Name: Guangdi Li

Position: Professor, Doctoral and Master Supervisor in the Xiangya School of Public Health, Central South University

Degree: PhD in Biomedicine, MS in Computer Science, BA in Mathematics

Email: liguangdi@csu.edu.cn, 550604042@qq.com

Tel: 0731-84805414

Research focus: 

Our team focuses on the viral epidemiology and genomics based on interdisciplinary approaches of Computer Science, Biochemistry, Biomedicine, and Preventive Healthcare. With collaborations with doctors and nurses, our team is committed to the development of viral databases and bioinformatics algorithms to solve clinical problems in the management of infectious diseases.

Based on extensive scientific and teaching work, I was awarded as the "Outstanding Youth" of Hunan Province, the "Huxiang Young Talent" of Hunan Province, the "Returning Overseas Chinese" of Hunan Province, and the "50 Outstanding Party Members" of Hunan Province.

(1). Education background

2009/09 — 2014/08, University of Leuven, Belgium (45th in Times Global University Rankings 2024), School of Medicine, PhD in Biomedicine

2010/09 - 2011/07, KU Leuven, Belgium, School of Life Sciences, Master of Chemistry and Biophysics

2008/03 — 2009/08, Universidad Politécnica de Madrid (UPM in Spain), School of Computer Science

2006/09 — 2009/06, Shandong University, School of Computer Science and Technology, Master of Computer Software and Theory

2002/09 — 2006/06, Hunan University, School of Mathematics and Econometrics, Bachelor of Mathematics and Applied Mathematics

1996/09 — 2002/06, Middle School and High School Affiliated to Hunan Normal University

(2). Work experience

2023/10 — Present, Full Professor, doctoral supervisor, master supervisor, Xiangya School of Public Health, Central South University

2018/04 — 2023/09, Associate Professor, doctoral supervisor, master supervisor, Xiangya School of Public Health, Central South University

2015/01 — 2018/02, Research Fellow, master supervisor, Second Xiangya Hospital of Central South University

2009/09 — 2014/08, Research Assistant, School of Medicine, University of Leuven, Belgium

2008/03 — 2009/08, Research Assistant, School of Computer Science, UPM, Polytechnic University of Madrid, Spain

(3). Awards

2024, "Outstanding Youth" of Hunan Province

2024, "Excellence Award of graduate Teaching" in Central South University

2023, the 18th "Challenge Cup" National College Student Extracurricular Academic Science and Technology Competition in China, the Second prize in China, the first mentor

2023, "Excellent Class Tutor" in Central South University

2023, 50 Outstanding Returned Party Members in Hunan Province (Hunan Provincial Committee of Zhi Gong Party)

2022, "Outstanding Undergraduate Thesis Instructor" in Central South University

2020, "Excellent Individuals" in the fight against the coronavirus epidemic (Hunan Provincial Committee of the Zhi Gong Party)

2018, "Huxiang Young Talents" of Hunan Province

2017, Special Award of Scientific Research Achievement in Central South University

2008, The 5th Postgraduate Mathematical Modeling Competition in China, the first prize in China

(4). Research grants

I am the principal investigator of 9 research grants, including 4 national grants, 3 provincial grants, and 2 university grants.

1. Principal Investigator, Molecular Epidemiology and Bioinformatics Research on Human Viruses, Hunan Province Outstanding Youth Project (Grant No.: 2024JJ2069), 2024/05 - 2027/05

2. Principal Investigator, Bioinformatics research on COVID-19 protein-host immune protein dynamic regulatory networks and its broad-spectrum drug targets, National Natural Science Foundation of China - Major Research Plan (Grant No.: 92269112), 2023/01 - 2025/12

3. Principal Investigator, Bioinformatics study of drug resistance induced by whole-genome coevolution of HIV, National Natural Science Foundation of China (Grant No.: 31871324), 2019/01–2022/12

4. Principal Investigator, Investigation of HIV-1 whole-genome Protein Interactions Based on Systems Biology, National Natural Science Foundation of China - General Project (Grant No.: 31571368), 2016/01–2019/12

