2013年本科毕业于湖南农业大学生物技术专业；2020年博士毕业于北京师范大学心理学部认知神经科学，师从舒友生教授；同年加入复旦大学脑科学转化研究院从事博士后研究，获得上海市“求索杰出青年—博士后”和“超级博士后”等人才称号。2024年9月加入中南大学生命科学学院，致力于从突触和环路的角度探讨脑功能机制及脑疾病发病机理。主持国家自然科学基金面上项目、青年项目（C类），湖南省重点研发项目、省自然青年项目（B类）[原优青项目]，长沙市自然科学基金项目等。参与国家自然科学基金重点项目3项、科技部科技创新2030-重大项目、湖南省自然科学基金重点项目等。以第一作者/通讯作者（含共同）身份发表论文于Neuron、Nature Communications、Molecular Psychiatry，与国内外同行开展合作研究的成果发表在Nature Biomedical Engineering、Science Advances、eLife等国际权威杂志上。获得中国神经科学学会颁发的JNS Travel Awards-2020和张香桐神经科学优秀研究生论文奖（2021）。

核心论文（按时间倒序）：

Xiran Liu, Dengfeng Liu, Bingyu Long, Yichun Zhang, Fan Xia, Jia-Da Li, Suixin Deng. Increased activity of DRD1-MSNs in dorsolateral striatum underlies Cry1Δ11 mutation-induced repetitive behaviors. Translational Psychiatry, 2026.

Zongyi Xu, Wei Duan, Shuyu Yuan, Xiaoxue Zhang, Chong You, Jin-Tai Yu, Jian Wang, Jia-Da Li, Suixin Deng#, Yousheng Shu#. Deep brain stimulation alleviates Parkinsonian motor deficits through desynchronizing GABA release in mice. Nature Communications, 2025, 16(1):3726. (#Co-corresponding author)

Yichun Zhang, Xin Li, Yong Liu, Xiangyu Li, Dengfeng Liu, Qingyun Han, Xiran Liu, Xuyi Wang#, Jia-Da Li#, Suixin Deng#. Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice. Behavioral and Brain Functions, 2025, 21(1):22. (#Co-corresponding author)

Dixian Wang*, Zhaojun Dong*, Suixin Deng*, Yingming Tian, Yujie Xiao, Xinran Li, Xiaoru Ma, Liang Li, Pengxiao Li, Huizhong Chang, Longqi Liu, Fan Wang, Yang Wu, Xiang Gao, Shuangshuang Zheng, Huimin Gu, Yanan Zhang, Jianbin Wu, Fan Wu, Yonglin Peng, Xiaowen Zhang, Renya Zhan, Lixia Gao, Qiming Sun, Xing Guo, Xiaodong Zhao, Jianhong Luo, Ruhong Zhou, Lei Han#, Yousheng Shu#, Jingwei Zhao#. GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21. Nature Communications, 2023, 14(1): 7476. (*Co-first author)

Xue Chen*, Suixin Deng*, Wenchao Wang*, Stefania Castiglione*, Zilei Duan*, Lei Luo, Francesca Cianci, Xiaoxue Zhang, Jianglei Xu, Hao Li, Jizong Zhao, Peter Muiruri Kamau, Zhiye Zhang, James Mwangi, Jiali Li, Yousheng Shu#, Xintian Hu#, Michele Mazzanti#, Ren Lai#. Human Antimicrobial Peptide LL-37 Contributes to Alzheimer’s Disease Progression. Molecular Psychiatry, 2022, 27(11): 4790-4799. (*Co-first author)

Suixin Deng, Junlong Li, Quansheng He, Xiaoxue Zhang, Jie Zhu, Liang Li, Zhen Mi, Xiufeng Yang, Man Jiang, Qiang Dong, Ying Mao, Yousheng Shu. Regulation of recurrent inhibition by asynchronous glutamate release in neocortex. Neuron, 2020, 105(3): 522-533.

邓穗馨，舒友生. 大脑皮质神经元及其网络的兴奋. 中国药理学与毒理学杂志, 2017, 31(11):1033-1044.

合作论文（按时间倒序）：

Wei Duan, Zongyi Xu, Suixin Deng, Wei Ke, Xiaoxue Zhang, Shuyu Yuan, Kexin Wang, Liang Li, Shidi Wang, Yuandong Liu, Wanrui Li, Wenqing Shui, Yang Tian, Haidong D. Lu, Hui Guo#, Quansheng He#, Yousheng Shu#. Depolarization block paradoxically drives surges ofneurotransmitter release during seizure activity. Epilepsia, 2026.

Wei Ke*, Shuxuan Lyu*, Mengmeng Jin*, Shaoqing Jiao*, Liang Li, Heyuan Zhang, Kexin Ling, Cuiping Tian, Yiquan Song, Liu Chen, Quansheng He, Yujie Xiao, Suixin Deng, Liu Fan, Huawei Mu, Hui Yang, Hua-Tai Xu, Hao Wang, Ai-Hui Tang, Jiajie Peng#, Jie He#, Hui Guo#, Yousheng Shu#. Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures. Nature Communications, 2026, 17(1):6330.

