黄皓，生物学博士，副研究员，硕士生导师，中南大学湘雅医院肾病内科博士后，美国康涅狄格大学医学中心联合培养博士。现担任中南大学生命科学学院十一党支部书记、生物标本馆主任。入选湖南省自然科学青年科学基金项目（B类）（原湖南省优秀青年科学基金项目）。主要从事器官纤维化尤其是肾脏纤维化的遗传机制及新药创制等研究。参与多项国家自然科学基金面上项目、国家科技重大专项子课题等项目研究工作。主持国家自然科学基金青年项目，中国博士后基金会特别资助站前项目、面上项目，湖南省自然科学基金面上项目、青年项目，中南大学湘雅医院青年基金等科研项目。近年在Circulation、Adv Sci、MedComm、Trends Endocrinol Metab、Transl Neurodegener、Sci China Life Sci、Int J Biol Sci、Free Radic Biol Med等发表第一或通讯论文23篇；授权国家发明专利2项；曾获湖南医学科技奖一等奖等。

在教学工作上，目前主持省级教改课题1项（重点课题）、校级教改课题2项，入选湖南省高校思想政治工作优秀案例，获中南大学教学质量优秀奖1次。指导多项国家级、省级大学生创新训练项目及研究生自由探索项目，指导学生获中南大学基础医学创新论坛一等奖、中南大学虚拟仿真设计大赛一等奖及中南大学志愿服务项目大赛金奖等。目前任教细胞生物学、细胞生物学实验、生物学进展等多门本科课程。

[1]     Li A, Huang H, Xiang R. Glucocorticoids mediate fasting efficacy in breast cancer. Trends Endocrinol Metab. 2026 May;37(5):395-397. doi: 10.1016/j.tem.2026.02.001. Epub 2026 Mar 11. PubMed PMID: 41820091.

[2]     Cheng J, Han Y, Zhang Y, He X, Zou S, She W, Peng Z, Huang L, Huang H. Lipidomic profiling reveals medium-chain acylcarnitines alterations as metabolic signatures in IgA nephropathy. BMC Nephrol. 2026 Feb 17;27(1). doi: 10.1186/s12882-026-04822-3. PubMed PMID: 41703479; PubMed Central PMCID: PMC13014795.

[3]     Feng W, Xie Z, Huang H. Direct peroxisome-mitochondria contact modulates ROS under stress. Sci China Life Sci. 2026 Jul;69(7):2530-2533. doi: 10.1007/s11427-025-3172-0. Epub 2026 Feb 13. PubMed PMID: 41706267.

[4]     Zhang Y, Huang H, Li N, Dong Y, Zhao M, Zhang S, She W, Liu J, Xiang R. Reticulon 3 deficiency induces ferroptosis via chaperone-mediated autophagy in ischemia-reperfusion induced acute kidney injury. Free Radic Biol Med. 2026 Jan;242:9-20. doi: 10.1016/j.freeradbiomed.2025.10.256. Epub 2025 Oct 10. PubMed PMID: 41077100.

[5]     Liu YX, Wang Q, Xiangyang ZY, Long JY, Huang H, Fan LL. Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury. Mol Biomed. 2025 Oct 10;6(1):78. doi: 10.1186/s43556-025-00317-z. PubMed PMID: 41071519; PubMed Central PMCID: PMC12514125.

[6]     Liu YX, Huang H, Wang F, Zhao MF, Jin JY, Dong Y, Wang Q, Fan LL, Xiang R. Lipin3 deficiency aggravates cisplatin induced acute kidney injury via activating Sirt1-p21-Caspase 3-GSDME pyroptosis pathway. Int J Biol Sci. 2025;21(12):5185-5205. doi: 10.7150/ijbs.110125. eCollection 2025. PubMed PMID: 40959286; PubMed Central PMCID: PMC12435314.