5. Co-Principal Investigator. The mechanism of persistent HCV infection escaping the innate immune response of human liver cells, the National Natural Science Foundation of China (Grant No.: 81730064), 2018/01–2022/12

6. Principal Investigator, Systems Biology Research on HIV Gag Gene Mutation-Induced Protease Inhibitor Resistance, Hunan Provincial Natural Science Foundation - Youth Project (Grant No.: 2018JJ3713), 2018/01–2020/12

7. Principal Investigator, Huxiang Young Talents in Hunan Province (Grant No.: 2018RS3006), 2019/01–2021/12

8. Principal Investigator, Talent Program in Central South University, 2019/01–2021/12

9. Principal Investigator,“Innovation Driven Plan” Talent Program in Central South University (Grant No.: 2016CX031), 2016/01–2017/12

(5). Education and Teaching Grants

1. Principal Investigator, Online Statistical Software + Offline Case Teaching for Undergraduates in the Course Construction and Practice of "Medical Statistics", Hunan Province Undergraduate Teaching Project, (Grant No.: 202401000353), 2024/03 - 2026/03

2. Principal Investigator, The Construction of "online and offline" dual-track teaching for graduate students in "Medical Statistics", Central South University Graduate School (Grant No.: 2024ALK019), 2024/05 - 2026/05

3. Principal Investigator, Ideological and Political Construction of the "Medical Statistics" Course for International Students, Central South University Graduate School, 2023/05 - 2025/05

(6). Research publications

In the field of viral epidemiology and viral bioinformatics, our team published more than 60 SCI papers, including >30 papers by the first or corresponding author (total impact factor >400, citations >7000 times).

1. Guangdi Li*, Rolf Hilgenfeld*, Richard Whitley*, Erik De Clercq*, Therapeutic strategies for COVID-19: progress and lessons learned, Nature Reviews Drug Discovery, 2023 Jun;22(6):449-475 (第一作者/共同通讯作者，影响因子：122.7，Nature子刊封面论文，ESI千分之一高被引论文)

2. Yujin Ding, Pan Zhang, Tuo Deng, Xiang Yan, Min Zhang, Zhiguo Xie, Gan Huang, Ping Wang, Ting Cai, Xiaoli Zhang, Xinqiang Xiao, Ying Xia, Bingwen Liu, Ya Peng, Xiaohan Tang, Ming Hu, Yang Xiao, Xia Li, Erik De Clercq, Guangdi Li*, Zhiguang Zhou*, Association of HLA footprints with the comorbidity of latent autoimmune diabetes in adults (LADA) and HCV infection: A Multicenter Cross-Sectional Study, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2024 January; 18(1):102939 (共同通讯作者，影响因子：10.1)

3. Pan Zhang, Xiaowen Hu, Guangdi Li*, Lei Deng*, AntiViralDL: Computational Antiviral Drug Repurposing Using Graph Neural Network and Self-Supervised Learning, IEEE Journal of Biomedical and Health Informatics, 2024, 28(1):548-556 (共同通讯作者，影响因子：7.7，JCR一区)

4. Erik De Clercq#, Guangdi Li#, Yun Zhang#, Jie Huang, Li Tan*, Unachieved antiviral strategies with acyclic nucleoside phosphonates: Dedicated to the memory of dr. Salvatore "Sam" Joseph Enna, Biochemical Pharmacology,  2024 Jul 21:116448 (共同第一作者，影响因子：5.3，JCR一区)

5. Erik De Clercq#, Zhenlan Zhang#, Jie Huang, Min Zhang*, Guangdi Li*, Biktarvy for the treatment of HIV infection: Progress and prospects, Biochemical Pharmacology. 2023 Nov:217:115862 (最后通讯作者，影响因子：5.3，JCR一区)

6. Ting Cai, Tingting Yue, Ming Xu, Pan Zhang, Yue Wang, Qi Liu, Jie Huang, Ting Shen, Qiang Yin, Zhifeng Sheng, Yang Xiao, Tuo Deng, Min Zhang, Erik De Clercq, Chi Zhang*, Guangdi Li*, Poor glycemic control in type-2 diabetic patients infected with hepatitis B: a retrospective propensity-matched study, Journal of Medical Virology, 2023, Mar;95(3):e28635 (最后通讯作者，影响因子：6.8，JCR一区)

