Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro

Release time:2016-04-22

Affiliation of Author(s):Department of Obstetrics and Gynecology, Second Xiangya Hospital, Central South University,

Teaching and Research Group:妇产科教研室

Journal:Acta Biochim Biophys Sin (Shanghai)

Abstract:Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles before 40 years of age, representing one major cause of female infertility. Stem cells provide the possibility of a potential treatment for POF. In this study, rat embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were co-cultured with granulosa cells (GCs) to differentiate to GC-like cells. Thus, here we demonstrated an available method to differentiate rat iPSCs and ESCs into GC-like cells in vitro for the possible cell therapy of POF.

Co-author:Fang X*, Huang X, Liu F, Tan X, Wu Z, Li H, Zhang J1

Indexed by:Unit Twenty Basic Research

Discipline:临床医学

Document Type:J

Volume:45

Issue:4

Page Number:289-95

ISSN No.:():

Translation or Not:no

Date of Publication:2013-04-26

Links to published journals:http://www.ncbi.nlm.nih.gov/pubmed/?term=Differentiation+of+rat+iPS+cells+and+ES+cells+into+granulosa+cell-like+cells+in+vitro