个人简介
刘元东，湖南邵阳人，博士，国家科技部和自然科学基金委评审专家、教育部科技和学位评审专家、湖南省和广东省科技评审专家、长沙市科技评审专家，国际生物湿法冶金学会秘书、Frontiers in Bioscience-Landmark、Frontiers in Bioleaching等国际杂志编委及审稿人。主持或参与国家级省部级等项目10多项，发表SCI论文60多篇，获得专利30多项，获得软件著作权20多项，获得省级等奖励荣誉多项。指导研究生数十名，获研究生国家奖等。
联系方式：
邮箱：yuandong_liu@csu.edu.cn
QQ邮箱：438320825@qq.com
电话：0731-88877472
地址：湖南省长沙市岳麓区麓山南路932中南大学生物楼
工作教育经历：
工作：中南大学，资源加工与生物工程学院，生物系，教学科研
海外留学：美国加州大学，结构生物学与生物传感器应用研究
博士：中南大学，生物工程专业，生物冶金及其生物信息学与蛋白表达纯化鉴定方向
硕士：中南大学，材料学专业，无机材料及其设计与人工智能软件开发方向
本科：中南大学，无机非金属材料专业，计算机在材料中的应用方向
研究方向：
（1）蛋白质功能结构解析
（2）生物传感器与环境监测
（3）生物冶金与极端环境微生物
（4）多层生物组学、生物信息学与软件开发
（5）生物材料与抗菌材料
（6）矿物资源处理及其污染治理
科研项目：
（1）新颖银离子陷阱蛋白的分子作用机制及其荧光生物传感器应用基础，长沙市自然科学基金，主持
（2）氮化硅特种陶瓷材料的生物相容性和抗菌性研究，企业合作项目，主持
（3）生物浸矿过程微生物的高密度培育，国家自然科学基金面上项目，主持
（4）冶金微生物信息学高通量大数据云计算平台的研制，湖南省自然科学基金面上项目，主持
（5）嗜酸氧化亚铁硫杆菌浸矿过程胞外多糖的形成、组成与功能研究，湖南省自然科学基金面上项目，主持
（6）基于生物信息学的嗜酸氧化亚铁硫杆菌浸矿过程能量传递体系的研究，国家自然科学基金项目，主持
（7）外加碳氮氧源强化生物浸矿铁硫氧化过程研究，中国博士后科学基金特别资助项目，主持
（8）生物浸矿过程微生物群落铁硫氧化机理研究，中国博士后科学基金面上项目，主持
（9）嗜酸氧化亚铁硫杆菌全基因组序列的生物信息学挖掘及比较，中南大学引进人才基金项目，主持
（10）微生物冶金过程强化的基础研究，国家重大基础研究项目，参与
（11）微生物冶金的基础研究，国家重大基础研究，参与
（12）硫化矿生物提取的基础研究，国家自然科学基金创新群体项目，参与
学术论文：
Xiangdong Shangguan, Yuandong Liu*, Run Liu, Kan Wang, Wissal Belqadi, Jiayu He, Yan Tong, Li Shen, Weimin Zeng, Xueling Wu, Runlan Yu, Xinlei Sun.Enhanced Chalcopyrite Dissolution in Acidic Culture Medium: The Impact of Arsenopyrite Presence，Minerals,2024, 14, 50.
Jiayu He; Yuandong Liu*; Xiaofeng Zeng; Yan Tong;Run Liu;Kan Wang;Xiangdong Shangguan;Guanzhou Qiu;Coswald Stephen Sipaut.Silicon Nitride Bioceramics Sintered by Microwave Exhibit Excellent Mechanical Properties, Cytocompatibility In Vitro, and Anti-Bacterial Properties，Journal of Functional Biomaterials, 2023, 14(11): 552-
Yuandong Liu,Jiayu He,Xiangdong Shangguan,Run Liu,Xiaofeng Zeng,Wissal Belqadi,Kan Wang,Yan Tong,Runlan Yu,Weimin Zeng,Xueling Wu,Li Shen and Guanzhou Qiu.Purification,Characterization,and Ferrous Oxidation Kinetics of Iron Oxidase from Acidithiobacillus ferridurans.Separations, 2023, 10(11):554.
Yuandong Liu, Xiangdong Shangguan, Jingying Ouyang, Jiayu He,Kan Wang,Yan Tong,Runlan Yu,Weimin Zeng,Xueling Wu,Li Shen and Guanzhou Qiu.Expression, Purification and Characterization of a Novel Rusticyanin from the Psychrotolerant Acidithiobacillus ferrivorans.Separations,2023,10,448.
