李明，教授，博士，材料物理系

中南大学材料科学与工程学院教授，国家“四青”人才， 博士生导师

课题组主页： https://ming-group.com/

Group Website: https://ming-group.com/

 https://orcid.org/0000-0002-2289-0222

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博士毕业于美国西弗吉尼亚大学

硕士毕业于浙江大学材料科学与工程学院

本科毕业于大连理工大学精细化工系

先后在美国圣母大学、麻省理工学院和约翰霍普金斯大学从事博士后研究工作。

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研究方向：

主要从事新型生物医用材料、生物传感器和体外检测等方面的基础研究和应用研究，在新型表面等离激元材料研制及表面等离激元学、用于体外检测的生物传感技术开发、以及高分辨共聚焦拉曼显微学等方面做了长期系统性研究。曾获得国家优秀自费留学生奖（2011）和美国激光医学和手术协会fellowship（2015）等多项奖。近年来，课题组在Science Advances、Nature Communications、Advanced Materials、Angewandte Chemie International Edition、ACS Nano、Advanced Functional Materials、Nano Letters、Coordination Chemistry Reviews、Chemical Engineering Journal、Small、Chemistry of Materials、Analytical Chemistry、Biosensors and Bioelectronics、ACS Sensors等主流学术期刊发表学术论文80余篇，SCI引用次数12000余次。

主要从事以下几个方面的研究：

1、新型生物医用材料；

2、生物传感器和医学体外检测，侧重于癌症等重大疾病的早期诊断检测；

3、可穿戴式生物传感器和医疗器械。

联系方式：liming0823 at csu.edu.cn 或liming0823 at gmail.com(at 用 @ 替代）。

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课程讲授

1.《生物材料》每年秋冬学期，64学时4学分，材料科学与工程学院材料国际专业和材料学院卓越班

2. 《生物医用材料及生物传感》每年秋冬学期，72学时，湘雅附二临床医学（五年制）卓越医生班

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代表性论文

（https://scholar.google.com/citations?hl=en&user=m5IrnO8AAAAJ&view_op=list_works&sortby=pubdate）

2024

•  Mingyang Chen, Yangcenzi Xie, Ming Li*

Molecular-Sieving Label-Free Surface-Enhanced Raman Spectroscopy for Sensitive Detection of Trace Small-Molecule 

 Biomarkers in Clinical Samples

Nano Letters 2024, DOI: 10.1021/acs.nanolett.4c02890

• Yu Wen, Ruoxuan Liu, Yangcenzi Xie, Xinyu Liu, Ming Li*

SERS Surgical Navigation with Postsurgical Immunotherapy of Local Microtumors and Distant Metastases

for Improved Anticancer Outcomes

Science Advances 2024, 10, eado2741

• Jin-Feng Yu, Jialian Li, Ming Li*

An Intramolecular Rotor-Bridged Dimeric Cyanine Photothermal Transducer for Efficient Near-Infrared II

Fluorescence Imaging-Guided Mitochondria-Targeted Phototherapy

ACS Sensors 2024, 9(7), 3581–3593

• Yu Wen, Ruoxuan Liu, Yangcenzi Xie, Ming Li*

Targeted SERS Imaging and Intraoperative Real-Time Elimination of Microscopic Tumors for Improved

Breast-Conserving Surgery

Advanced Materials 2024, 36(32), 2405253

• Jin‐Feng Yu, Yu Wen, Ming Li*

An Active Self-Mitochondria-Targeting Cyanine Immunomodulator for Near-Infrared II Fluorescence Imaging-Guided

Synergistic Photodynamic Immunotherapy

Advanced Healthcare Materials 2024, DOI: 10.1002/adhm.202401061

• Jin-Feng Yu#, Yu Wen#, Ming Li*

Sterically Twisted Mitochondria-Targeting Photosensitizers for Augmented Near-Infrared II Fluorescence-Guided

Photodynamic Immunotherapy

Advanced Functional Materials 2024, DOI: 10.1002/adfm.202402663

• Xiaoming Su, Xinyu Liu, Yuzhen Ouyang, Yangcenzi Xie, Mingyang Chen, Pan Chen, Jia Liu, Minghua Wu, 

Chien-hong Lin, Hong Zhong, Ming Li*

SERS lateral flow strip detection of serum biomarkers for noninvasive assessment of operative microwave

ablation outcomes of unresectable hepatocellular carcinoma

Chemical Engineering Journal 2024, 485, 149833

• Yaxuan Lu, Ming Li*

Rational Design of Near‐infrared II Plasmonic Optofunctional Materials for Diagnostic and Therapeutic Applications

 Advanced Functional Materials 2024, 38(18), 2312753

• Xinyu Liu, Xiaoming Su, Mingyang Chen, Yangcenzi Xie, Ming Li*

Self-calibrating surface-enhanced Raman scattering-lateral flow immunoassay for determination of

 amyloid-β biomarker of Alzheimer's disease

 Biosensors and Bioelectronics 2024, 245, 115840

• Renting Jiang#, Jianqin Li#, Linhu Li, Yaxuan Lu, Huiming Zhang, Ming Li*

Engineering Near-Infrared Plasmonic Spiky Gold Nanostructures for Highly Efficient Surface-Enhanced

Raman Spectroscopy-Guided Cancer Hyperthermia Therapy        

Advanced Functional Materials 2024, 34(1), 2307631

2023

• Renting Jiang, Linhu Li, Ming Li*

Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy

of Pulmonary Metastatic Breast Cancer

ACS Nano2023, 17(21), 22129–22144

• Yangcenzi Xie, MingyangChen, Xinyu Liu, Xiaoming Su, Ming Li*
  

Artificial Intelligence-Assisted Label-Free Spectroscopic Quantification of Global DNA Cytosine Methylation in

a Miniature Plasmonic Pickering Emulsion

Advanced Functional Materials 2023, 33(48), 2307091.

• Xiaoming Su, Yangcenzi Xie, Xinyu Liu, Mingyang Chen, Chao Zheng, Hong Zhong*, Ming Li*

Absolute Quantification of Serum Exosomes in Patients with an SERS-Lateral Flow Strip Biosensor for Noninvasive

Clinical Cancer Diagnosis

ACS Applied Materials & Interfaces 2023, 15(31), 37130–37142.

• Haitao Wang, Huiming Zhang, Beibei Shan, Renata Solarska, Ming Li*

Symmetry-Breaking Effects of Near-Infrared II Thermoplasmonics of Gold–Silica–Cuprous Selenide Hybrid

Nanoshells

Journal of Physical Chemistry C  2023, 127(22), 10757–10765.

• Huiming Zhang, Ting Zhu, Ming Li*

Quantitative Analysis of the Shape Effect of Thermoplasmonics in Gold Nanostructures

Journal of Physical Chemistry Letters 2023, 14 (16), 3853-3860.

• Bin Meng, Yong Xie, Le Chen, Haitao Wang, Ming Li,* Zhuxin Dong*

Apex-Confined Plasmonic Tip for High Resolution Tip-Enhanced Raman Spectroscopic Imaging of

 Carbon Nanotubes

ACS Applied Materials & Interfaces, 2023, 15(13), 16984–16990.

• Xiaoming Su, Xinyu Liu, Yangcenzi Xie, Mingyang Chen, Chao Zheng, Hong Zhong,* Ming Li* 
  

 Integrated SERS-Vertical Flow Biosensor Enabling Multiplexed Quantitative Profiling of Serological Exosomal

 Proteins in Patients for Accurate Breast Cancer Subtyping

 ACS Nano 2023, 17(1), 4077-4088.

• Xiaoming Su, Xinyu Liu, Yangcenzi Xie, Mingyang Chen, Hong Zhong,* Ming Li*

 Quantitative Label-Free SERS Detection of Trace Fentanyl in Biofluids with a Freestanding Hydrophobic Plasmonic

 Paper Biosensors

 Analytical Chemistry 2023, 95(7), 3821–3829.

• Mingyang Chen, Renata Solarska, Ming Li*

Additional Important Considerations in Surface-Enhanced Raman Scattering Enhancement Factor Measurements

Journal of Physical Chemistry C 2023, 127(5), 2728-2734. 

