›国家自然科学基金委:运动康复干预对骨腱界面损伤修复的力学调控机制研究(82230085),吕红斌,立项时间:2022-09-29,结项时间:2027-12-31.

›国家自然科学基金委:下丘脑室旁核-交感神经调控轴在肩袖骨腱界面损伤修复中的作用及干预策略研究(82272572),吕红斌,立项时间:2022-09-29,结项时间:2027-12-31.

›国家自然科学基金（国家级）:力学刺激介导局部微环境对干细胞的调节及其在骨腱界面损伤修复中的作用研究,吕红斌

›湘雅医院-北大未名临床与康复研究基金:运动系统常见损伤的原因分析与预防策略,吕红斌

›国家自然科学基金（国家级）:新型骨-软骨-肌腱三相书页支架对骨腱连接点损伤后梯度结构再生的作用及相关机制研究,吕红斌

›湖南省科学技术厅科技计划 （省级重点项目）:运动医学临床大数据系统,吕红斌

›湖南省科学技术厅科技计划 （省级重点项目）:基于纳米载体的控释抗菌骨修复活性材料抑菌性能及生物学检测,吕红斌

›湖南省科技基本建设项目投资计划（湖南省发改委资助）（省级）:低强度脉冲超声治疗骨腱连接点损伤产业技术前期研究,吕红斌

›美国DJO. LLC. Research Fund 资助（国际合作）:Combined Magnetic Field for Accelerating Bone-Tendon Junction Repair,吕红斌

›国家自然科学基金（国家级）:低强度脉冲超声治疗骨腱连接点损伤相关分子机制的研究——不同治疗起始时间的效应,吕红斌

›教育部高等学校博士学科点专项科研基金（部级）:骨腱连接点损伤炎症反应期超声治疗的分子机制探讨,吕红斌

›美国Aspen Research Fund 资助（国际合作）:Comparison of Inelastic and Elastic Lumbosacral Orthoses on Low Back Pain Prevention in Hospital Nurses.,吕红斌

›教育部科学技术研究重点项目(部级重点):低强度脉冲超声修复骨-腱连接点损伤的机制--比较蛋白质组学研究,吕红斌

›中国科学院上海应用物理研究所:利用X 射线相位衬度CT观察兔骨腱连接点损伤愈合界面纤维软骨层和软骨性化生区的形态学特点,吕红斌

›湖南省发展与改革委员会科研基金(省级):利用电磁场疗法修复骨-腱连接点损伤,吕红斌

›中南大学前沿研究计划项目-前沿探索与交流研究:骨腱连接点损伤修复的相关分子机制研究,吕红斌

›湖南省科技厅国际科技合作项目:中美联合研究生物物理刺激仪治疗骨-腱连接点的损伤,吕红斌

›卫生计划管理委员会:运动医学国家临床重点专科,吕红斌

›1.A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair.Advanced Science

›2.Central microglia-adenosine-related signaling impairs bone-tendon interface repair via sympathetic ADRB2 activation.J Neuroinflammation

›3.Single cell atlas decodes the molecular dynamics of scar repair after human rotator cuff tear.Bone Res

›4.Identification of a new population of Tnn+ progenitors to form tendon enthesis fibrocartilage.Bone Research

›5.Histone H3K9 Lactylation Activates the TXNIP/NLRP3 Pathway to Drive Macrophage Inflammation after Spinal Cord Injury.Redox Biology

›6.Hypoxic Neural Stem Cells Enhance Spinal Cord Repair Through HIF-1a/RAB17-Driven Extracellular Vesicle Release.J Extracell Vesicles

›7.Extracellular vesicle-mediated spinal cord-brain crosstalk induces hippocampal neurogenesis impairment and cognitive deficits post-spinal cord injury.Theranostics

›8.KDM6A/MMP-3 epigenetic axis governs macrophage senescence after spinal cord injury for mediating the regenerative niche to promote neurological repair.J Adv Res

›9.Engineered lesion-homing liposomes encapsulating Rosuvastatin enhance spinal cord injury repair by preventing the formation of foamy macrophages.J Control Release

›10.Dissolvable microneedle-based wound dressing transdermally and continuously delivers anti-inflammatory and pro-angiogenic exosomes for diabetic wound treatment.Bioact Mater

›11.3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration.Bioact Mater

›12.Extracellular vesicles secreted by LRP1+ ligament-derived stem cells promote tendon-bone healing after ACL reconstruction via miR-708-5p/Bambi axis.Biomaterials

