Associate Professor
Supervisor of Master's Candidates
Date of Employment:2017-09-20
School/Department:Chemistry and Chemical Engineering
Education Level:PhD Graduate
Sex:Female
Degree:Doctoral degree
Status:Employed
Alma Mater:湖南大学
Discipline:Chemistry
杨艳婧，女，博士，博士生导师，主要从事“纳米尺度上的生物分析化学”、“纳米药物递送”等研究工作。在基因检测、DNA机器、信号放大、分子探针设计、细胞原位分析、疾病早期诊断及纳米药物抗肿瘤研究等方面取得了一系列研究成果。 迄今为止，在 JACS、Angew. Chem. Int. Ed.、ACS Nano、Chem. Sci.、Anal. Chem.、Chem. Commun.等杂志上发表论文50余篇，其中高被引论文1篇，IF＞6分论文20篇，JCR一区论文40篇，应邀撰写综述2篇， 论文总他引次数 1181次，单篇最高他引 226 次，H-index 达17。曾获得湖南省优秀博士学位论文奖，国家奖学金，校长奖学金，并先后主持国家自然科学基金，湖南省自然科学基金等项目。
科研成果：
1.教学科研项目：
国家自然科学基金面上项目，遗传编码的荧光RNA适配体探针用于脑活性分子成像研究，54万，主持；
国家自然科学青年基金，基于多功能DNA纳米探针的癌症治疗与疗效原位评估研究，24万，主持；
湖南省自然科学基金，基于碳量子点和DNA的比率型探针在细胞表面的应用研究，5万，主持；
中央高校基本科研业务专项基金，特聘副教授，80万，主持；
化学生物传感与计量学国家重点实验室（湖南大学）开放课题，3万，主持。
中南大学教学改革项目，基于OBE理念协同培养创新性人才的《药用高分子材料》教学改革研究，2万，主持。
广西壮族自治区科技厅广西科技基地和人才专项，165万，在研，参与。
国家自然科学基金面上项目，抗原蛋白-分子印迹荧光可视化载体体系的精准构筑及其分离机制研究，54万，参与。
2. 获得奖励
湖南省优秀博士学位论文奖；
中南大学第十一届“三十佳”课堂教学竞赛“三十佳”荣誉称号。
3. 代表性论文：
(1) Yanjing Yang; Tong Luo; Yao He；Zhiwei Deng；Jiacheng Li; Hui Liu; Jing Nie; De Wang; Jin Huang*; Shian Zhong*; Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy，Analytical Chemistry，2022, 94(35): 12204-12212.
(2) Tong Luo; Jiacheng Li; Yao He; Hui Liu; Zhiwei Deng; Xi Long; Qingqing Wan; Jiacheng Ding; Zan Gong; Yanjing Yang*; Shian Zhong*; Designing a CRISPR/Cas12a- and Au-Nanobeacon-Based Diagnostic Biosensor Enabling Direct, Rapid, and Sensitive miRNA Detection, Analytical Chemistry， 2022, 94(17): 6566–6573.
(3) Zhiwei Deng; Jiacheng Li; Hui Liu; Tong Luo; Yanjing Yang*; Minghui Yang*; Xiang Chen*; A light-controlled DNA nanothermometer for temperature sensing in the cellular membrane microenvironment, Biosensors and Bioelectronics, 2022: 114627.
(4) Jiacheng Li; Tong Luo; Yao He; Hui Liu; Zhiwei Deng; Jiaqi Bu; Xi Long; Shian Zhong*; Yanjing Yang*; Discovery of the Rnase activity of CRISPR–Cas12a and its distinguishing cleavage efficiency on various substrates, Chemical Communications , 2022, 58: 2540-2543.
(5) Tianhao Li; Zhiwei Deng; Jiaqi Bu; Hui Liu; Yanjing Yang*; Shian Zhong*; Quantum dot based molecularly imprinted polymer test strips for fluorescence detection of ferritin, Sensors and Actuators: B. Chemical , 2022, 358:131548.
(6) Zhiwei Deng; Peiru Gao; Hui Liu; Yao He; Shian Zhong; Yanjing Yang*; Cell-Surface-Anchored DNA Sensors for Simultaneously Monitoring Extracellular Sodium and Potassium Levels, Analytical Chemistry , 2021, 93(49): 16432-16438.
(7) Yanjing Yang; Yao He; Zhiwei Deng; Jiacheng, Li; Jin Huang; Shian Zhong*. Intelligent Nanoprobe: Acid-Responsive Drug Release and In Situ Evaluation of Its Own Therapeutic Effect. Analytical chemistry, 2020, 92, 12371-12378.
(8) Deng, Zhiwei; Li, Xiufang; Liu, Hui; He, Yao; Zhang, Jie; Yuan, Jing; Gao, Peiru; Jiang, Xuling; Yang, Yanjing;* Zhong, Shian.* A nanoprobe for ratiometric imaging of glutathione in living cells based on the use of a nanocomposite prepared from dual-emission carbon dots and manganese dioxide nanosheets. Microchimica Acta. 2020, 187, 537.
(9) Yuan, Jing; Deng, Zhiwei; Liu, Hui; Li, Xiufang; Li, Jianbing; He, Yao; Qing, Zhihe; Yanjing Yang;* Zhong, Shian.* Cell-Surface-Anchored Ratiometric DNA Nanoswitch for Extracellular ATP Imaging. ACS SENSORS. 2019, 4, 1648-1653.
(10) Yanjing Yang, Jin Huang,* Xiaohai Yang, Xiaoxiao He, Ke Quan, Nuli Xie, Min Ou, Kemin Wang.* Gold nanoparticle based hairpin-locked-DNAzyme probe for amplified miRNA imaging in living cells. Analytical chemistry, 2017, 89, 5850−5856.
(11) Yanjing Yang, Jin Huang,* Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, and Kemin Wang*. An aptazyme-gold nanoparticle sensor for amplified molecular probing in living Cells. Analytical chemistry, 2016, 88, 5981-5987.
(12) Yanjing Yang, Jin Huang,* Xiaohai Yang, Ke Quan, Nuli Xie, Min Ou, Jinlu Tang and Kemin Wang*. Aptamer-based FRET nanoflares for imaging potassium ions in living cells. Chemical Communications, 2016, 52, 11386-11389.
(13) Le Ying, Nuli Xie, Yanjing Yang,* Xiaohai Yang, Qifeng Zhou, Bincheng Yin, Jin Huang,* and Kemin Wang*. A cell-surface-anchored ratiometric i-motif sensor for extracellular pH detection. Chemical Communications, 2016, 52, 7818-7821.
(14) Yanjing Yang, Jin Huang, Xiaohai Yang, Ke Quan, He Wang, Le Ying, Nuli Xie, Min Ou, and Kemin Wang*. FRET nanoflares for intracellular mRNA detection: avoiding false positive signals and minimizing effects of system fluctuations. Journal of the American Chemical Society, 2015, 137, 8340-8343.