Xiangyu Li*, Ibrahim Bader*, Xin Li, Renbin Lu, Dengfeng Liu, Zhiheng Chen, Suixin Deng, Yousheng Shu, Huadie Liu#, Jing Zhang#, Jia-Da Li#. Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP. Molecular Psychiatry, 2025, 31(2):895-907.

Ruikai Chai*, Nawen Wang*, Jinlu Nie*, Zongyi Xu*, Shuqian Zhang, Suixin Deng, Rongxin Wang, Mu Li, Xinyi Gao, Ruijie Geng, Haibin Li, Lei Li, Hebi Wu, Zhiming Li, Tian-Lin Cheng, Xiao-Hong Xu, Yousheng Shu#, Huilin Hong#, Xiao Huang#, Weisheng Wang#. Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience. Nature Communications, 2025, 16(1):4885.

Qianqian Ge*, Jiachao Yang*, Fei Huang*, Xinyue Dai*, Chao Chen*, Jingxin Guo, Mi Wang, Mengyue Zhu, Yijie Shao, Yuxian Xia, Yu Zhou, Jieqiao Peng, Suixin Deng, Jiachen Shi, Yiqi Hu, Huiying Zhang, Yi Wang, Xiaoqun Wang, Xiao-Ming Li, Zhong Chen, Yousheng Shu, Jun-Ming Zhu, Jianmin Zhang, Ying Shen, Shumin Duan, Shengjin Xu, Li Shen, Jiadong Chen. Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy. The Journal of Clinical Investigation, 2025, 135(5):e188942.

Jinhong Xu*, Shi Fang*, Suixin Deng, Huijuan Li, Xiaoning Lin, Yongheng Huang, Sangmi Chung, Yousheng Shu, Zhicheng Shao. Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nature Biomedical Engineering, 2023, 7(3): 253-269.

Nancy R. Mack, Suixin Deng, Sha-Sha Yang, Yousheng Shu#, Wen-Jun Gao#. Prefrontal Cortical Control of Anxiety: Recent Advances. The Neuroscientist, 2023, 29(4):488-505.

Yang He*, Taohui Liu*, Quansheng He*, Wei Ke, Xiaoyu Li, Jinjin Du, Suixin Deng, Zhenfeng Shu, Jialin Wu, Baozhi Yang, Yuqing Wang, Ying Mao, Yanxia Rao, Yousheng Shu#, Bo Peng#. Microglia facilitate and stabilize the response to general anesthesia via modulating the neuronal network in a brain region-specific manner. Elife, 2023, 12:RP92252.

Dengfeng Liu, Zhengyu Xie, Panyang Gu, Xiangyu Li, Yichun Zhang, Xinying Wang, Zhiheng Chen, Suixin Deng, Yousheng Shu, Jia-Da Li. Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling. JCI Insight, 2023, 8(16):e170434.

René Wilbers, Anna A. Galakhova, Stan L.W. Driessens, Tim S. Heistek, Verjinia D. Metodieva, Jim Hagemann, Djai B. Heyer, Eline J. Mertens, Suixin Deng, Sander Idema, Philip C. de Witt Hamer, David P. Noske, Paul van Schie, Ivar Kommers, Guoming Luan, Tianfu Li, Yousheng Shu, Christiaan P.J. de Kock, Huibert D. Mansvelder#, Natalia A. Goriounova#. Structural and functional specializations of human fastspiking neurons support fast cortical signaling. Science Advances, 2023, 9(41):eadf0708.

Junlong Li, Suixin Deng, Quansheng He, Wei Ke, Yousheng Shu. Asynchronous glutamate release at autapses regulates spike reliability and precision in mouse neocortical pyramidal cells. Cerebral Cortex, 2021, 31(4): 2278-2290.

Bo Wang, Wei Ke, Jing Guang, Guang Chen, Luping Yin, Suixin Deng, Quansheng He, Yaping Liu, Ting He, Rui Zheng, Yanbo Jiang, Xiaoxue Zhang, Tianfu Li, Guoming Luan, Haidong Lu, Mingsha Zhang, Xiaohui Zhang, Yousheng Shu. Firing Frequency Maxima of Fast-Spiking Neurons in Human, Monkey, and Mouse Neocortex. Frontiers in Cellular Neuroscience, 2016, 10:239.

Bo Wang, Luping Yin, Xiaolong Zou, Min Ye, Yaping Liu, Ting He, Suixin Deng, Yanbo Jiang, Rui Zheng, Yun Wang, Mingpo Yang, Haidong Lu, Si Wu, Yousheng Shu. A Subtype of Inhibitory Interneuron with Intrinsic Persistent Activity in Human and Monkey Neocortex. Cell Reports, 2015, 10(9):1450-1458.

主要利用整体/离体电生理学、光/化学遗传学、光纤光度成像、小鼠深部脑刺激、病毒示踪、形态学等技术手段，从分子、突触、环路、行为等多水平来研究脑功能生理调控机制，解析脑疾病状态下神经信号的变化规律，开发或优化神经调控治疗技术。主要研究兴趣包括：

1）突触传递模式对神经元电活动和环路功能的调节作用，及相关医学转化研究。

2）睡眠和节律的神经环路基础，及针对节律紊乱导致的脑疾病的神经调控技术研发。

3）情绪相关神经环路的功能解析和调控，特别关注内在感受器介导的情绪效应及中枢-外周神经交互机制。