›13.Injectable decellularized Wharton's jelly hydrogel containing CD56+ umbilical cord mesenchymal stem cell-derived exosomes for meniscus tear healing and cartilage protection.Mater Today Bio

›14.Deciphering the heterogeneity of calcified structure in different entheses via high-resolution characterization techniques.Acta Biomater

›15.The effects of exercise on pain and anxiety following rotator cuff injury: the role of paraventricular nucleus synaptic plasticity.J Orthop Translat

›16.Exosomes from CD133+CD271+ human urine-derived stem cells combined with a novel photosensitive hydrogel promote repair after spinal cord injury.J Transl Med

›17.Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.Nat Commun

›18.Endothelial Foxo1 Phosphorylation Inhibition via Aptamer-Liposome Alleviates OPN-Induced Pathological Vascular Remodeling Following Spinal Cord Injury.Adv Sci (Weinh)

›19.MCT1-mediated endothelial cell lactate shuttle as a target for promoting axon regeneration after spinal cord injury.Theranostics

›20.The effects of primary cilia-mediated mechanical stimulation on nestin+-BMSCs during bone-tendon healing.J Adv Res

›21.Dual-functional gallium/chitosan/silk/umbilical cord mesenchymal stem cell exosome sponge scaffold for diabetic wound by angiogenesis and antibacteria.Int J Biol Macromol

›22.Exosomes derived from bone marrow mesenchymal stem cell preconditioned by low-intensity pulsed ultrasound stimulation promote bone-tendon interface fibrocartilage regeneration and ameliorate rotator cuff fatty infiltration.J Orthop Translat

›23.Advances in X-ray neuroimaging: Bridging scales from molecular to organ architectures.TrAC Trends in Analytical Chemistry

›24.Comparative effect of skeletal stem cells versus bone marrow mesenchymal stem cells on rotator cuff tendon-bone healing.J Orthop Translat

›25.Engineering a functional ACL reconstruction graft containing a triphasic enthesis-like structure in bone tunnel for the enhancement of graft-to-bone integration.J Orthop Translat

›26.Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair.Bone Res

›27.Intranasal delivery of small extracellular vesicles from specific subpopulation of mesenchymal stem cells mitigates traumatic spinal cord injury.J Control Release

›28.Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury.Cell Commun Signal

›29.A Combined Treatment of BMP2 and Soluble VEGFR1 for the Enhancement of Tendon-Bone Healing by Regulating Injury-Activated Skeletal Stem Cell Lineage.Am J Sports Med

›30.Exosomes derived from CD271+CD56+ bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury.Theranostics

›31.Optimized Allogenic Decellularized Meniscal Scaffold Modified by Collagen Affinity Stromal Cell-Derived Factor SDF1α for Meniscal Regeneration: A 6- and 12-Week Animal Study in a Rabbit Model.Am J Sports Med

›32.Local delivery of EGFR+NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway.Bioact Mater

›33.Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation.Elife

›34.Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis.Bioact Mater

›35.Inhibition of UTX/KDM6A improves recovery of spinal cord injury by attenuating BSCB permeability and macrophage infiltration through the MLCK/p-MLC pathway.J Neuroinflammation

›36.Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood-Spinal Cord Barrier Repair after Spinal Cord Injury.ACS Nano

›37.UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury.J Nanobiotechnology

›38.The effect of local sympatholysis on bone-tendon interface healing in a murine rotator cuff repair model.J Orthop Translat

›39.Activating Mitochondrial Sirtuin 3 in Chondrocytes Alleviates Aging-Induced Fibrocartilage Layer Degeneration and Promotes Healing of Degenerative Rotator Cuff Injury.Am J Pathol

›40.TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis.Bone Joint Res

›41.Rotator cuff healing is regulated by the lymphatic vasculature.J Orthop Translat

›42.Mechanical stimulation improves rotator cuff tendon-bone healing via activating IL-4/JAK/STAT signaling pathway mediated macrophage M2 polarization.J Orthop Translat

›43.Mechanical stimulation promotes enthesis injury repair by mobilizing Prrx1+ cells via ciliary TGF-β signaling.Elife

›44.Engineering an enthesis-like graft for rotator cuff repair: An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers.Bioact Mater

›45.Characterize the microstructure change after tendon enthesis injury using synchrotron radiation μCT.J Orthop Res

›46.Early treadmill running delays rotator cuff healing via Neuropeptide Y mediated inactivation of the Wnt/β-catenin signaling.J Orthop Translat

›47.Effectiveness and Safety of Inelastic Versus Elastic Lumbosacral Orthoses on Low Back Pain Prevention in Healthy Nurses: A Randomized Controlled Trial.Spine (Phila Pa 1976)

›48.Calcitonin Gene-Related Peptide Influences Bone-Tendon Interface Healing Through Osteogenesis: Investigation in a Rabbit Partial Patellectomy Model.Orthop J Sports Med

›49.The Long Non-coding RNA NEAT1/miR-224-5p/IL-33 Axis Modulates Macrophage M2a Polarization and A1 Astrocyte Activation.Mol Neurobiol

›50.Effect of Exercise Intensity on the Healing of the Bone-Tendon Interface: A Mouse Rotator Cuff Injury Model Study.Am J Sports Med

›51.Recombinant human bone morphogenetic protein-4 enhances tendon-to-bone attachment healing in a murine model of rotator cuff tear.Ann Transl Med

›52.Cell-Free Book-Shaped Decellularized Tendon Matrix Graft Capable of Controlled Release of BMP-12 to Improve Tendon Healing in a Rat Model.Am J Sports Med

›53.Characterization of the distributions of collagen and PGs content in the decellularized book-shaped enthesis scaffolds by SR-FTIR.BMC Musculoskelet Disord

›54.The Enhancement Effect of Acetylcholine and Pyridostigmine on Bone-Tendon Interface Healing in a Murine Rotator Cuff Model.Am J Sports Med

›55.Acceleration of Bone-Tendon Interface Healing by Low-Intensity Pulsed Ultrasound Is Mediated by Macrophages.Phys Ther

›56.UTX/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration.Mol Ther Methods Clin Dev

›57.Effect of book-shaped acellular tendon scaffold with bone marrow mesenchymal stem cells sheets on bone-tendon interface healing.J Orthop Translat

›58.Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis.Stem Cell Res Ther

›59.A combinatorial method to visualize the neuronal network in the mouse spinal cord: combination of a modified Golgi-Cox method and synchrotron radiation micro-computed tomography.Histochem Cell Biol

›60.Designing a novel vacuum aspiration system to decellularize large-size enthesis with preservation of physicochemical and biological properties.Ann Transl Med

›61.Utx Regulates the NF-κB Signaling Pathway of Natural Stem Cells to Modulate Macrophage Migration during Spinal Cord Injury.J Neurotrauma

›62.Treadmill running initiation times and bone-tendon interface repair in a murine rotator cuff repair model.J Orthop Res

›63.Periosteum progenitors could stimulate bone regeneration in aged murine bone defect model.J Cell Mol Med

›64.3D-Printed Extracellular Matrix/Polyethylene Glycol Diacrylate Hydrogel Incorporating the Anti-inflammatory Phytomolecule Honokiol for Regeneration of Osteochondral Defects.Am J Sports Med

›65.SRμCT Reveals 3D Microstructural Alterations of the Vascular and Neuronal Network in a Rat Model of Chronic Compressive Thoracic Spinal Cord Injury.Aging Dis

›66.Functional decellularized fibrocartilaginous matrix graft for rotator cuff enthesis regeneration: A novel technique to avoid in-vitro loading of cells.Biomaterials

›67.Sustained release of collagen-affinity SDF-1α from book-shaped acellular fibrocartilage scaffold enhanced bone-tendon healing in a rabbit model.J Orthop Res

›68.Treadmill exercise facilitated rotator cuff healing is coupled with regulating periphery neuropeptides expression in a murine model.J Orthop Res

›69.Structure and ingredient-based biomimetic scaffolds combining with autologous bone marrow-derived mesenchymal stem cell sheets for bone-tendon healing.Biomaterials

›70.Comparison of bone surface and trough fixation on bone-tendon healing in a rabbit patella-patellar tendon injury model.J Orthop Translat

›71.Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis.Exp Biol Med (Maywood)

›72.UTX/KDM6A Deletion Promotes Recovery of Spinal Cord Injury by Epigenetically Regulating Vascular Regeneration.Mol Ther

›73.Autologous Freeze-Dried, Platelet-Rich Plasma Carrying Icariin Enhances Bone-Tendon Healing in a Rabbit Model.Am J Sports Med

›74.Synchrotron radiation micro-tomography for high-resolution neurovascular network morphology investigation.J Synchrotron Radiat

›75.Comparative Evaluation of the Book-Type Acellular Bone Scaffold and Fibrocartilage Scaffold for Bone-Tendon Healing.J Orthop Res

›76.Unilateral Osteotomy of Lumbar Facet Joint Induces a Mouse Model of Lumbar Facet Joint Osteoarthritis.Spine (Phila Pa 1976)