Ying Qi, Xiangdong Shangguan, Jiayu He, Lixiang Chen, Jing Jin, Yuandong Liu*,Guanzhou Qiu, Runlan Yu, Jiaokun Li, Weimin Zeng, Li Shen, Xueling Wu. Expression, purification, characterization and direct electrochemistry of two HiPIPs from Acidithiobacillus caldus SM-1. Analytical Biochemistry, 2022,(650), 114724.
Runlan Yu, Meilian Man, Zhaojing Yu, Xueling Wu, Li Shen, Yuandong Liu, Jiaokun Li, Mingchen Xia, Weimin Zeng. A high‑efciency Klebsiella variicola H12‑CMC‑FeS@biochar for chromium removal from aqueous solution. Scientifc Reports,(2021) 11:6611.
Zeng W, Li F, Wu C, Yu R, Wu X, Shen L, et al. Role of extracellular polymeric substance (EPS) in toxicity response of soil bacteria Bacillus sp. S3 to multiple heavy metals[J]. Bioprocess and Biosystems Engineering. 2020,43(1):153-67.
Yu R, Wang S, Wu X, Shen L, Liu Y, Li J, et al. Community structure variation associated with airborne particulate matter at central south of China during hazy and nonhazy days. Atmospheric Pollution Research. 2020,11(6):162-9.
Xia M, Bao P, Peng T, Liu A, Shen L, Yu R, et al. Exploration of potential jarosite biomineralization mechanism based on extracellular polymer substances of Purpureocillium lilacinum Y3. International Biodeterioration and Biodegradation. 2020,150.
Wu XL, Wu XY, Deng FF, Shen L, Li JK, Peng TJ, et al. Comparison of bioleaching of chalcopyrite concentrates with mixed culture after cryopreservation with PEG-2000 in liquid nitrogen[J]. Journal of Central South University. 2020,27(5):1386-94.
Wang J, Huang J, Xu M, Li Z, Fan L, Chen R, et al. A composite FeOOH@microalgae for heavy metals and Congo red removal from aqueous solution. Desalination and Water Treatment. 2020,191:263-84.
Li J, Gu T, Li L, Wu X, Shen L, Yu R, et al. Complete genome sequencing and comparative genomic analyses of Bacillus sp. S3, a novel hyper Sb(III)-oxidizing bacterium. BMC Microbiology. 2020,20(1).
Gu T, Yu H, Li F, Zeng W, Wu X, Shen L, et al. Antimony-oxidizing bacteria alleviate Sb stress in Arabidopsis by attenuating Sb toxicity and reducing Sb uptake[J]. Plant and Soil. 2020,452(1-2):397-412.
WANG Mingwei,LIANG Jiaqila,ZENG Weimin, YU Yunlan,LI Jiaokun,SHEN Li, WU Xueling, HUANG Caoming,QIN Wenqing, LIU Yuandong. Bioleaching of tin-rich polymetallic sulphide ore by Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans. Nonferrous Metals Science and Engineering , 2018, 9(3):76-83.
Yuandong Liu, Le Yuan, Runlan Yu. Overview of high-cell-density cultivation of microorganisms. Nonferrous Metals Science and Engineering, 2015,6(4): 76-80.
Liu yuandong, Guo shuhui, Yu runlan. Differential gene expression and bioinformatics analysis of a cytochrome c family gene of afe_0378 in Acidithiobacillus ferrooxidans. Journal of Microbiology.2014.1,34(2):34-48.
Yuandong Liu, Shuhui Guo, Runlan Yu, Guanzhou Qiu. A new cytoplasmic monohaem cytochrome c from Acidithiobacillus ferrooxidans involved in sulfur oxidation. Current Microbiology. MAR 2014, 68(3): 285-292.
Yuandong Liu, Shuhui Guo, Runlan Yu, Jiaju Ji, Guanzhou Qiu. HdrC2 from Acidithiobacillus ferrooxidans owns two iron-sulfur binding motifs but binds only one variable cluster between [4Fe-4S] and [3Fe-4S]. Current Microbiology. JAN 2013, 66(1): 88-95.
Yuandong Liu, Jiaju Ji, Runlan Yu, Guanzhou Qiu. Expression, purification and molecular modeling of another HdrC from Acidithiobacillus ferrooxidans which binds only one [4Fe-4S] cluster. Current Microbiology. OCT 2012,: 65( 4): 16-423.
Yuandong Liu, Guanzhou Qiu. Mesophilic bioleaching of chalcopyrite concentrate mixed with limestone. Minerals Engineering. 2012.6
Qi Hu, Xueling Wu, Ying Jiang, Yuandong Liu, Yili Liang, Xueduan Liu, Huaqun Yin, Ngom Baba. Differential gene expression and bioinformatics analysis of copper-resistance gene afe_1073 in Acidithiobacillus ferrooxidans. Biological Trace Element Research. 2013,152(1):91-97.
