Supervisor of Master's Candidates
School/Department:Pharmaceutical Sciences
Administrative Position:副教授
Education Level:With Certificate of Graduation for Doctorate Study
Sex:Male
Contact Information:nulixie@csu.edu.cn
Degree:Doctoral degree
Status:Employed
Alma Mater:湖南大学
Discipline:Chemistry
Pharmaceutical Science
谢努力，副教授，硕士研究生导师。博士毕业于湖南大学，上海交通大学博士后（博后导师：樊春海院士）。博士期间获得国家奖学金、校长奖学金等荣誉，曾获国家留学基金委（CSC）公派奖学金资助，赴University of Michigan安娜堡分校以联合培养博士研究生的身份交流学习2年。博士后期间获得上海市”超级博士后“激励计划资助。现为中国化学会会员，湖南省生物医学工程学会纳米医学与工程专委委员，《Exploration》期刊青年编委。主要从事核酸纳米技术在分子计算、疾病诊断、新型药物递送和疾病治疗等领域研究，以第一作者/通讯作者在JACS、Angew. Chem. Int. Ed.、ACS Nano、Adv. Sci.、Nano lett.、Chem. Sci.、Anal. Chem.、Chem. Commun.等国际知名期刊发表论文十余篇，并以第二作者身份参与《Nature》的发表。 论文总引次数达 2400次以上，H-index为23。
主持国家自然科学基金青年项目 、湖南省自然科学基金青年项目 ，国家重点实验室开放基金 ，中南大学科研启动项目等科研项目。参与国家自然科学基金重点项目、面上项目多项。
ORCID: https://orcid.org/0000-0002-8846-0532
研生招生：
热忱欢迎具有药学、化学、化学生物学等学科背景的研究生或本科生加入研究团队。
研究方向及兴趣：
1、基于DNA自组装纳米结构的智能药物递送
2、DNA分子计算在癌症和其他疾病上的智能、精准诊断应用
3、核酸与金属相结合的纳米材料制备及其皮肤相关疾病的治疗
本科教学与毕业指导：
2024年，中南大学教学质量优秀奖（本科）
2024年，指导学生获得湖南省省级大学生创新训练项目1项
代表性论文与成果：
Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie*, Wenhu Zhou*, Shuang Zhao*. Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy. Advanced Science, 2025, 12, 19, 2415296.
Shiyuan Liu, Jiaoli Wang, Yu Chen, Jiahao Fan, Bin Du, Ruiting Liu, Xiaobei Zhu, Kemin Wang, Nuli Xie*, Jin Huang*. Modular Assembled Localized Hybridization Chain Reaction for In Situ mRNA Amplified Imaging [J]. Nano. Lett., 2024, 24, 37, 11590–11598.
Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*. CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition. Adv. Funct. Matter. 2024, DOI:10.1002/adfm.202403469.
Hui Lv, Nuli Xie, Mingqiang Li, Mingkai Dong, Jiang Li, Xiaolei Zuo, Haibo Chen, Fei Wang*, Chunhai Fan*. DNA-based programmable gate arrays for general-purpose DNA computing. Nature 2023, 622, 292-300.
Xiangcheng Zhao, Nuli Xie, Hailong Zhang, Wenhu Zhou*, Jinsong Ding*. Bacterial Drug Delivery Systems for Cancer Therapy: "Why" and "How". Pharmaceutics 2023, 15(9), 2214.
Zhenxiang Liu#, Nuli Xie#, Juan Li, Xiaoxiao Fu, Kemin Wang, Hui Shi*, Jin Huang*. Self-Priming DNA Polymerization-Propelled Stochastic Walkers on Magnetic Microbeads for Amplified Detection of miRNA. Anal. Chem. 2023, 95, 4529-4535.
Yuanfeng Han#, Nuli Xie#, Wenhu Zhou*. Copper Coordination-Based Nanomedicine for Tumor Theranostics. Advanced Therapeutics 2023, 7, 2300305.
Nuli Xie, Mingqiang Li, Yue Wang, Hui Lv, Jiye Shi, Jiang Li, Qian Li, Fei Wang*, Chunhai Fan. Scaling up multi-bit DNA full adder circuits with minimal strand displacement reactions. J. Am. Chem. Soc. 2022, 144, 9479-9488.