›77.Silencing of lncRNA PKIA-AS1 Attenuates Spinal Nerve Ligation-Induced Neuropathic Pain Through Epigenetic Downregulation of CDK6 Expression.Front Cell Neurosci

›78.Effect of Low-Intensity Pulsed Ultrasound After Autologous Adipose-Derived Stromal Cell Transplantation for Bone-Tendon Healing in a Rabbit Model.Am J Sports Med

›79.Book-shaped decellularized tendon matrix scaffold combined with bone marrow mesenchymal stem cells-sheets for repair of achilles tendon defect in rabbit.J Orthop Res

›80.Book-Shaped Acellular Fibrocartilage Scaffold with Cell-loading Capability and Chondrogenic Inducibility for Tissue-Engineered Fibrocartilage and Bone-Tendon Healing.ACS Appl Mater Interfaces

›81.Three-dimensional characterization of the microstructure in rabbit patella-patellar tendon interface using propagation phase-contrast synchrotron radiation microtomography.J Synchrotron Radiat

›82.The protective effect of microRNA-21 in neurons after spinal cord injury.Spinal Cord

›83.SR-FTIR as a tool for quantitative mapping of the content and distribution of extracellular matrix in decellularized book-shape bioscaffolds.BMC Musculoskelet Disord

›84.Tendon Healing in Bone Tunnel after Human Anterior Cruciate Ligament Reconstruction: A Systematic Review of Histological Results.J Knee Surg

›85.Low-Intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing: A Dose-Dependent Study.Am J Phys Med Rehabil

›86.Morphometric Analysis of Rat Spinal Cord Angioarchitecture by Phase Contrast Radiography: From 2D to 3D Visualization.Spine (Phila Pa 1976)

›87.Genetic factors of cervical spondylotic myelopathy-a systemic review.J Clin Neurosci

›88.Tetramethylpyrazine Facilitates Functional Recovery after Spinal Cord Injury by Inhibiting MMP2, MMP9, and Vascular Endothelial Cell Apoptosis.Curr Neurovasc Res

›89.Nondestructive imaging of the internal microstructure of vessels and nerve fibers in rat spinal cord using phase-contrast synchrotron radiation microtomography.J Synchrotron Radiat

›90.Comparison of Synchrotron Radiation-based Propagation Phase Contrast Imaging and Conventional Micro-computed Tomography for Assessing Intervertebral Discs and Endplates in a Murine Model.Spine (Phila Pa 1976)

›91.Histological observation of a gelatin sponge transplant loaded with bone marrow-derived mesenchymal stem cells combined with platelet-rich plasma in repairing an annulus defect.PLoS One

›92.Feasibility study for evaluating early lumbar facet joint degeneration using axial T1 ρ, T2 , and T2* mapping in cartilage.J Magn Reson Imaging

›93.Synchrotron radiation micro-CT as a novel tool to evaluate the effect of agomir-210 in a rat spinal cord injury model.Brain Res

›94.Three Dimensional Quantification of Microarchitecture and Vessel Regeneration by Synchrotron Radiation Microcomputed Tomography in a Rat Model of Spinal Cord Injury.J Neurotrauma

›95.Tetramethylpyrazine enhances functional recovery after contusion spinal cord injury by modulation of MicroRNA-21, FasL, PDCD4 and PTEN expression.Brain Res

›96.Visualization of mouse spinal cord intramedullary arteries using phase- and attenuation-contrast tomographic imaging.J Synchrotron Radiat

›97.Initiation Timing of Low-Intensity Pulsed Ultrasound Stimulation for Tendon-Bone Healing in a Rabbit Model.Am J Sports Med

›98.C-C motif chemokine ligand 20 regulates neuroinflammation following spinal cord injury via Th17 cell recruitment.J Neuroinflammation

›99.Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats.Neuroscience

›100.Micro-CT as a Tool to Investigate the Efficacy of Tetramethylpyrazine in a Rat Spinal Cord Injury Model.Spine (Phila Pa 1976)

