个人简介
杨力芳,病理学与病理生理学博士,临床肿瘤学博士后,研究员，博士生导师。教育部癌变与侵袭原理重点实验室PI。中国抗癌协会肿瘤标志专委会鼻咽癌专委会委员，湖南省病理生理学会肿瘤专业委员会常委，湖南省生物信息学会理事。研究方向为肿瘤发生发展，转移及治疗抵抗的分子机制，目前重点研究肿瘤微环境和蛋白质翻译后修饰在肿瘤恶性进展中的分子作用机制。近年来在Molecular Therapy, J Exp Clin Cancer Res, Oncogene和Cancer Letters等国际期刊发表SCI学术论文50多篇。先后主持国家自然科学基金七项，湖南省自然科学基金等省部级基金项目九项，作为主要成员承担“四大慢病”国家科技重大专项，国家创制新药重大专项、国家863计划、国家支撑计划、国家自然科学基金重点项目等多项。获国家发明专利3项。获湖南省自然科学优秀学术论文一等奖，教育部高等学校科学研究优秀成果奖(自然科学奖)二等奖。指导毕业硕、博士研究生19人，目前指导博士研究生4名，硕士研究生3名，指导研究生获研究生科研创新项目多项及国家奖学金等学术奖励。
目前主持的国家级项目：
1.国家自然科学基金面上项目：DLST琥珀酰化介导的线粒体代谢重塑和铜死亡抵抗促进肺腺癌的恶性进展，项目批准号：82573929，2026-01-01至2029-12-31。
2.国家自然科学基金面上项目：TALDO1的去乙酰化修饰重塑糖代谢促进鼻咽癌的恶性进展，项目批准号：82372683, 2024-01-01至2027-12-31。
近年来发表的主要文章：
1. Xingzhi Peng, Peijun Zhou, Kun Zhang, Likang Chen, Min Tang, Qin Zhou, Jinwu Peng, Lifang Yang*. Deacetylation-mediated TADLO1 remodels glucose metabolism through a moonlighting function to promote nasopharyngeal carcinoma malignant progression. Cell Death Dis. 2025 https://doi.org/10.1038/s41419-025-08057-2.
2. Tang S, Qu C, Zhang M, Zhou P, Peng X, Zhou Z, Shen L*, Yang L*. Novel mutations of SRPX facilitate the stemness and malignant progression of glioma. Br J Cancer. 2025 Oct;133(6):784-794.
3. Zhang K, Peng X, Zhou P, Li X, Shen L, Yang L*, Zhou Q*.HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH147. Oncogene. 2025 Sep;44(35):3183-3198.
4. Zhou P, Peng X, Zhang K, Cheng J, Tang M, Shen L, Zhou Q, Li D*, Yang L*. HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma. Cell Death Dis. 2025 Mar 6;16(1):160
5. Hu X, Zhou P, Peng X, Ouyang Y, Li D, Wu X*, Yang L*. PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A. Journal of Translational Medicine. 2024 Nov 20;22(1):1047.
6. Zhou Z, Qu C, Zhou P, Zhou Q, Li D, Wu X*, Yang L*. Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer. J Exp Clin Cancer Res. 2024 Jun 3;43(1):158.
7. Gong D, Rao X, Min Z, Liu X, Xin H, Zhou P, Yang L*, Li D*. UBE2S targets RPL26 for ubiquitination and degradation to promote non-small cell lung cancer progression via regulating c-Myc. Am J Cancer Res. 2023 Aug 15;13(8):3705-3720.
8.Sun X, Zhang K, Peng X, Zhou P, Qu C, Yang L*, Shen L*. HDAC4 mediated LHPP deacetylation enhances its destabilization and promotes the proliferation and metastasis of nasopharyngeal carcinoma. Cancer Lett. 2023 May 28; 562:216158.
9. Cheng J, Zhang K, Qu C, Peng J*, Yang L*. Non-Coding RNAs Derived from Extracellular Vesicles Promote Pre-Metastatic Niche Formation and Tumor Distant Metastasis. Cancers (Basel). 2023 Apr 5;15(7):2158.
10. Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J*, Yang L*. E3 ligase MAEA-medicated ubiquitination and degradation of PHD3 promotes glioblastoma progression. Oncogene. 2023 Apr;42(16):1308-1320.
11. Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J*, Yang L*. UBE2T promotes glioblastoma malignanacy through ubiquitination-mediated degradation of RPL6. Cancer Sci. 2023 Feb;114(2):521-532.
12. Yu X, Zhou Z, Tang S, Zhang K, Peng X, Zhou P, Zhang M, Shen L*, Yang L*. MDK induces temozolomide resistance in glioblastoma by promoting cancer stem-like properties. Am J Cancer Res. 2022, Oct 15; 12(10): 4825-4839.
13.Shan Y, Zhou P, Zhou Q, Yang L*.Extracellular Vesicles in the Progression and Therapeutic Resistance of Nasopharyngeal Carcinoma. Cancers (Basel). 2022, May 4;14(9):2289.
14. Xu S, Zhou Z, Peng X, Tao X, Zhou P, Zhang K, Peng J, Li D, Shen L, Yang L*. EBV-LMP1 Promotes 1 Radioresistance by Inducing Protective Autophagy through BNIP3 in Nasopharyngeal Carcinoma. Cell Death Dis. 2021, Apr 1; 12(4): 344.
15. Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D*, Yang L*. LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance. Am J Cancer Res. 2020 Jul 1;10(7):2083-2099.
16. Wu X, Zhou Z, Xu S, Liao C, Chen X, Li B, PengJ , Li D*, Yang L*. Extracellular vesicle packaged LMP1-activated fibroblasts promote tumor progression via autophagy and stroma-tumor metabolism coupling. Cancer Lett. 2020 May 28; 478:93-106.
17. Liao C, Zhou Q, Zhang Z, Wu X, Zhou Z, Li B, Peng J, Shen L, Li D, Luo X, Yang L*. Epstein-Barr virus-encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan-2 and synaptotagmin-like-4 in nasopharyngeal carcinoma cells. Cancer Sci. 2020 Mar;111(3):857-868.
18. Zhou Z, Zhou Q, Wu X,Xu S,Hu X,Tao X,Li B,Peng J, Li D, Shen L, Cao Y, Yang L*.VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling. Cancer Lett. 2020 Mar 31; 473:62-73.
19. Zhang Z, Yu X, Zhou Z, Li B, Peng J, Wu X, Luo X*, Yang L*.LMP1-positive extracellular vesicles promote radioresistance in nasopharyngeal carcinoma cells through P38 MAPK signaling. Cancer Med. 2019 Oct;8(13):6082-6094.