Nuli Xie, Shiyuan Liu, Hongmei Fang, Yanjing Yang, Ke Quan, Jing Li, Xiaohai Yang, Kemin Wang, Jin Huang*. Three-dimensional molecular transfer from DNA nanocages to inner gold nanoparticle surfaces. ACS Nano 2019, 13, 4174-4182.
Nuli Xie, Haiyan Wang, Ke Quan, Feng Feng, Jin Huang*, Kemin Wang*. TrAC-Trends in Anal. Chem. 2020, 126, 115844.
Nuli Xie, Huimin Wang, Xiaoxiao Fu, Jiaoli Wang, Jing Li, Kemin Wang, Jin Huang*. Dual amplification of bio-barcode and auto-cycling primer extension for highly sensitive detection of miRNA. Chem. Commun. 2022, 58, 10221-10224.
Nuli Xie, Jin Huang*, Xiaohai Yang, Xiaoxiao He, Jianbo Liu, Jiaqi Huang, Hongmei Fang, Kemin Wang*. Scallop-inspired DNA nanomachine: a ratiometric nanothermometer for intracellular temperature sensing. Anal. Chem. 2017, 89, 12115-12122.
Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Min Ou, Hongmei Fang, Kemin Wang*. Competition-mediated FRET-switching DNA tetrahedron molecular beacon for intracellular molecular detection. ACS Sens. 2016, 12, 1445-1452.
Nuli Xie, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, He Wang, Le Ying, Min Ou, Kemin Wang*. A DNA tetrahedron-based molecular beacon for tumor-related mRNA detection in living cells. Chem. Commun. 2016, 52, 2346-2349.
Nuli Xie, Shiyuan Liu, Xiaohai Yang, Xiaoxiao He, Jin Huang*, Kemin Wang*. DNA tetrahedron nanostructures for biological applications: biosensors and drug delivery. Analyst 2017, 142, 3322-3332.
Le Ying #, Nuli Xie#, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang*, Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chem. Commun. 2016, 52, 7818-7821.
Hongmei Fang#, Nuli Xie#, Min Ou, Jin Huang, Wenshan Li, Qing Wang, Jianbo Liu, Xiaohai Yang*, Kemin Wang*. Detection of nucleic acids in complex samples via magnetic microbead-assisted catalyzed hairpin assembly and “DD-A” FRET. Anal. Chem. 2018, 90, 7164-7170.
Jing Li, Jiaoli Wang, Shiyuan Liu, Nuli Xie, Ke Quan, Yanjing Yang, Xiaohai Yang, Jin Huang*, Kemin Wang*. Amplified FRET nanoflares: an endogenous mRNA‐powered nanomachine for intracellular microRNA imaging. Angew. Chem. Int. Ed. 2020, 132, 20104-20111.
Jesús Mosquera, Yuan Zhao, Hee‐Jeong Jang, Nuli Xie, Chuanlai Xu, Nicholas A. Kotov, Luis M. Liz‐Marzán*. Plamnonic nanoparticles with supramolecular recognition. Adv. Funct. Mater. 2019, 1902082.
Yanjing Yang, Jin Huang, Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, Kemin Wang*. FRET nanoflares for intracellular mRNA detection: avoiding false positive signals and minimizing effects of system fluctuations. J. Am. Chem. Soc. 2015, 137, 8340-8343.
Ke Quan, Jing Li, Jiaoli Wang, Nuli Xie, Qiaomei Wei, Jinlu Tang, Xiaohai Yang, Kemin Wang, Jin Huang*. Dual-microRNA-controlled double-amplified cascaded logic DNA circuits for accurate discrimination of cell subtypes. Chem. Sci. 2019, 10, 1442-1449.
Yanjing Yang, Jin Huang, Xiaohai Yang, Xiaoxiao He, Ke Quan, Nuli Xie, Min Ou, Kemin Wang*. Gold Nanoparticle Based Hairpin-Locked-DNAzyme Probe for Amplified miRNA Imaging in Living Cells. Anal. Chem. 2017, 89, 5850-5856.
Yanan Wu, Jin Huang*, Xiaohai Yang, Yanjing Yang, Ke Quan, Nuli Xie, Jing Li, Changbei Ma, Kemin Wang*. Gold Nanoparticle Loaded Split-DNAzyme Probe for Amplified miRNA Detection in Living Cells. Anal. Chem. 2017, 89, 8377-8383.