2022

• Yangcenzi Xie, Xiaoming Su, Yu Wen, Chao Zheng,* Ming Li*
  

Artificial intelligent label-free SERS profiling of serum exosomes for breast cancer diagnosis

and postoperative assessment

Nano Letters 2022, 22(19), 7910–7918.

• Linhu Li, Renting Jiang, Beibei Shan, Yaxuan Lu, Chao Zheng, Ming Li*

Near-infrared II plasmonic porous cubic nanoshells for in vivo noninvasive SERS visualization

of sub-millimeter microtumors

Nature Communications 2022, 13, 5249.

• Yangcenzi Xie, Yu Wen, Xiaoming Su, Chao Zheng, Ming Li*
  

Label-free plasmon-enhanced spectroscopic HER2 detection for dynamic therapeutic surveillance

of breast cancer

Analytical Chemistry 2022, 94(37), 12762–12771.

• Guangzhi Zhou, Ming Li*

Biodegradable copper telluride nanosheets for redox-homeostasis breaking-assisted chemodynamic

cancer therapy boosted by mild-photothermal effect

Chemical Engineering Journal 2022, 450, 138348

• Huyun Liu, Renting Jiang, Yaxuan Lu, Beibei Shan, Yu Wen, and Ming Li*
  

Biodegradable Amorphous Copper Iron Tellurite Promoting the Utilization of Fenton-like Ions 

for Efficient Synergistic Cancer Theranostics

ACS Applied Materials & Interfaces 2022, 14 (25), 28537-28547

• Beibei Shan, Yaxuan Lu, Chao Zheng, Ming Li*
  

Structural symmetry effects in plasmonic metal-semiconductor hybrid heterostructures for multimodal

cancer phototheranostics

Chemical Engineering Journal 2022, 444, 136707.

• Guangzhi Zhou, Ming Li*
  

Near‐infrared II plasmonic tri‐enzyme integrated metal‐organic frameworks with high‐efficiency enzyme 

cascades for synergistic tri‐modal oncotherapy

Advanced Materials 2022, 34(24), 2200871.

• Beibei Shan, Huyun Liu, Linhu Li, Yaxuan Lu, Ming Li*

Near-infrared II plasmonic phototheranostics with glutathione depletion for multimodal imaging-guided

hypoxia-tolerant chemodynamic-photocatalytic-photothermal cancer therapy triggered by a single laser

Small 2022, 18(4), 2105638. 

2021

• Yu Wen, Junjiao Hu, Jun Liu, Ming Li*
  

Degradable carrier-free metal−phenolic network theranostic agent with targeted mitochondrial damage for

efficient cancer theranostics

 Chemistry of Materials 2021, 33(17), 7089-7099. 

• Mengling Liao, Beibei Shan, Ming Li*

 Role of trap states in excitation wavelength-dependent photoluminescence of strongly quantum-confined

all-inorganic CsPbBr₃ perovskites with varying dimensionalities

Journal of Physical Chemistry C 2021, 125(38), 21062–21069.

• Jiayi Tan, Yu Wen, Ming Li*
  

Emerging biosensing platforms for quantitative detection of exosomes as diagnostic biomarkers

Coordination Chemistry Reviews 2021, 446, 214111

• Xi Wang, Changxu Liu, Congcong Gao, Kaili Yao, Seyed Shayan Mousavi Masouleh, Rodrigo Berté, Haoran Ren,

Leonardo de S Menezes, Emiliano Cortés, Isobel C Bicket, Haiyu Wang, Ning Li, Zhenglong Zhang, Ming Li, 

Wei Xie, Yifu Yu, Yurui Fang, Shunping Zhang, Hongxing Xu, Alberto Vomiero, Yongchang Liu, Gianluigi A Botton,

Stefan A Maier, Hongyan Liang

Self-Constructed Multiple Plasmonic Hotspots on an Individual Fractal to Amplify Broadband Hot Electron

Generation

ACS Nano2021, 15(6), 10553–10564.

• Jianqin Li, Hangduo Lin, Xiaolin Zhang, Ming Li*
  

Seed shape-controlled, facet-selective growth of superspiky gold nanocrystals for biosensing applications.