7. Ming Xu, Ting Cai, Tingting Yue, Pan Zhang, Jie Huang, Qi Liu, Yue Wang, Ruping Luo, Zhengqiu Li, Linli Luo, Chunyi Ji, Xinrui Tan, Yanling Zheng, Richard Whitley, Erik De Clercq, Qiang Yin*, Guangdi Li*, Comparative Effectiveness of Oseltamivir versus Peramivir for Hospitalized Children (ages 0–5 years) with Influenza Infection, International Journal of Infectious Diseases, 2023 Mar;128:157-165 (最后通讯作者，影响因子：8.4，JCR一区)

8. Chen Jia#, Zhiguo Zhou#, Song Li#, Pan Zhang#, Wenjing Pan, Ming Yang, Mingming Zhao, Bo Li, Ping Liu, Qianqian Zhang, Xianglong Kong, Keyu Li, Zijun Wang, Tingting Yue, Ting Cai, Erik De Clercq,  Song Li*, Guangdi Li*, Jiyang Liu*, Haijing Wu*, Qianjin Lu*，Immune Repertoire Sequencing Reveals an Abnormal Adaptive Immune System in COVID-19 Survivors，Journal of Medical Virology, 2023 Jan;95(1):e28340 (共同通讯作者，影响因子：12.7，JCR一区)

9. Erik De Clercq, Yike Jiang, Guangdi Li*, Therapeutic strategies for human poxvirus infections: monkeypox (mpox), smallpox, molluscipox, and orf,Travel Medicine and Infectious Disease, 2022，52:102528（唯一通讯作者，影响因子：12.0，JCR一区）

10. Guangdi Li, Yali Wang*, Erik De Clercq*, Approved HIV reverse transcriptase inhibitors in the past decade, Acta Pharmaceutica Sinica B, 2022 Apr;12(4):1567-1590 (第一作者，影响因子：14.5，JCR一区)

11. Guangdi Li, Erik De Clercq*, A medicinal chemist who reshaped the antiviral drug industry , Medicinal Research Reviews,2022 Mar;42(2):647-653(第一作者，影响因子：13.3，JCR一区)

12. Tingting Yue, Quanquan Zhang, Ting Cai, Ming Xu, Haizhen Zhu, Mahmoud Reza Pourkarim, Erik De Clercq, Guangdi Li*,Trends in the disease burden of HBV and HCV infection in China from 1990-2019, International journal of infectious diseases, 2022 Jun 17;122:476-485. (唯一通讯作者，影响因子：8.4，JCR一区)

13. Xixi Jing #, Min Xu #, Deye Song#, Tingting Yue, Yali Wang, Pan Zhang, Yanjun Zhong, Min Zhang, Tommy Tsan-Yuk Lam, Nuno Rodrigues Faria, Erik De Clercq Guangdi Li*, Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19, Immunity & Ageing, 2022 Mar 5;19(1):12（唯一通讯作者，JCR一区，影响因子: 7.9，JCR一区）

14. Tingting Yue, Ming Xu, Ting Cai, Haizhen Zhu, Mahmoud Reza Pourkarim, Erik De Clercq, Guangdi Li*， Gender disparity and temporal trend of liver cancer in China from 1990 to 2019 and predictions in a 25-year period, Frontiers in Public Health，2022 Jun 9;10:902537 (唯一通讯作者，影响因子：5.2，JCR一区)

15. Tingting Yue, Pan Zhang, Yuantao Hao, Jianmei He, Jun Zheng, Erik De Clercq, Guangdi Li*, Yaxiong Huang*, Fang Zheng*, Epidemiology and Clinical Outcomes of HIV Infection in South-Central China: A Retrospective Study From 2003 to 2018, Frontiers in Public Health，2022 Jun 9;10:902537 (共同通讯作者，影响因子：5.2，JCR一区)

16. Tingting Yue#, Quanquan Zhang#, Guangdi Li*, Hong Qin*，Global Burden of Nutritional Deficiencies among Children under 5 Years of Age from 2010 to 2019，Nutrients. 2022 Jun 28;14(13):2685 (共同通讯作者，影响因子：5.9，JCR一区)

