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向皞月，硕士生导师，毕业于中科院上海药物研究所，在杂环化合物库的构建、苗子/先导化合物的发现取得了一定进展。构建了基于色酮的含氮杂环小分子化合物库，并从中发现了一些结构新颖的抗肿瘤先导化合物；设计合成了系列PI3K抑制剂，在体外表现出了良好的抗肿瘤活性。2015年加入中南大学以来，致力于光氧化还原催化体系研究以及含氮/氟杂环小分子化合物库构建新方法的开发。2021年受KC Wong奖学金资助，赴英国King's College London和University College London进行酶催化领域博士后研究工作。主持国家自然科学基金、湖南省优青、中国博士后科学基金面上项目等课题5项，以第一或通讯作者在Angew. Chem. Int. Ed.，ACS Catal., Org. Lett., J. Org. Chem., Eur J Med Chem., Bioorg. Med. Chem. Lett.,等国际权威期刊发表SCI论文60余篇，参与撰写学术专著2部，申请PCT专利1项（已在美国、欧盟、日本等国授权），授权中国专利2项。

科研项目：

1. 2022-2024 基于可见光-有机催化绿色合成方法学研究 湖南省自然科学基金委 优青项目

2. 2020-2023 可见光促进的含氟杂环化合物库集群式构建研究 湖南省自然科学基金委 面上项目
3. 2018～2020 基于优势骨架的片螺素类似物的设计/优化及抗肿瘤活性研究 国家自然科学基金委 青年基金
4. 2017～2018 选择性靶向PI3K的共价键抑制剂/酶降解剂的 新药研究国家重点实验室 
5. 2017～2018 芳基取代吡咯并三嗪类化合物的抗肿瘤活性研究 中国博士后基金会 
6. 2017～2019 新型呫吨酮衍生物的设计合成及抗肿瘤活性研究 湖南省自然科学基金委 青年基金

代表性学术论文：（ORCID, 0000-0002-7404-4247)

2020

1. Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives. Bioorganic & Medicinal Chemistry Letters 2020, 30, 127194.

2. Photoinduced Single-Electron-Transfer Process as an Enabling Principle in Radical Borylation of Alkenes with NHC-borane Angewandte Chemie International Edition 2020, 59, 6706-6710.

3. Photocatalytic C-F Bond Borylation of Polyfluoroarenes with NHC-boranes.Organic Letters 2020, 22, 1742-1747. 

4. Phosphine-Mediated MBH-Type/Umpolung Addition Domino Sequence: Divergent Construction of Coumarins. Organic Letters 2020, 22, 488-492.

5. Visible-Light-Induced, Catalyst-Free Radical Cross-Coupling Cyclization of N-Allylbromodifluoroacetamides with Disulfides or Diselenides. Journal of Organic Chemistry 2020, 85, 5670-5682.

6. O-Perfluoropyridin-4-yl Oximes: Iminyl Radical Precursors for Photo- or Thermal-Induced N-O Cleavage in C(sp(2)) C(sp(3)) Bond Formation. Journal of Organic Chemistry 2020, 85, 3538-3547.

2019

1. Visible-Light-Driven, Photoredox-Catalyzed Cascade of ortho-Hydroxycinnamic Esters To Access 3-Fluoroalkylated Coumarins. Journal of Organic Chemistry 2019, 84, 7480-7487.

2.  Photocatalytic, Phosphoranyl Radical-Mediated N-O Cleavage of Strained Cycloketone Oximes. Organic Letters 2019, 21, 2658-2662. （ESI高被引）

3. Organocatalytic, Enantioselective, Polarity-Matched Ring-Reorganization Domino Sequence Based on the 3-Oxindole Scaffold. Organic Letters 2019, 21, 2166-2170.

4.  A One-Pot Ring-Opening/Ring-Closure Sequence for the Synthesis of Polycyclic Spirooxindoles. Chemistry-A European Journal 2019, 25, 4673-4677.

5. Photocatalytic reductive radical-radical coupling of N,N '-cyclicazomethine imines with difluorobromo derivatives. Chemical Communications 2019, 55, 2712-2715.

   
   

2018

1. Visible-Light-Induced External Radical-Triggered Annulation To Access CF2-Containing Benzoxepine Derivatives. Organic Letters 2018, 20, 1363-1366.

2. Solvent-Minimized, Chromatography-Free, Diastereoselective Synthesis of Oxazolidine-Dispirooxindoles via oxa-1,3-Dipolar Cycloaddition of 3-Oxindole. Journal of Organic Chemistry 2018, 83, 2948-2953.

3.  Photoredox-catalyzed direct aminoalkylation of isatins: diastereoselective access to 3-hydroxy-3-aminoalkylindolin-2-ones analogues. Organic Chemistry Frontiers 2018, 5, 1608-1612.

4. Visible-Light-Promoted Synthesis of 1,4-Dicarbonyl Compounds via Conjugate Addition of Aroyl Chlorides. Chemistry-an Asian Journal 2018, 13, 271-274.

5. Organocatalytic Domino Entry to an Octahydroacridine Scaffold Bearing Three Contiguous Stereocenters. Journal of Organic Chemistry 2018, 83, 12284-12290.

6. Unraveling and Manipulating the Stereospecific Retro-Aldol Reaction in the Organocatalytic Asymmetric Aldol Reaction of Isatin and Cyclohexanone. Organic Letters 2018, 20, 7535-7538.

7. 7-Site Substituted Pyrrole Triazine Compounds or Pharmaceutically Acceptable Salts Thereof, and Preparation Method Therefor and Uses Thereof. 2018, WO20182333684 (A1).

   
   

2017-

1. Selectfluor-Triggered Tandem Cyclization of o-Hydroxyarylenaminones To Access Difluorinated 2-Amino-Substituted Chromanones. Journal of Organic Chemistry 2017, 82, 9837-9843.

2. Visible-Light-Driven, Radical-Triggered Tandem Cyclization of o-Hydroxyaryl Enaminones: Facile Access to 3-CF2 /CF3-Containing Chromones. Organic Letters  2017, 19, 146-149.（Nature Index）

3. Photoredox-Catalyzed Reductive Dimerization of Isatins and Isatin-Derived Ketimines: Diastereoselective Construction of 3,3′-Disubstituted Bisoxindoles. Journal of Organic Chemistry 2017, 82, 3895-3900.

4. Diastereoselective Intramolecular [3 + 2]-Annulation of Donor–Acceptor Cyclopropane with Imine-Assembling Hexahydropyrrolo[3,2-c]quinolinone Scaffolds. Journal of Organic Chemistry 2016, 81, 11185-11194.

5. A Facile and General Approach to 3-((Trifluoromethyl)thio)-4H-chromen-4-one. Organic Letters  2014, 16, 5686-5689.（Nature Index）