[7]     Wang CY, Chen YQ, Huang H, Yuan ZZ, Dong Y, Jin JY, Long JY, Liu L, Fan LL, Xiang R. RTN3 regulates collagen biosynthesis and profibrotic macrophage differentiation to promote pulmonary fibrosis via interacting with CRTH2. Mol Med. 2025 Feb 19;31(1):63. doi: 10.1186/s10020-025-01119-3. PubMed PMID: 39972424; PubMed Central PMCID: PMC11837708.

[8]     Huang H, Han Y, Zhang Y, Zeng J, He X, Cheng J, Wang S, Xiong Y, Yin H, Yuan Q, Huang L, Xie Y, Meng J, Tao L, Peng Z. Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis. Adv Sci (Weinh). 2025 Apr;12(13):e2408753. doi: 10.1002/advs.202408753. Epub 2025 Jan 21. PubMed PMID: 39836535; PubMed Central PMCID: PMC11967762.

[9]     Huang H, Xiang R, Yan R. Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer's disease. Transl Neurodegener. 2024 Jul 30;13(1):38. doi: 10.1186/s40035-024-00433-w. PubMed PMID: 39080732; PubMed Central PMCID: PMC11290272.

[10]  Guo S, Dong Y, Du R, Liu YX, Liu S, Wang Q, Liu JS, Xu H, Jiang YJ, Hao H, Fan LL, Xiang R. Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis. Mol Biomed. 2024 Jun 28;5(1):24. doi: 10.1186/s43556-024-00187-x. PubMed PMID: 38937317; PubMed Central PMCID: PMC11211315.

[11]  Hu Y, Huang H, Xiang R. GCGR: novel potential therapeutic target for chronic kidney disease. Sci China Life Sci. 2024 Jul;67(7):1542-1544. doi: 10.1007/s11427-024-2576-x. Epub 2024 Apr 26. PubMed PMID: 38679668.

[12]  Yuan Z, Wang Q, Wang C, Liu Y, Fan L, Liu Y, Huang H. Identification of a de novo CACNA1B variant and a start-loss ADRA2B variant in paroxysmal kinesigenic dyskinesia. Heliyon. 2024 Apr 15;10(7):e28674. doi: 10.1016/j.heliyon.2024.e28674. eCollection 2024 Apr 15. PubMed PMID: 38571653; PubMed Central PMCID: PMC10988053.

[13]  Wang Q, Liu Y, Zhang Y, Zhang S, Zhao M, Peng Z, Xu H, Huang H. Characterization of macrophages in ischemia-reperfusion injury-induced acute kidney injury based on single-cell RNA-Seq and bulk RNA-Seq analysis. Int Immunopharmacol. 2024 Mar 30;130:111754. doi: 10.1016/j.intimp.2024.111754. Epub 2024 Mar 1. PubMed PMID: 38428147.

[14]  Huang H, Sharoar MG, Pathoulas J, Fan L, He W, Xiang R, Yan R. Accumulation of neutral lipids in dystrophic neurites surrounding amyloid plaques in Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167086. doi: 10.1016/j.bbadis.2024.167086. Epub 2024 Feb 18. PubMed PMID: 38378084; PubMed Central PMCID: PMC10999334.

[15]  Du R, Liu JS, Huang H, Liu YX, Jin JY, Wang CY, Dong Y, Fan LL, Xiang R. RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability. Mitochondrion. 2024 Mar;75:101851. doi: 10.1016/j.mito.2024.101851. Epub 2024 Feb 7. PubMed PMID: 38336146.

[16]  Jin JY, Chang SH, Chen YQ, Liu MW, Dong Y, Liu JS, Wang Q, Huang H, Fan LL, Xiang R. Reticulon 3 regulates sphingosine-1-phosphate synthesis in endothelial cells to control blood pressure. MedComm (2020). 2024 Feb;5(2):e480. doi: 10.1002/mco2.480. eCollection 2024 Feb. PubMed PMID: 38352050; PubMed Central PMCID: PMC10863919.