17. Miao Miao, Erik De Clercq, Guangdi Li*，Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches, Microorganisms, 2022, 10(9), 1785 (唯一通讯作者，影响因子：4.5，JCR二区)

18. Miao Miao, Erik De Clercq, Guangdi Li*.Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective, Biomedicines 2021, 9, 412 (唯一通讯作者，影响因子：6.05，JCR一区)

19. Guangdi Li, Ming Xu, Tingting Yue, Weijie Gu, and Li Tan*, Life-long Passion for Antiviral Research and Teaching: 80th Anniversary of Prof. Dr. Erik De Clercq, Biochemical Pharmacology, 2021 Feb 19;185:114485 (第一作者，影响因子：6.1，JCR一区)

20. Guangdi Li, Tingting Yue, Pan Zhang, Weijie Gu, Ling-Jie Gao, and Li Tan*, Drug Discovery of Nucleos(t)ide Antiviral Agents, Molecules, 2021 Feb 9;26(4):923 (第一作者，影响因子：4.927，JCR二区)

21. Guangdi Li*,Erik De Clercq*, Therapeutic options for the 2019 novel coronavirus (2019-nCoV), Nature Reviews Drug Discovery. 2020,March;19(3):149-150（第一作者，影响因子：84.69，引用次数>1000）

22. Chuanhao Jiang, Yali Wang, Min Hu, Lingjun Wen, Chuan Wen, Yang Wang, Weihong Zhu, Shi Tai, Zhongbiao Jiang, Kui Xiao, Nuno Rodrigues Faria, Erik De Clercq, Junmei Xu, Guangdi Li*. Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clinical & Translational Immunology.2020 Sep 26;9(9):e1182 (唯一通讯作者，影响因子：6.16)

23. Guangdi Li,Yacong Liu, Xixi Jing, Yali Wang, Miao Miao, Li Tao, Zhiguo Zhou, Yuanlin Xie, Yaxiong Huang, Jianhua Lei, Guozhong Gong, Ping Jin, Yuantao Hao, Nuno Rodrigues Faria, Erik De Clercq, Min Zhang*. Mortality risk of COVID-19 in elderly males with comorbidities: A multi-country study, Aging. 2020 Dec 31;13(1):27-60 (第一作者，影响因子：5.68，JCR一区)

24. Zhiguo Zhou†, Min Zhang†, Yali Wang†, Fang Zheng, Yaxiong Huang, Kang Huang, Qizhi Yu, Chunlin Cai, Dong Chen, Yi Tian, Jianhua Lei, Xinqiang Xiao, Erik De Clercq,Guangdi Li*,Yuanlin Xie*, Guozhong Gong*, Clinical characteristics of older and younger patients infected with SARS-CoV-2, Aging. 202012(12):11296-11305 (共同通讯作者，影响因子：5.68，JCR一区)

25. Miao Miao, Xixi Jing, Erik De Clercq,Guangdi Li*, Danoprevir for the Treatment of Hepatitis C Virus Infection, Drug Design, Development and Therapy, 2020 July:14: 2759-2774 (唯一通讯作者，影响因子：4.16，JCR二区)

26. Miao Miao, Erik De Clercq,Guangdi Li*, Clinical significance of chemokine receptor antagonists, Expert Opinion on Drug Metabolism & Toxicology, 2020 Jan;16(1):11-30（唯一通讯作者, 影响因子：4.48，JCR二区）

27. Min Zhang†,Guangdi Li†,Jia Shang, Chen Pan, Minxiang Zhang, Zhibiao Yin 6, Qing Xie, Yanzhong Peng, Qing Mao, Xinqiang Xiao, Yongfang Jiang1, Kaizhong Luo1, Yun Xu, Hai Ding, Wenzhou Fan, Vidaurre Diego, MahmoudReza Pourkarim, Erik De Clercq, Guiqiang Wang*, Guozhong Gong*,Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study, Hepatology International, 2020，14(2):212-2242020 (共同第一作者，影响因子:6.05)