›自动电控重力式急性脊髓损伤动物模型建模打击器

›三相组织工程支架

›一种组织工程人工骨及其构建方法

›一种缓释抗菌复合植骨材料及其制备方法

›三相支架

›急性脊髓损伤动物模型建模打击器

›一种具有纳米羟基磷灰石涂层的多孔双相磷酸钙生物支架及其制备

›双相组织工程支架

›踝关节自动加压活动调节仪

›一种脊髓损伤动物模型打击器

›一种小动物椎板剥离器

›一种组织工程支架的脱细胞方法

›区域干细胞诱导活性去细胞骨腱界面书页支架

›用于分区骨腱界面支架的分隔装置及其分隔方法

›一种双重仿生骨腱界面书页支架

›一种双相组织工程支架

›一种组织工程支架矿化装置和方法

›一种转基因小鼠繁育方法

›三相仿生套筒支架及制备方法

›一种细胞外基质高保留的脱细胞半月板及其制备方法

›一种坐位体前屈的测试装置

›一种外泌体水凝胶混合体系及其制备方法

›含CD56+亚细胞群来源外泌体的生物材料及其制备方法

›一种组织工程人工骨及其构建方法, 申请号:ZL201310440363. 2

›自动电控重力式急性脊髓损伤动物模型建模打击器, 申请号:ZL 2011 1 0240648.2

›一种具有纳米羟基磷灰石涂层的多孔双相磷酸钙生物支架及其制备, 申请号:ZL 2010 1 0580428.X

›急性脊髓损伤动物模型建模打击器, 授权号:ZL 2010 1 0125269.4.

›

›

›《运动损伤常用运动处方》主编

›《关节软骨分子生物学及研究》 主编.吕红斌,湖南科学技术出版社,2015

›《美国骨科医师教程——髋关节》参译,人民军医出版社,2009

›《骨内科学》编委.吕红斌,人民卫生出版社,2013

›湖南省科学技术进步奖|2001

›Excellence in Basic Science Award|2017

›2016长沙国际马拉松赛先进个人|2016

›湖南省自然科学奖|2017

›华夏医学科学奖|2017

›十佳教师|2018

›十佳科技工作者|2018

›优秀科研工作者|2018

›国家运动医学重点专科学科带头人|2013

›湖南省省级重点学科运动医学学科带头人,吕红斌

›湖南省普通高等学校学科带头人培养对象（运动医学专业）,吕红斌

›中南大学“升华学者计划”特聘教授|2009,吕红斌

›Tendon and Ligament：Biology& Development|2012

›《The Size and the Mineralization of Newly Formed Bone Predict the Quality of Bone-Tendon Junction Repair – A PartiaPatellectomy Model in Rabbits》|2010

›The Combined Magnetic Fields Accelerates Bone-Tendon Junction Injury Healing through Osteogenesis: two-dimensional and three-dimensional orientations.|2013

›《Three-dimensional Micro-structural and Micro-morphologic Analyses of the Microvasculature of the Spinal Cord after Acute Injury in a Rat Model using MicroCT Method》|2011

›Lu HB, Qin L, Ho NM, et. al. Low Intensity Pulsed Ultrasound Accelerates Bone -Tendon Junction Repair. Best Paper Award: ICHTS – CSOS Workshop at The 4th CSOS Scientific Congress on September 24 – 26, 2004 , Beijing, China

›《A novel method to visualize the 3D alterations of microvasculature in a rat spinal cord injury model: a study with synchrotron radiation micro-angiography.》|2013

›《Tetramethylpyrazine Attenuates Apoptosis through Modulating microRNA-21 after Contusion spinal cord injury in Rats.》|2013

›《High-resolution 3D imaging of rat spinal vascular structure: a novel method by synchrotron radiation-based micro-CT》|2012

›当归、丹参、黄芪、川芎嗪对损伤关节软骨修复机理的研究|1995

›Bone-Tendon healing enhancement using Combined Magnetic Fields in a rabbit patella-patellar injury model.|2013

›活血化瘀中药对损伤的关节软骨的修复|1995

›《Three-dimensional Micro-structural and Micro-morphologic Analyses of the Microvasculature of the Spinal Cord after Acute Injury in a Rat Model using MicroCT and Graphic Reconstruction Techniques》|2010

›《Three-dimensional Visualization of Microvasculature of Rat Spinal Cord in vitro by Synchrotron Radiation Micro-angiography.》|2013

›《Three-dimensional Micro-structural and Micro-morphologic Analyses of the Microvasculature of the Spinal Cord after Acute Injury in a Rat Model using MicroCT Method”》|2011

›《Anti-Apoptosis Effect of microRNA-21 in Control of Cell Death after Contusion Spinal Cord Injury in Rats.》|2013

›从分子水平探讨骨关节病的发病机理及中药对关节软骨细胞的影响|2001,吕红斌

›《Healing and Remodeling of Connective Tissues under Biophysical Stimulation in a Rabbit Patella - Patella Tendon Junction Model》|2010

›《High-resolution 3D imaging of rat spinal vascular structure: a novel method by synchrotron radiation-based micro-CT.》|2013