[17]  Wang F, Liu Y, Dong Y, Zhao M, Huang H, Jin J, Fan L, Xiang R. Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1. Front Med. 2024 Feb;18(1):180-191. doi: 10.1007/s11684-023-1003-0. Epub 2023 Sep 30. PubMed PMID: 37776435.

[18]  Huang H, Yang X, Tao L, Xiang R, Yang H. Identification of a de novo heterozygous mutation of ANKZF1 in a Chinese patient with inflammatory bowel disease. QJM. 2023 Jun 8;116(6):463-465. doi: 10.1093/qjmed/hcad030. PubMed PMID: 36857589.

[19]  Gu L, He X, Zhang Y, Li S, Tang J, Ma R, Yang X, Huang H, Peng Y, Xie Y, Peng Z, Meng J, Hu G, Tao L, Liu X, Yang H. Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway. Biomed Pharmacother. 2023 Aug;164:114844. doi: 10.1016/j.biopha.2023.114844. Epub 2023 May 22. PubMed PMID: 37224750.

[20]  Huang H, Jin J, Xiang R, Wang X. Case report: A novel heterozygous frameshift mutation of ACAN in a Chinese family with short stature and advanced bone age. Front Genet. 2023;14:1101695. doi: 10.3389/fgene.2023.1101695. eCollection 2023. PubMed PMID: 37025453; PubMed Central PMCID: PMC10070732.

[21]  Huang H, Guo S, Chen YQ, Liu YX, Jin JY, Liang Y, Fan LL, Xiang R. Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK-IDH2 pathway. MedComm (2020). 2023 Apr;4(2):e226. doi: 10.1002/mco2.226. eCollection 2023 Apr. PubMed PMID: 36925557; PubMed Central PMCID: PMC10013133.

[22]  Zeng J, Huang H, Zhang Y, Lv X, Cheng J, Zou SJ, Han Y, Wang S, Gong L, Peng Z. Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage. Front Pharmacol. 2023;14:1095487. doi: 10.3389/fphar.2023.1095487. eCollection 2023. PubMed PMID: 36959860; PubMed Central PMCID: PMC10028454.

[23]  Li K, Zhu Y, Cheng J, Li A, Liu Y, Yang X, Huang H, Peng Z, Xu H. A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysis. Front Cell Dev Biol. 2023;11:1078759. doi: 10.3389/fcell.2023.1078759. eCollection 2023. PubMed PMID: 36866272; PubMed Central PMCID: PMC9971983.

[24]  Qiao X, Wu L, Tang J, Xiang R, Fan L, Huang H, Chen Y. Case report: A de novo Non-sense SOX9 mutation (p.Q417*) located in transactivation domain is Responsible for Campomelic Dysplasia. Front Pediatr. 2022;10:1089194. doi: 10.3389/fped.2022.1089194. eCollection 2022. PubMed PMID: 36741086; PubMed Central PMCID: PMC9890166.

[25]  Du R, Liu J, Hu Y, Peng S, Fan L, Xiang R, Huang H. Novel heterozygous mutation in COL4A4 responsible for Alport syndrome in a Chinese family. Front Genet. 2022;13:899006. doi: 10.3389/fgene.2022.899006. eCollection 2022. PubMed PMID: 36159970; PubMed Central PMCID: PMC9501878.

[26]  Huang C, Liang Y, Dong Y, Huang L, Li A, Du R, Huang H. Novel prognostic matrisome-related gene signature of head and neck squamous cell carcinoma. Front Cell Dev Biol. 2022;10:884590. doi: 10.3389/fcell.2022.884590. eCollection 2022. PubMed PMID: 36081907; PubMed Central PMCID: PMC9445128.

[27]  Huang H, Jin J, Wu L, Wu H, Pi H, Dong Y, Xiang R. A de novo Non-sense Nuclear Factor I B Mutation (p.Tyr290*) Is Responsible for Brain Malformation and Lung Lobulation Defects. Front Pediatr. 2022;10:865181. doi: 10.3389/fped.2022.865181. eCollection 2022. PubMed PMID: 35433561; PubMed Central PMCID: PMC9005976.