28. Yali Wang, Erik De Clercq,Guangdi Li*, Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment,Expert Opinion on Drug Metabolism & Toxicology, 15(10):813-829, 2019（唯一通讯作者，影响因子：3.487，JCR二区）

29. Erik De Clercq,Guangdi Li*，Approved Antiviral Drugs over the Past 50 Years，Clinical Microbiology Reviews. Jul;29(3):695-747, 2016（共同通讯作者，影响因子：19.96， 被评为期刊封面论文，入选前0.1% ESI千分之一热点论文，JCR一区）、

30. Guangdi Li*, Erik De Clercq*, HIV Genome-Wide Protein Associations: a Review of 30 Years of Research, Microbiology and Molecular Biology Reviews. 80(3):679-731, 2016（第一作者，影响因子14.6，期刊封面，JCR一区）

31. Guangdi Li*, Erik De Clercq*, Current therapy for chronic hepatitis C: The role of direct-acting antivirals, Antiviral Research. 24;142:83-122, 2017（第一作者，影响因子：4.307，期刊封面论文，入选前1% ESI高频引用论文）

32. Guangdi Li, Kristof Theys, Jens Verheyen, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Supinya Piampongsant, Mónica Eusébio, Jan Ramon, Anne-Mieke Vandamme. A new ensemble coevolution system for detecting HIV-1 protein coevolution. Biology Direct, 10:1, 2015 (第一作者，影响因子: 4.04， JCR二区)

33. Guangdi Li, Supinya Piampongsant, Nuno Rodrigues Faria, Arnout Voet, Andrea-Clemencia Pineda-Peña, Ricardo Khouri, Philippe Lemey, Anne-Mieke Vandamme, Kristof Theys. An integrated map of HIV genome-wide diversity from a population perspective. Retrovirology, 12:18, 2015 (第一作者，影响因子: 3.99， JCR二区)

34. Guangdi Li, Jens Verheyen, Kristof Theys, Supinya Piampongsant, Kristel Van Laethem, Anne-Mieke Vandamme. HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes. Retrovirology, 11:79, 2014 (第一作者，影响因子: 4.19， JCR一区)

35. Guangdi Li, Jens Verheyen, Soo-Yon Rhee, Arnout Voet, Anne-Mieke Vandamme, Kristof Theys, Functional conservation of HIV-1 Gag: implications for rational drug design. Retrovirology 10(1):126. 2013 (第一作者，影响因子: 5.66)

36. Lize Cuypers†,Guangdi Li†, Christoph Neumann-Haefelin, Supinya Piampongsant, Pieter Libin, Kristel Van Laethem, Anne-Mieke Vandamme and Kristof Theys. Mapping the genomic diversity of HCV subtypes 1a and 1b: Implications of structural and immunological constraints for vaccine and drug development. Virus Evolution, 2(2): vew024, 2016 (共同第一，影响因子: 5.4， JCR一区)

37. Marijn Thijssen, Gholamreza Khamisipour, Mohammad Maleki, Timothy Devos, Guangdi Li, Marc Van Ranst, Jelle Matthijnssens, Mahmoud Reza Pourkarim，Characterization of the Human Blood Virome in Iranian Multiple Transfused Patients. Viruses . 2023 Jun 23;15(7):1425 （合作作者，JCR一区，影响因子：4.7）

38. Mengmeng Guo, Wenyan Cao, Shengwen Chen, Renyun Tian, Binbin Xue, Luoling Wang, Qian Liu, Rilin Deng, Xintao Wang, Zhenghao Wang, Yingdan Zhang, Di Yang, Chaohui Zuo, Guangdi Li, Songqing Tang, Haizhen Zhu, TRIM21 Regulates Virus-Induced Cell Pyroptosis through Polyubiquitination of ISG12a, Journal of Immunology. 2022 Nov 15;209(10):1987-1998 （合作作者，JCR一区，影响因子：5.426）

39. Haijing Wu, Yaxiong Deng, Di Long, Ming Yang, Qianwen Li, Yu Feng, Yongjian Chen, Hong Qiu, Xin Huang, Zhenghao He, Longyuan Hu, Heng Yin, Guangdi Li, Yunkai Guo, Wenhan Du, Ming Zhao, Liwei Lu, Qianjin Lu, The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease, Clinical And Translational Medicine. 2022 Mar;12(3):e781（合作作者，JCR一区，影响因子：8.554）

