Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats

Release time:2016-04-22

Affiliation of Author(s):Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University,

Journal:Journal of Central South University(Medical Scienc

Funded by:Science and Technology Planning Project of Hunan Province, P. R. China (2010CK3014, 2012SK3217).

Abstract:Objective: To investigate the therapeutic mechanism of letrozole, the third-generation aromatase inhibitor, on endometriotic lesions in a rat model and its effect on the apoptosis of ectopic endometrial cells. Conclusion: Letrozole can obviously reduce the size of ectopic implant through decreasing P450arom and COX-2 expression, suppressing the secretion of estrogen, inhibiting the proliferation, and inducing the apoptosis of ectopic implants.

Co-author:FANG Xiaoling*, SU Jinping, GUO Lilu, XIA Xiaomeng

Indexed by:Unit Twenty Basic Research

Discipline:临床医学

Document Type:J

Translation or Not:no

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+letrozole+on+endometrosis+and+apoptosis+of+ectopic+endometrial+cells+in+rats