Qian Han
Name of Research Group: Nano-Bio Technology Laboratory
Description of Research Group:Biomedical engineering, the most rapidly growing of engineering disciplines from a global perspective, is now playing an irreplaceable role in the enhancement of human lifespan and its quality. At our Nano-Bio Technology Laboratory, we explore multi-disciplinary research and cutting-edge technology so that we bridge medicine and technology. Specifically, we are dedicated to achieving similar success with polypeptide sequencing to what nanopore sequencing has done to DNA so that there will be a possibility that we understand the causes of protein primary structure related diseases better and consequently come up with a solution. Moreover, solid-state nanopores have huge potential in single cell secretion detection because significant clinical biomarkers can be selective thanks to nanopore's adjustable geometry. We are also interested in utilizing electron microscopy and atomic force microscopy in various biomedical applications, such as synthetic biology and virology, to aid clinic treatment.
Team members Introduction:Qian Han, a doctoral student majoring in biomedical engineering and technology in 2022, graduated from Xiamen University majoring in science in June 2022. During her master's degree, she was engaged in the research on the mechanism of fate differentiation of placental trophoblast cells during embryonic development, and skillfully mastered the skills of single cell transcriptome sequencing, ChIP-seq, RNA-seq and other biological data analysis and molecular biology experiments. Email：qianhan0127@126.com Publications: Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation, Exp Cell Res, 2021. Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2, BMC Biol.2020, 18(1): 151.