Cheng-gui Zhang, Jin-lan Xia, Yuan-dong Liu, Huan He, Guan-zhou Qiu. The putative thiol-disulphide interchange protein DsbG from Acidithiobacillus ferrooxidans has disulphide isomerase activity. SCIENCEASIA, 2010, Volume: 36, Issue: 2, Pages: 100-104.
Wu Xue-ling, Miao Bo, Han Jian, Hu Qi, Zeng Jia, Liu Yuan-dong, Qiu Guan-zhou. Purification and enzymatic properties of arsenic resistance protein ArsH from heterogeneous expression in E. coli BL21 . TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA, 2010. Volume: 20, Issue: 10, Pages: 1987-1992.
Chenbing Ai, Hongyu Mo, Chen, Qian Chen, Yuandong Liu, Lin Tang, Juan Du, Jia Zeng. Expression, Purification, and Characterization of an Iron Chaperon Protein CyaY from Acidithiobacillus ferrooxidans. CURRENT MICROBIOLOGY. Volume: 62, Issue: 3,Pages: 733-738.
Yuandong Liu, Guanzhou Qiu. Structure prediction and docking study of RpiA from extremophile Acidithiobacillus ferrooxidans. Biohydrometallurgy: Biotech key to unlock mineral resources value (Proceedings of the 19th International Biohydrometallurgy Symposium). 393-399. September 18-22,2011.
Yuandong Liu, Guanzhou Qiu, Weimin Zeng. Grand Challenges for Bioleaching. Biohydrometallurgy: Biotech key to unlock mineral resources value (Proceedings of the 19th International Biohydrometallurgy Symposium). 341-343. September 18-22,2011.
CHEN Fengju，LIU Yuandong，GAO Jian，SUN Yuandon. Homology Modeling of RpiA from Acidithiobacillus ferrooxidans. ACTA SCIENTIARUM NATURALIUM UNIVERSITATIS SUNYATSENI. 49 (4): 294-300. Jul. 2010
Jia Zeng, Qing Liu, Xiaojian Zhang, Hongyu Mo, Yiping Wang, Qian Chen, Yuandong Liu. Functional Roles of the Aromatic Residues in the Stabilization of the [Fe4S4] Cluster in the Iro Protein from Acidithiobacillus ferrooxidans. Journal of Microbiology and Biotechnology, 20 (2): 294-300 FEB 2010
Yuandong Liu, Leping Zeng，Guanzhou Qiu*. Homology modeling and substrate binding study of glutathione reductase from Acidithiobacillus ferrooxidans. Progress in Modern Biomedicine. 2009,9(3):401-406
Yanjie Luo, Chenggui Zhang, Yuandong Liu, Xueling Wu, Hao Guan, Hehuan Liao, Hailang Luo, Xueduan Liu, Guanzhou Qiu. Differences between two copper related genes in the genome of Acidithiobacillus ferrooxidans. Biotechnology. 2009,19(2): 9-13
Chunli Zheng, Yanfei Zhang, Yuandong Liu, Anna Wu, Lexian Xia, Jia Zeng, Jianshe Liu,Guanzhou Qiu. Characterization and Reconstitute of a [Fe4S4] Adenosine 5 '-Phosphosulfate Reductase from Acidithiobacillus ferrooxidans. Current Microbiology, 2009,58 (6): 586-592. JUN 2009
Yuandong Liu，Jian Gao, Jia Zeng, Chenggui Zhang, Xudong Ou Yang, Guanzhou Qiu* . Expression, purification and molecular modeling of iron-containing superoxide dismutase from Acidithiobacillus ferrooxidans. Transactions of Nonferrous Metals Society of China.Volume 18, Issue 6, December 2008, Pages 1361-1366
WU An-na, ZHANG Yan-fei, ZHENG Chun-li, DAI Yun-jie, LIU Yuan-dong , ZENG Jia, GU Guo-hua, LIU Jian-she. Purification and enzymatic characteristics of cysteine desulfurase, IscS, in Acidithiobacillus ferrooxidans ATCC 23270. Transactions of Nonferrous Metals Society of China.Volume 18, Issue 6, December 2008, Pages 1450-1457
LIU Yuan-dong, QIU Guan-zhou*, WANG Hai-dong, JIANG Ying, ZHANG Cheng-gui, XIA Le-xian. Full Structure building and docking studies of NifS from extremophile Acidithiobacillus ferrooxidans.Transactions of Nonferrous Metals Society of China. 2008, 18(4):995-1002. AUG 2008
Jia Zeng,Long Wu, Xiaojian Zhang,Yuandong Liu,Guisheng Deng, Ding Li . Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase. Organic Letters. 2008，10(19):4287-4290. OCT 2 2008