[28]  Huang C, He J, Dong Y, Huang L, Chen Y, Peng A, Huang H. Identification of Novel Prognostic Markers Associated With Laryngeal Squamous Cell Carcinoma Using Comprehensive Analysis. Front Oncol. 2021;11:779153. doi: 10.3389/fonc.2021.779153. eCollection 2021. PubMed PMID: 35087752; PubMed Central PMCID: PMC8787159.

[29]  Huang H, Chen Y, Jin J, Du R, Tang K, Fan L, Xiang R. CSRP3, p.Arg122*, is responsible for hypertrophic cardiomyopathy in a Chinese family. J Gene Med. 2022 Jan;24(1):e3390. doi: 10.1002/jgm.3390. Epub 2021 Oct 15. PubMed PMID: 34558151.

[30]  Huang H, Zhu L, Huang C, Dong Y, Fan L, Tao L, Peng Z, Xiang R. Identification of Hub Genes Associated With Clear Cell Renal Cell Carcinoma by Integrated Bioinformatics Analysis. Front Oncol. 2021;11:726655. doi: 10.3389/fonc.2021.726655. eCollection 2021. PubMed PMID: 34660292; PubMed Central PMCID: PMC8516333.

[31]  Dong Y, Du R, Fan LL, Jin JY, Huang H, Chen YQ, Bi DD, Xiang R. Whole-Exome Sequencing Identifies a Novel TRPM4 Mutation in a Chinese Family with Atrioventricular Block. Biomed Res Int. 2021;2021:9247541. doi: 10.1155/2021/9247541. eCollection 2021. PubMed PMID: 33959666; PubMed Central PMCID: PMC8075657.

[32]  Liu JS, Huang H, Jin JY, Du R, Wang CY, Fan LL. Identification of a Novel Arginine Vasopressin Receptor 2 Mutation (p.V183M) in a Chinese Family with Nephrogenic Diabetes Insipidus. Mol Syndromol. 2020 Jul;11(3):130-134. doi: 10.1159/000507035. Epub 2020 Mar 28. PubMed PMID: 32903920; PubMed Central PMCID: PMC7445547.

[33]  Jin JY, Zeng L, Li K, He JQ, Pang X, Huang H, Xiang R, Tang JY. A novel mutation (c.1010G>T; p.R337L) in TP63 as a cause of split-hand/foot malformation with hypodontia. J Gene Med. 2019 Oct;21(10):e3122. doi: 10.1002/jgm.3122. Epub 2019 Aug 30. PubMed PMID: 31420900.

[34]  Liu Y, He H, Fan L, Yuan J, Huang H, Yang W, Wang L, Mo Z, Wang F. Compound C attenuates NLRP3 inflammasome despite AMPK knockdown in LPS plus palmitate-induced THP-1 cells. Naunyn Schmiedebergs Arch Pharmacol. 2020 Jan;393(1):67-76. doi: 10.1007/s00210-019-01712-4. Epub 2019 Aug 16. PubMed PMID: 31420721.

[35]  Fan LL, Ding DB, Huang H, Chen YQ, Jin JY, Xia K, Xiang R. A de novo mutation of SMYD1 (p.F272L) is responsible for hypertrophic cardiomyopathy in a Chinese patient. Clin Chem Lab Med. 2019 Mar 26;57(4):532-539. doi: 10.1515/cclm-2018-0578. PubMed PMID: 30205637.

[36]  Fan LL, Liu JS, Huang H, Du R, Xiang R. Whole exome sequencing identified a novel mutation (p.Ala1884Pro) of β-spectrin in a Chinese family with hereditary spherocytosis. J Gene Med. 2019 Feb;21(2-3):e3073. doi: 10.1002/jgm.3073. Epub 2019 Feb 11. PubMed PMID: 30690801.

