Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes
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发表刊物:
e
刊物所在地:
urope
关键字:
Leptin TNF-α Genetic polymorphism Rosiglitazone Type 2 diabetes
摘要:
Abstract
BACKGROUND:
Leptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM). The aims of the present study were to investigate the association between leptin G-2548A and TNF-alpha G-308A polymorphisms and rosiglitazone response in T2DM patients.
MATERIALS:
245 patients with T2D and 122 health volunteers were enrolled to identify leptin G-2548A and TNF-alpha G-308A genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Forty-two T2D patients with……
合写作者:
Liu ZQ., Zhou HH, Wang D, Zhang W, Yin JY, Hu PC, Gong ZC, Sun H, Wu J, Lin YG, Liu HL1
论文类型:
基础研究
论文编号:
doi: 10.1007/s00228-008-0483-9
学科门类:
临床医学
文献类型:
J
卷号:
64
期号:
7
页面范围:
663-71.
ISSN号:
doi: 10.1007/s00228-008-0483-9
是否译文:
否
附件: