Assessment of PET/CT in multifocal myeloid sarcomas with loss of TET2: a case report and literature review

Release time:2020-07-12

Impact Factor:0.205

Affiliation of Author(s):中南大学

Teaching and Research Group:病理学系

Journal:Int J Clin Exp Pathol

Key Words:Myeloid sarcoma, PET-CT, TET2, 5hmC, MPO, CD117

Abstract:Myeloid sarcoma is a rare solid tumor consisting of leukemic myeloblasts and/or myeloid precursors occurring outside the blood or bone marrow. The unique site with myeloid sarcoma has been reported, the multiple sites of myeloid sarcoma have rarely been cited in the medical literature. Here we report that the unusual clinical presentation and management of myeloid sarcoma in multiple sites with PET-CT, highlighting the utility of PET-CT was useful in detecting and monitoring myeloid sarcoma. We also found that loss of TET2 and gain of 5hmC in the case of myeloid sarcoma, indicating the mechanism for myeloid sarcoma is totally different with other hematopoietic malignancies.

Co-author:Yongguang Tao, Chunyan Fu, Jiantao Jia, Shuang Liu

First Author:Yu Pan

Indexed by:Journal paper

Correspondence Author:Desheng Xiao

Volume:8(10)

Page Number:13630-4

Translation or Not:no

Date of Publication:2015-10-01

Included Journals:SCI