[37]  Fan LL, Chen YQ, Huang H, Yuan ZZ, Jin JY, Hu M, Xiang R. Exome sequencing identifies a novel nonsense mutation of Ring Finger Protein 207 in a Chinese family with Long QT syndrome and syncope. J Hum Genet. 2019 Mar;64(3):233-238. doi: 10.1038/s10038-018-0549-1. Epub 2018 Dec 12. PubMed PMID: 30542207.

[38]  Xiang R, Fan LL, Huang H, Chen YQ, He W, Guo S, Li JJ, Jin JY, Du R, Yan R, Xia K. Increased Reticulon 3 (RTN3) Leads to Obesity and Hypertriglyceridemia by Interacting With Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5). Circulation. 2018 Oct 23;138(17):1828-1838. doi: 10.1161/CIRCULATIONAHA.117.030718. PubMed PMID: 29716941; PubMed Central PMCID: PMC6392466.

[39]  Zhang SB, Liu YX, Fan LL, Huang H, Li JJ, Jin JY, Xiang R. A novel heterozygous variant p.(Trp538Arg) of SYNM is identified by whole-exome sequencing in a Chinese family with dilated cardiomyopathy. Ann Hum Genet. 2019 Mar;83(2):95-99. doi: 10.1111/ahg.12287. Epub 2018 Oct 2. PubMed PMID: 30276801.

[40]  Fan LL, Chen YQ, Huang H, Jin JY, Li JJ, Tan ZP. Whole-exome sequencing reveals doubly novel heterozygous Myosin Binding Protein C and Titin mutations in a Chinese patient with severe dilated cardiomyopathy. Cardiol Young. 2018 Dec;28(12):1410-1414. doi: 10.1017/S1047951118001403. Epub 2018 Aug 15. PubMed PMID: 30109841.

[41]  Huang H, Ding DB, Fan LL, Jin JY, Li JJ, Guo S, Chen YQ, Xiang R. Whole-exome sequencing identifies a Novel SCN5A mutation (C335R) in a Chinese family with arrhythmia. Cardiol Young. 2018 May;28(5):688-691. doi: 10.1017/S1047951117002980. Epub 2018 Feb 6. PubMed PMID: 29402340.

[42]  Fan LL, Huang H, Jin JY, Li JJ, Chen YQ, Zhao SP, Xiang R. Whole exome sequencing identifies a novel mutation (c.333 + 2T > C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease. Gene. 2018 Mar 30;648:63-67. doi: 10.1016/j.gene.2018.01.055. Epub 2018 Jan 20. PubMed PMID: 29355681.

[43]  Jin JY, Wu PF, Fan LL, Yu F, Li JJ, Fan XF, Huang H, Zeng L, Tang JY, Xiang R. A mutation of beta-tropomyosin gene in a Chinese family with distal arthrogryposis type I. Int J Clin Exp Pathol. 2017;10(11):11137-11142. eCollection 2017. PubMed PMID: 31966463; PubMed Central PMCID: PMC6965825.

[44]  Huang H, Chen YQ, Fan LL, Guo S, Li JJ, Jin JY, Xiang R. Whole-exome sequencing identifies a novel mutation of GPD1L (R189X) associated with familial conduction disease and sudden death. J Cell Mol Med. 2018 Feb;22(2):1350-1354. doi: 10.1111/jcmm.13409. Epub 2017 Oct 27. PubMed PMID: 29077258; PubMed Central PMCID: PMC5783853.

[45]  Wu PF, Jin JY, Li JJ, He JQ, Fan LL, Jin M, Huang H, Xia K, Tang JY, Xiang R. A novel splice-site mutation of WRN (c.IVS28+2T>C) identified in a consanguineous family with Werner Syndrome. Mol Med Rep. 2017 Jun;15(6):3735-3738. doi: 10.3892/mmr.2017.6465. Epub 2017 Apr 12. PubMed PMID: 28440507.

[46]  Du R, Fan LL, Lin MJ, He ZJ, Huang H, Chen YQ, Li JJ, Xia K, Zhao SP, Xiang R. Mutation detection in Chinese patients with familial hypercholesterolemia. Springerplus. 2016;5(1):2095. doi: 10.1186/s40064-016-3763-3. eCollection 2016. PubMed PMID: 28028493; PubMed Central PMCID: PMC5153400.