40. Xiaozhou Li#, Jian Pan#, Huiling Li, Guangdi Li, Bohao Liu, Xianming Tang, Xiangfeng Liu, Zhibiao He, Zhenyu Peng, Hongliang Zhang, Luxiang Wang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Dongshan Zhang*，DsbA-L interacts with VDAC1 in mitochondrion-mediated tubular cell apoptosis and contributes to the progression of acute kidney disease，EBioMedicine . 2022 Feb 3;76:103859（合作作者，JCR一区，影响因子：8.14）

41. Yujin Ding, Guangdi Li, Zhiguang Zhou, Tuo Deng, Molecular mechanisms underlying hepatitis C virus infection-related diabetes, Metabolism-Clinical and Experimental. 2021 Aug;121:154802（合作作者，JCR一区，影响因子：13.934）

42. William Marciel de Souza, Lewis Fletcher Buss, Darlan da Silva Candido, Jean-Paul Carrera, Sabrina Li, Alexander E. Zarebski, Rafael Henrique Moraes Pereira, Carlos A. Prete Jr, Andreza Aruska de Souza-Santos, Kris V. Parag, Maria Carolina T. D. Belotti, Maria F. Vincenti-Gonzalez, Janey Messina, Flavia Cristina da Silva Sales, Pamela dos Santos Andrade, Vítor Heloiz Nascimento, Fabio Ghilardi, Leandro Abade, Bernardo Gutierrez, Moritz U. G. Kraemer, Carlos K. V. Braga, Renato Santana Aguiar, Neal Alexander, Philippe Mayaud, Oliver J. Brady, Izabel Marcilio, Nelson Gouveia, Guangdi Li, Adriana Tami, Silvano Barbosa de Oliveira, Victor Bertollo Gomes Porto , Fabiana Ganem, Walquiria Aparecida Ferreira de Almeida, Francieli Fontana Sutile Tardetti Fantinato, Eduardo Marques Macário, Wanderson Kleber de Oliveira, Mauricio L. Nogueira, Oliver G. Pybus, Chieh-Hsi Wu, Julio Croda, Ester C. Sabino, and Nuno Rodrigues Faria. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil. Nature Human Behaviour. 2020 Aug;4(8):856-65. PMID: 32737472. doi: 10.1038/s41562-020-0928-4. (合作作者，影响因子：24.25， JCR一区)

43. Xiaozhou Li, Jian Pan, Huiling Li, Guangdi Li, Xiangfeng Liu, Bohao Liu, Zhibiao He, Zhengyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Xiangping Chai, Yunchang Yuan, Peilin Zheng, Feng Liu, Dongshan Zhang. DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice. Nature Communications. 2020 Sep 18;11(1):4467 (合作作者，影响因子：12.121， JCR一区)

44. Sai-Qun Luo, De-Hui Xiong, Jiang Li, Guangdi Li, Yali Wang, Jia-Ming Zhang, Xiu-Fen Bu, Wei-Xin Hu, Jingping Hu, C1orf35 contributes to tumorigenesis by activating c-MYC transcription in multiple myeloma. Oncogene. 2020 Apr;39(16):3354-66. (合作作者，影响因子：7.971， JCR一区)

45. Rilin Deng, Chaohui Zuo, Yongqi Li, Binbin Xue, Zhen Xun, Yanxia Guo, Xiaohong Wang, Yan Xu, Renyun Tian, Shengwen Chen, Qian Liu, Jinwen Chen, Jingjing Wang, Xiang Huang, Huiyi Li, Mengmeng Guo, Xintao Wang, Miaomiao Yang, Zhihui Wu, Jinfeng Wang, Jiahuan Ma, Jun Hu,Guangdi Li, Songqing Tang, Zhengkun Tu, Hongbin Ji, and Haizhen Zhu, The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 2020 Nov;17(11):1163-1179 (合作作者，影响因子：22.1， JCR一区)

