Quantitative measurement of acute myocardial infarction cardiac biomarkers by “All-in-One” immune microfluidic chip for early diagnosis of myocardial infarction
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Release time:2025-02-16 Impact Factor:4.3 DOI number:10.1016/j.saa.2024.124256 Affiliation of Author(s):Xiangya School of Pharmaceutical Sciences in Central South University, Changsha, Hunan, China Journal:Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Place of Publication:英国 Key Words:Immune microfluidic chipAMI cardiac biomarkers Myocardial infarctionQuantitative analysisAll-in-One Abstract:Acute myocardial infarction (AMI) is a life-threatening condition with a narrow treatment window, necessitating rapid and accurate diagnostic methods. We present an “all-in-one” convenient and rapid immunoassay system that combines microfluidic technology with a colloidal gold immunoassay. A degassing-driven chip replaces a bulky external pump, resulting in a user-friendly and easy-to-operate immunoassay system. The chip comprises four units: an inlet reservoir, an immunoreaction channel, a waste pool, and an immunocomplex collection chamber, allowing single-channel flow for rapid and accurate AMI biomarker detection. In this study, we focused on cardiac troponin I (cTnI). With a minimal sample of just 4 μL and a total detection time of under 3 min, the chip enabled a quantitative visual analysis of cTnI concentration within a range of 0.5 ∼ 60.0 ng mL−1. This all-in-one integrated microfluidic chip with colloidal gold immunoassay offers a promising solution for rapid AMI diagnosis. The system's portability, small sample requirement, and quantitative visual detection capabilities make it a valuable tool for AMI diagnostics. Co-author:H. Li, Q. Li, R. Sun, X. Zhang, D. Zhang, Q. Zhu First Author:Z. Zeng Indexed by:Journal paper Correspondence Author:C. Chen Discipline:Medicine First-Level Discipline:Pharmaceutical Science Document Type:电子版 Volume:315 Page Number:124256 ISSN No.:1873-3557 Translation or Not:no Date of Publication:2024-04-10 -
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