Yanjie Luo, Yuandong Liu, Chenggui Zhang, Hailang Luo, Hao Guan, Hehuan Liao, Guanzhou Qiu, Xueduan Liu. Insights into two high homogenous genes involved in copper homeostasis in Acidithiobacillus ferrooxidans.Current Microbiology. 2008, 57(4): 274-280. OCT 2008
Huidan Jiang, Zhang, Xiaojian Zhang, Chenbing Ai, Yuandong Liu, Jianshe Liu, Guanzhou Qiu, Jia Zeng. Asp97 is a crucial residue involved in the ligation of the [Fe4S4] cluster of IscA from Acidithiobacillus ferrooxidans. Journal of Microbiology and biotechnology. 2008,18 (6): 1070-1075. JUN 2008
[13] Jia Zeng, Huidan Jiang, Yuandong Liu, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of a high potential iron-sulfur protein from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2008, 30(5): 905-910. MAY 2008
LIU Yuan-dong, DING Jian-nan, QIU Guan-zhou*, WANG Hai-dong. Homology modeling and docking studies of IscS from extremophile Acidithiobacillus ferrooxidans. Journal of Central South University of Technology. 2007, 14(6):742-749. DEC 2007
Jia Zeng, Yuandong Liu, Long Wu, Ding Li. Mutation of Tyr375 to Lys375 allows medium-chain acyl-CoA dehydrogenase to acquire acyl-CoA oxidase activity. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 2007,1774(12): 1628-1634. DEC 2007
LIU Yuan-dong, WANG Hai-dong, QIU Guan-zhou*. Homology modeling and evolutionary trace analysis of superoxide dismutase from extremophile Acidithiobacillus ferrooxidans. Journal of Central South University of Technology. 2007, 14(5):612-617. OCT 2007
Jia Zeng, Xia Huang, Yuandong Liu, Jianshe Liu, Guanzhou Qiu. Expression, Purification, and Characterization of a [Fe(2)S(2)] Cluster Containing Ferredoxin from Acidithiobacillus ferrooxidans. Current Microbiology. 2007,55(6):518-523. DEC 2007
Jia Zeng, Wenjie Zhao, Yuandong Liu, Lexian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of an iron-sulfur cluster assembly protein, IscU, from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2007, 29(12):1965-1972. DEC 2007
Jia Zeng, Yanfei Zhang, Yuandong Liu, Xiaojian Zhang, Leixian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and characterization of a cysteine desulfurase, IscS, from Acidithiobacillus ferrooxidans. Biotechnology Letters. 2007, 29(12):1983-1990. DEC 2007
Jia Zeng, Meimei Geng, Huidan Jiang, Yuandong Liu, Jianshe Liu,Guanzhou Qiu. The IscA from Acidithiobacillus ferrooxidans is an iron–sulfur protein which assemble the [Fe4S4] cluster with intracellular iron and sulfur. Archives of Biochemistry and Biophysics. 2007, 463(2):237-244. JUL 15 2007
Jia Zeng, Meimei Geng, Yuandong Liu, Lexian Xia, Jianshe Liu,Guanzhou Qiu. The sulfhydryl group of Cys138 of rusticyanin from Acidithiobacillus ferrooxidans is crucial for copper binding. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics. 2007, 1774(4): 519-525. APR 2007
Jia Zeng, Meimei Geng, Yuandong Liu, Wenjie Zhao, Lexian Xia, Jianshe Liu, Guanzhou Qiu. Expression, purification and molecular modelling of the Iro protein from Acidithiobacillus ferrooxidans Fe-1. Protein Expression and Purification. 2007, 52(1):146-152. MAR 2007
软件开发：
浸矿环境微生物信息学大数据平台框架系统，软件著作权登记号：2021SR0251361
电子传递氧化还原蛋白反应动力学模拟与数据分析程序系统，软件著作权登记号：2021SR0424913
反向传播人工神经网络建模软件系统，软件著作权登记号：2019SR0167159
水泥熟料煅烧质量人工神经网络预报系统，软件著作权登记号：2018SR904579
蒙脱石钠化改型神经网络预报软件，软件著作权登记号：2018SR955240
生物冶金菌种资源信息平台系统，软件著作权登记号：2019SR0393187
国际生物湿法冶金学会信息平台系统，软件著作权登记号：2019SR0187548
第19届国际生物湿法冶金大会网络服务英文平台系统，软件著作权登记号：2018SR1067535
生物冶金实验室信息发布平台系统，软件著作权登记号：2016SR074704
多功能国际化实时柔性高效网站框架系统，软件著作权登记号：2016SR073302，
获奖荣誉：
中度高温环境下冶金微生物菌种选育及其硫化矿浸出机理，湖南省科学技术奖励工作办公室，2014年度湖南省自然科学奖( 二等奖 )，2014
应用驱动的生物信息学教学创新，教育基础课程改革教研成果，中国教育发展学会，2013