Journal of Materials Chemistry C 2021, 9, 8694-8704.

• Beibei Shan, Linhu Li, Yawen Zhao, Haitao Wang, Ming Li*
  

Near-infrared II plasmonic Au@Au-Ag dot-in-cubic nanoframes for in vivo surface-enhanced Raman

spectroscopic detection and photoacoustic imaging.

Advanced Functional Materials 2021, 31(29), 2103186.

• Haitao Wang, Ming Li*

Near-Infrared II thermoplasmonics of cuprous selenide multilayer nanoshells: the role of the plasmonic core. 

Journal of Physical Chemistry Letters 2021, 12, 4928-4935.

• Yu Wen, Vinh X. Truong, Ming Li*

Real-time intraoperative surface-enhanced Raman spectroscopy-guided thermosurgical eradication of

residual microtumors in orthotopic breast cancer

Nano Letters 2021, 21(7), 3066–3074.

• Caiju Chen, Huyun Liu, Haitao Wang, Yawen Zhao, Ming Li*

A scalable broadband plasmonic cuprous telluride nanowire-based hybrid photothermal membrane for

efficient solar vapor generation

Nano Energy 2021, 84, 105868.

2020

• Beibei Shan, Haitao Wang, Linhu Li, Guangzhi Zhou, Yu Wen, Mingyang Chen, Ming Li*

Rationally designed dual-plasmonic gold nanorod@cuprous selenide hybrid heterostructures by

regioselective overgrowth for in vivo photothermal tumor ablation in the second near-infrared biowindow

Theranostics 2020, 10(25), 11656-11672.

• Ming Li, Scott K. Cushing, Guangwen Zhou, Nianqiang Wu

Molecular hot spots in surface-enhanced Raman scattering

Nanoscale 2020, 12, 22036–22041.

• Ming Li*, Hangduo Lin, Santosh Kumar Paidi, Nicolas Mesyngier, Sarah P Preheim, Ishan Barman

A fluorescent and surface-enhanced Raman spectroscopic dual-modal aptasensor for sensitive detection

of cyanotoxins

ACS Sensors 2020, 5(5), 1419-1426.

• Ming Li*, Andrew P. Dove, Vinh Xuan Truong

Additive-Free Green Light-Induced Ligation Using BODIPY Triggers

Angewandte Chemie International Edition 2020, 59, 2284 –2288.

2019

• Beibei Shan, Yawen Zhao, Yiwen Li, Haitao Wang, Rui Chen, Ming Li*

High-Quality Dual-Plasmonic Au@Cu_2-xSe Nanocrescents with Precise Cu_2-xSe Domain Size Control and Tunable

Optical Properties in the Second Near-Infrared Biowindow

Chemistry of Materials 2019, 31, 9875-9886.

• Xiang Pan, Linhu Li, Hangduo Lin, Jiayi Tan, Haitao Wang, Mengling Liao, Caiju Chen, Beibei Shan,

Yingfan Chen, Ming Li*

A graphene oxide-gold nanostar hybrid based-paper biosensor for label-free SERS detection of serum

bilirubin for diagnosis of jaundice

Biosensors and Bioelectronics, 2019, 145, 111713.

• Ming Li,* Santosh Kumar Paidi, Eric Sakowski, Sarah Preheim and Ishan Barman*

Ultrasensitive Detection of Hepatotoxic Microcystin Production from Cyanobacteria Using Surface-Enhanced

Raman Scattering Immunosensor

ACS Sensors, 2019, 4, 1203-1210.

• Mengling Liao, Beibei Shan, Ming Li*

In Situ Raman Spectroscopic Studies of Thermal Stability of All-Inorganic Cesium Lead Halide (CsPbX3, X = Cl, Br, I)

Perovskite Nanocrystals

Journal of Physical Chemistry Letters 2019, 10 (6), 1217–1225.

2017,2018

• Beibei Shan, Yuhan Pu, Yingfan Chen, Mengling Liao, Ming Li*

Novel SERS Labels: Rational Design, Functional Integration and Biomedical Applications

Coordination Chemistry Reviews 2018, 371, 11-37.