46. Qian Li, Yifan Wang, Weijuan Jia, Heran Deng, Guangdi Li, Weiye Deng, Jiewen Chen, Betty Y S Kim, Wen Jiang, Qiang Liu, Jieqiong Liu, Low-Dose Anti-Angiogenic Therapy Sensitizes Breast Cancer to PD-1 Blockade. Clin Cancer Res. 2020 Apr 1;26(7):1712-24. (合作作者，影响因子：10.107， JCR一区)

47. Qinya Xie, Shengwen Chen, Renyun Tian, Xiang Huang, Rilin Deng, Binbin Xue, Yuwen Qin, Yan Xu, Jingjing Wang, Mengmeng Guo, Jinwen Chen, Songqing Tang, Guangdi Li, Haizhen Zhu, Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5, Journal of Virology, 2018 Aug 16;92(17). pii: e00507-18 (合作作者，影响因子：4.368，JCR一区)

48. Binbin Xue, Huiyi Li, Mengmeng Guo, Jingjing Wang, Yan Xu, Xuan Zou, Rilin Deng, Darong Yang, Guangdi Li, Haizhen Zhu. TRIM21 promotes innate immune response through Lys27-linked poly-ubiquitination of MAVS, Journal of Virology, 2018 Jun 29;92(14):e00321-18  (合作作者，影响因子：4.368， JCR一区)

49. Yuwen Qin, Binbin Xue, Chunyan liu, Xiaohong Wang, Renyun Tian, Qinya Xie, Mengmeng Guo, Guangdi Li, Darong Yang, and Haizhen Zhu.NLRX1 mediates MAVS degradation to attenuate hepatitis C virus-induced innate immune response through PCBP2.Journal of Virology, 91:23 e01264-17, 2017 (合作作者，影响因子：4.663，JCR一区)

50. Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7，JCR一区)

51. Linyun He, Mowei Tang, Ting Xiao, Hailan Liu, Wei Liu, Guangdi Li, Feng Zhang, Yalun Xiao, Zhiguang Zhou, Feng Liu1, Fang Hu. Obesity Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1α Transcriptional Network. Diabetes. 2018 Dec;67(12):2585-2600 (合作作者，影响因子：7.273， JCR一区)

52. Wen Meng, Xiuci Liang, Hongzhi Chen, Hairong Luo, Juli Bai, Guangdi Li, Qinghai Zhang, Ting Xiao, Sijia He, Yacheng Zhang, Zhipeng Xu, Bo Xiao, Fang Hu, and Feng Liu, Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway, Diabetes, 66(5):1196-1213, 2017 (合作作者，影响因子: 8.7，JCR一区)

53. Ahmed A Al-Qahtani, Mahmoud Reza Pourkarim, Nídia Sequeira Trovão, Valentijn Vergote, Guangdi Li, Marijn Thijssen, Ayman A Abdo, Faisal M Sanai, Damian Dela Cruz, Marie Fe F Bohol, Mashael R Al-Anazi, Mohammed N Al-Ahdal，Molecular epidemiology, phylogenetic analysis and genotype distribution of hepatitis B virus in Saudi Arabia: Predominance of genotype D1. Infect Genet Evol. 2020 Jan;77:104051. PMID: 31634640. doi: 10.1016/j.meegid.2019.104051 (合作作者，影响因子：2.773)

54. Andrea-Clemencia Pineda-Peña, Marta Pingarilho, Guangdi Li, Bram Vrancken, Pieter Libin, Perpétua Gomes, Ricardo Jorge Camacho, Kristof Theys, Ana Barroso Abecasis, Portuguese HIV-1 Resistance Study Group, Drivers of HIV-1 transmission: The Portuguese case. PLoS One. 2019;14(9):e0218226. (合作作者，影响因子：2.74)

55. Meizhu Liu, Lingxiang Wu, Weijing Wu, Guangdi Li, Taisheng Cai, Jiaxi Liu. The relationships among verbal ability, executive function, and theory of mind in young children with cochlear implants. International journal of audiology, 2018 Dec;57(12):875-882 (合作作者，影响因子：1.759， JCR高被引)

