacteria with thermostat controls as living therapeutics. Matter 5, 2416–2419. (IF= 18.9)

10.   Liu, X.; Fan, D.; Feng, X.; Zheng, Y.; Wegner, S. V.; Liu, M.; Chen, F.;* Zeng, W. * (2022). Breaching Bacterial Biofilm Barriers: Efficient Combinatorial Theranostics for Multidrug-Resistant Bacterial Biofilms with a Novel Penetration-Enhanced AIEgen Probe. ACS Appl. Mater. Interfaces 14 (37), 41671-41683.（IF= 9.5）

11.   Zheng, F.; Huang, X.; Ding, J. P.; Bi, A.; Wang, S.; Chen, F.; * Zeng, W., * NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics. Frontiers in Chemsitry 2022, 10 (1), 1-23.（IF= 5.5）

12.   Song, R.; Ma, Y.; Bi, A.; Feng, B.; Huang, L.; Huang, S.; Huang, X.; Yin, D.; Chen, F.; * Zeng, W., * Highly selective and sensitive detection of arsenite ions(iii) using a novel tetraphenylimidazole-based probe. Analytical Methods 2021, 13 (42), 5011-5016. （IF= 3.1）

13.   Chen, F.; Wegner, S. V., Photoswitchable bacteria-bacteria adhesions enable the control of multicellular bacterial communities by using blue light. ACS Synthetic Biology 2020, 9 (5), 1169–1180. （IF= 4.7）

14.   Chen, F.; Rachel L. Warnock, Jan Roelof Van der Meer,Wegner, S. V., Bioluminescence-Triggered Photoswitchable Bacterial Adhesions enable Higher Sensitivity and Dual-readout Bacterial Biosensors for Mercury. ACS Sensors 2020, 5 (7), 2205–2210. (IF= 8.9)

15.   Chen, F.; Ricken, J.; Xu, D.; Wegner, S. V., Bacterial Photolithography: Patterning Escherichia coli Biofilms with High Spatial Control Using Photocleavable Adhesion Molecules. Advanced Biosystems 2019, 3 (3), 1800269. （IF= 3.7）

16.   Chen, F.; Wegner, S. V., Implementation of Blue Light Switchable Bacterial Adhesion for Design of Biofilm. Bio-protocol, 2018, 8 (12), e2893.

17.   Chen, F.; Wegner, S. V., Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms. ACS Synthetic Biology 2017, 6 (12), 2170-2174.（IF=4.7）

18.   Zhao, Y.;¹ Chen, F.;¹ Pan, Y.; Li, Z.; Xue, X.; Okeke, C. I.; Wang, Y.; Li, C.; Peng, L.; Wang, P. C.; Ma, X.; Liang, X. J., Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance. ACS applied materials & interfaces 2015, 7 (34), 19295-305.（IF= 9.5）

19.   Chen, F.; Zhao, Y.; Pan, Y.; Xue, X.; Zhang, X.; Kumar, A.; Liang, X. J., Synergistically Enhanced Therapeutic Effect of a Carrier-Free HCPT/DOX Nanodrug on Breast Cancer Cells through Improved Cellular Drug Accumulation. Molecular pharmaceutics 2015, 12 (7), 2237-44.（IF= 4.9）

20.   Kumar, A.;¹ Chen, F.;¹ Mozhi, A.; Zhang, X.; Zhao, Y.; Xue, X.; Hao, Y.; Zhang, X.; Wang, P. C.; Liang, X. J., Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation. Nanoscale 2013, 5 (18), 8307-8325.（IF= 6.7）