[47]  Xiang R, Fan LL, Huang H, Zhao SP, Chen YQ. Whole-exome sequencing identifies a novel mutation of DSG2 (Y198C) in a Chinese arrhythmogenic right ventricular cardiomyopathy patient. Int J Cardiol. 2016 Jul 1;214:1-3. doi: 10.1016/j.ijcard.2016.03.136. Epub 2016 Mar 26. PubMed PMID: 27055156.

[48]  Du RF, Huang H, Fan LL, Li XP, Xia K, Xiang R. A Novel Mutation of FOXC1 (R127L) in an Axenfeld-Rieger Syndrome Family with Glaucoma and Multiple Congenital Heart Diseases. Ophthalmic Genet. 2016;37(1):111-5. doi: 10.3109/13816810.2014.924016. Epub 2014 Jun 10. PubMed PMID: 24914578.

1. 国家自然科学基金，青年项目，82300787，LPIN3通过GPX4调控近端肾小管上皮细胞铁死亡在急性肾损伤中的机制研究，2024-01至2026-12，30万元，在研，主持；

2. 湖南省科技厅，湖南省自然科学基金青年科学基金项目（B类），2026JJ40081，RTN2介导的FSP1-m6A去甲基化修饰调控肾小管上皮细胞铁死亡在急性肾损伤中的机制研究，2026-01至2028-12，20万元，在研，主持；

3. 湖南省科技厅，湖南省自然科学基金面上项目，2025JJ50519，丙酮酸羧化酶通过cGAS/STING调控肾小管上皮细胞代谢重编程在肾脏纤维化中的机制研究，2025-01至2027-12，5万元，在研，主持；

4. 中国博士后基金会，特别资助（站前）项目，2020TQ0363，氟非尼酮通过RTN3-IGF2-JAK2调控胶原合成在肾损伤修复中的作用，2020-08至2023-08，18万元，已结题，主持；

5. 中国博士后基金会，面上资助项目，2020M682598，ABCA8调控脂代谢异常在肾小球硬化症中的机制探究，2020-11至2022-11，8万元，已结题，主持；

6. 湖南省科技厅，湖南省自然科学基金青年项目，2021JJ40992，ABCA8调控巨噬细胞泡沫化在慢性肾病中的作用机制研究，2021-01至2023-12，5万元，已结题，主持；

7. 湖南省科技厅，湖南省创新型省份建设科普项目，2023ZK4046，“科普影漫途”：热点科幻影视与动漫作品的科普解读，2024-01至2024-12，5万元，资助期满，主持；

8. 中南大学湘雅医院，青年科研基金项目，2021Q11，利用多组学技术探索氟非尼酮通过丙酮酸羧化酶调控线粒体能量代谢发挥抗肾脏纤维化的作用及机制，2022-01至2024-12，10万元，已结题，主持。

1. 项荣，金介员，黄皓，范亮亮. 肥厚性心肌病致病基因及其应用，2021-08-06，中国，ZL202010680968.9.

2. 项荣，罗穆峰，黄皓，范亮亮. 一种可应用于传染病病原体测序的读段映射延伸方法，2022-09-23，中国，ZL202011597128.2.

1. 湖南省普通本科高校教学改革研究项目，重点项目，202502000164，虚拟生物标本馆的构建及其在拔尖创新人才培养中的应用，2025-01至2026-12，2万元，在研，主持；

2. 中南大学教育教学改革研究项目，2025jy039，虚拟生物标本馆的构建，2025-01至2026-12，0.5万元，在研，主持；

3. 2025年度湖南省高校思想政治工作优秀案例，2025AL006，标本无言，育人有道：中南大学生物标本馆赋能拔尖创新人才培养的探索与成效，主持；

4. 中南大学2023-2024学年教学质量优秀奖（创新创业教育）创客空间优秀指导老师。