56. Li Tan, Le Bai, Ling Wang, Lagu He, Guangdi Li, Wenhan Du, Ting Shen, Zheyi Xiang, Jiali Wu, Zhonghua Liu, Min Hu. Antifungal activity of spider venom-derived peptide lycosin-I against Candida tropicalis. Microbiological Research. 2018 Nov;216:120-128. (合作作者，影响因子：2.777,JCR二区)

57. Zhuoying Liu, Ting Xiao, Guangdi Li, Fang Hu. APPL, More Than Just Adiponectin Receptor Binding Proteins. Cellular Signalling, 32:76-84, 2017 (合作作者，影响因子: 4.2,JCR一区)

58. Lize Cuypers, Francesca Ceccherini Silberstein, Kristel Van Laethem, Guangdi Li, Anne-Mieke Vandamme, Jürgen Kurt Rockstroh. Impact of HCV genotype on treatment regimens and drug resistance: a snapshot in time: HCV genotyping for treatment and drug resistance, Reviews in Medical Virology, Nov;26(6):408-434, 2016 (合作作者，影响因子: 4.5,JCR一区)

59. Steven Sijmons, Kim Thys, Mirabeau Mbong Ngwese, Ellen Van Damme, Jan Dvorak, Marnix Van Loock, Guangdi Li, Ruth Tachezy, Laurent Busson, Jeroen Aerssens, Marc Van Ranst and Piet Maes. High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination, Journal of Virology, 89(15):7673–7695, 2015 (合作作者，影响因子: 4.7)

60. Andrea-Clemencia Pineda, Nuno Rodrigues Faria, Francisco-Javier Diaz, Patricia Olaya, Casper Møller Frederiksen, Guangdi Li, Arley Gomez-Lopez, Philippe Lemey, Anne-Mieke Vandamme. Trends and Predictors of Transmitted Drug Resistance (TDR) and Clusters with TDR in a Local Belgian HIV-1 Epidemic. PLOS One, PLoS ONE 01; 9(7):e101738, 2014 (合作作者，影响因子: 3.51)

61. Sarah Megens, Dolores Vaira, Greet De Baets, Nathalie Dekeersmaeker, Yoeri Schrooten, Guangdi Li, Joost Schymkowitz, Frederic Rousseau, Anne-Mieke Vandamme, Michel Moutschen, Kristel Van Laethem. Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits, Virology, 456:310–318, 2014 (合作作者，影响因子: 3.27)

62. Eline Boons, Guangdi Li, Els Vanstreels, Thomas Vercruysse, Christophe Pannecouque, Anne-Mieke Vandamme, Dirk Daelemans. A stably expressed llama single-domain intrabody targeting Rev displays broad-spectrum anti-HIV activity. Antiviral Research, 12, 91-102, 2014 (合作作者，影响因子: 3.43)

(7). Books and Book Chapters

1. "Medical Statistics" Fifth Edition - Chapter 41 R Language, Publisher: People's Medical Publishing House, 2020

2. "Encyclopedia of Virology, Fourth Edition" - Volume 4-Chapter 1: Antiviral Classification, Publisher: Academic Press, 2021

3. "Antiviral Discovery for Highly Pathogenic Emerging viruses", Chapter 1: Overview of Antiviral Drug Discovery and Development, Publisher: The Royal Society of Chemistry, 2021

(8). Patents and Software

1. Li Guangdi, Huang Jie, Zhang Pan, Xiao Biao, Li Boqi, Liu Ying, Antiviral Drug Comprehensive Information Management System V1.0, 2023, Software ID: 12191868

(9). Journal Editors and Reviewers

1. Associate Editor: "Journal of Medical Virology" (IF: 7.7),

2. Editorial Board Member: "Scientific Reports" (IF: 4.6), "Viruses" (IF: 4.7), "Pharmaceutics" (IF: 5.4),

3. Reviewers: "BMC Medicine", "Science Advances", "Nature Communications", "Clinical infectious Diseases", "Journal of infection and public health", "Virology" and other SCI journals

(10). Recruitment of doctoral and postgraduate students 

Outstanding students are welcome to join our master and doctoral programs in Central South University. Fellowship and scholarship are available.