• Qianru Jin# (co-first author), Ming Li# (co-first author), Beril Polat, Santosh K. Paidi, Aimee Dai, Amy Zhang,

Jayson V. Pagaduan, Ishan Barman, David H. Gracias

Mechanical Trap Surface‐Enhanced Raman Spectroscopy for Three‐Dimensional Surface Molecular Imaging of

Single Live Cells

Angewandte Chemie International Edition 2017, 56, 3822-3826.

Before 2016

• Ming Li*, Sangeeta Ray Banerjee, Chao Zheng, Martin G. Pomper, and Ishan Barman

Ultrahigh Affinity Raman Probe for Targeted Live Cell Imaging of Prostate Cancer

Chemical Science, 2016, 7, 6779-6785.

• Ming Li*, Jeon Woong Kang, Saraswati Sukumar, Ramachandra R. Dasari, and Ishan Barman

Multiplexed Detection of Serological Cancer Markers with Plasmon-Enhanced Raman Spectro-immunoassay

Chemical Science, 2015, 6, 3906-3914.

• Ming Li, Jeon Woong Kang, Ramachandra Rao Dasari, and Ishan Barman

Shedding Light on the Extinction-Enhancement Duality in Gold Nanostar-Enhanced Raman Spectroscopy

Angewandte Chemie International Edition, 2014, 53, 14115-14119.

• Scott K. Cushing# (co-first author), Ming Li# (co-first author), Fuqiang Huang, and Nianqiang Wu

Origin of Strong Excitation Wavelength Dependent Fluorescence of Graphene Oxide

ACS Nano, 2014, 8, 1002-1013.

• Ming Li, Scott K. Cushing, Jianming Zhang, Savan Suri, Rebecca Evans, William P. Petros, Laura F. Gibson,

Dongling Ma, Yuxin Liu, and Nianqiang Wu

Three-Dimensional Hierarchical Plasmonic Nano-architecture Enhanced Surface-Enhanced Raman Scattering

Immuno-Sensor for Cancer Biomarker Detection in    Blood Plasma

ACS Nano, 2013, 7, 4967-4976.

• Ming Li, Scott K. Cushing, Hongyan Liang, Savan Suri, Dongling Ma, and Nianqiang Wu

Plasmonic Silver Nanorice Antenna on Gold Triangle Nano-array for Surface-Enhanced Raman Scattering

Detection of Hepatitis B Virus DNA

Analytical Chemistry, 2013, 85, 2072-2078.

• Ming Li, Xuejiao Zhou, Shouwu Guo, and Nianqiang Wu

Detection of Lead (II) with a “Turn-On” Fluorescent Sensor Based on Energy Transfer from CdSe/ZnS

Quantum Dots to Graphene Oxide

Biosensors & Bioelectronics, 2013, 43, 69-74.

• Ming Li, Xuejiao Zhou, Weiqiang Ding, Shouwu Guo, and Nianqiang Wu

Fluorescent Aptamer-Functionalized Graphene Oxide for Label-Free Detection of Mercury (II)

Biosensors & Bioelectronics, 2013, 41, 889-893.

• Ming Li, Xuejiao Zhou, Shouwu Guo, and Nianqiang Wu

Fingerprinting Photoluminescence of Functional Groups in Graphene Oxide

Journal of Materials Chemistry, 2012, 22, 23374-23379.

• Ming Li, Qiaoyi Wang, Xiaodong Shi, Lawrence A. Hornak, and Nianqiang Wu

Detection of Mercury (II) by Quantum dot-DNA-Gold Nanoparticle Ensemble Based Nanosensor via Nanometal

Surface Energy Transfer

Analytical Chemistry, 2011, 83, 7061-7065.

• Ming Li, Scott K. Cushing, Qiaoyi Wang, Xiaodong Shi, Lawrence A. Hornak, Zhanglian Hong, and Nianqiang Wu

Size-dependent Energy Transfer between CdSe/ZnS Quantum Dots and Gold Nanoparticle

Journal of Physical Chemistry Letters, 2011, 2, 2125-2129.