Personal Information

Gang Yin, Ph.D.
Professor/Vice Dean: School of Basic Medicine, Central South University

172 TongZiPo Rd. Bldg of Pathology Rm210, Changsha, Hunan, China 410013 Phone: 86-731-82650413; Email: gang.yin@csu.edu.cn

Education:
2006 Ph.D. in Molecular Genetics, Fudan University, Shanghai, China 2000 B.S. in Biology, Inner Mongolia University, Huhhot, China

Research Experience:
Ø 12/13~present Professor/Vice Dean School of Basic Medicine,

Central South University
Ø 7/12~11/13 Professor Dept. of Pathology, School of

Basic Medicine, Central South University.

Research Projects:

1. Study the molecular mechanisms of cancer stem cell differentiation and metastasis
2. Study the functions of exosome in cancer cell properties such as EMT, metastasis, chemoresistance and immune response in normoxia or hypoxia.

Ø 11/10~7/12 Associate Research Scientist.OBGYN, School of Medicine, Yale Univ. New Haven, CT, USA

Research projects:

1) Study the molecular mechanisms of Twist1 in regulating ovarian cancer stem cell differentiation and metastasis

2) StudythemechanismofmicroRNA-199/214affectingtheepithelialovarian cancer stem cells differentiation and chemoresistance.

Ø 06/08~11/10 Postdoctoral Associate. OBGYN, School of Medicine, Yale Univ. New Haven, CT, USA

Research projects:

1) Study the molecular mechanisms of Twist1 in regulating ovarian cancer stem cell differentiation and acquisition of metastatic capacity
2) Study the mechanism of microRNA-221/222 affecting the PI3K/AKT pathway in ovarian cancer

3) Study the multipotency of Ovarian cancer stem-like cells

Ø 11/06~06/08 Postdoctoral Associate. Cardiovascular Division, Department of Medicine, Univ. of Minnesota, Minneapolis, MN, USA

Research projects:

1) Investigate the cellular and molecular mechanism of AMP-activated protein kinase (AMPK) function involved in atherosclerosis by using human

1

umbilicalvein endothelial cells (HUVEC)
2) Study the function of Core2-belta-1,6-N-acetylglucosaminyltransferase

(Core2GlcNAcT-1) in thrombosis and atherosclerosis by using leukocytes

Ø 2001~2006 Ph.D. graduate student Genetic Institute, Life science School, Fudan Univ. China

Research projects:

1) CloningandCharacterizationofanovelhumanubiquitin-conjugatingenzyme: hUBC16

2) StudythefunctionofahumanGlutathionePeroxidase7gene(hGPx7)incell signaling pathways

Awards and Memberships

2011- present Adjunct Professor, School of Medicine, Xi'an Jiaotong University

2009 - present Member, American Association of Cancer Research 2006 FUDAN outstanding student award, Fudan University
2005 hp Award, China Scholarship Council & HP company
2005 Xie-Xide Award, Fudan University

2005 Re-dian Award, Fudan University & Re-dian Company 2004 First Prize Graduate Scholarship, Fudan University 2003 Second Prize Graduate Scholarship, Fudan University 2002 Third Prize Graduate Scholarship, Fudan University

Research support

1) National Natural Science Foundation of China (550,000 Yuan) 12/2025

Role: PI

2) National Natural Science Foundation of China (682,000 Yuan) 12/2019

Title: The Role of miR-199a Inhibiting Differentiation Potential of Epithelial Ovarian Cancer Stem Cells to Tumor Vascular Progenitors Role: PI

01/2022-

01/2016-

Title: Ovarian Cancer Stem-Like cells-derived Exosome Improves Non-Stem Cancer cells Proliferation and Migration through Hotair/miR-222/CDK19 Axis

3) Natioal Natural Science Foundation of China –Young Scientist(230,000 Yuan) 01/2013-12/2015

Title: The Role of miR-199a Inhibiting Ovarian Cancer Stem Cells Chemoresistance Capacity

Role: PI

2

4) Sands Foundation (50,000$), 7/2011-6/2012 Title: In Vivo Model for Targeting Ovarian Cancer Stem Cells
Role: PI

5) The Honorable Tina Brozman Foundation(100,000$), 11/2010-06/2011 Title: Early Detection of Ovarian Cancer
Role: PI

6) R01 NIH(1,660,000)， 7/2008-5/2012 Title:MyD88-Bearing Tumors in Immune-regulation and Chemo-resistance

Role: Postdoctoral Associate

7) Burros Family Foundation (400,000$), Title: Ovarian Cancer Research
Role: Postdoctoral Associate

8) The Discovery to Cure Program (2,500,000$),
Title: Early Detection and Treatment for Ovarian Cancer Role: Postdoctoral Associate

Reviewer experience:

Reproductive Sciences，Theranostics, Oncogene

8/12009-7/2010

8/13/2008-7/31/2009

Publications:

1. 1)  Lili Fan, Han Lei, Ying Lin, Zhengwei Zhou, Guang Shu, Zhipeng Yan, Haotian Chen, Tianxiang Zhang,

   Gang Yin*.(2021) Identification of a Gene Set Correlated With Immune Status in Ovarian Cancer by Transcriptome-Wide Data Mining. Frontiers in Molecular Biosciences. (JCR分区: Q2) 2021 July 30; https://doi.org/10.3389/fmolb.2021.670666. (IF=5.246)

2. 2)  Gang Yin*.

   (JCR分区: Q2)

3. 3)  Jiaxin Liu, Yimin Li, Yaqi Gan, Qing Xiao, Ruotong Tian, Guang Shu, Gang Yin*.(

   (JCR 分区: Q1) 11; doi: 10.3389/fcell.2021.671211.

4. 4)  Xiao Q, Gan Y, Li Y, Fan L, Liu J, Lu P, Liu J, Chen A, Shu G, Yin G*. (2021) MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression. Oncogene. (JCR 分区: Q1) 2021 May;40(19):3364-3377. doi: 10.1038/s41388-021-01774-w. Epub 2021 Apr 16. PMID: 33863999. (IF=9.479)

5. 5)  Huang WL, Abudureheman T, Xia J, Chu L, Zhou H, Zheng WW, Zhou N, Shi RY, Li MH, Zhu JM, Qing K, Ji C, Liang KW, Guo S, Yin G*, Duan CW*. CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism. Frontiers in Cell and Developmental Biology (JCR 分区: Q1) 2021 Mar 4;9:641271. doi: 10.3389/fcell.2021.641271. PMID: 33748130. (IF=6.536)

6. 6)  Fan L, Lin Y, Lei H, Shu G, He L, Yan Z, Rihan H, Yin G*. (2020)A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer. Aging (Albany NY). (JCR 分区: Q1) 2020 Sep 20;12(18):18453-18475. doi: 10.18632/aging.103811. Epub ahead of print. PMID: 32950970; PMCID: PMC7585096.

7)

Rihan Hai, Liuer He, Guang Shu and

(JCR 分区: Q1)

3

(2021). Characterization of Histone Deacetylase

Mechanisms in Cancer Development. Frontiers in oncology

2021 Jul 29; doi:

10.3389/fonc.2021.70094 (IF=6.244)

2021)Identification of

ZNF26 as a prognostic biomarker in colorectal cancer by an integrated bioinformatic analysis. Frontiers

in Cell and Developmental Biology.

2021 Jun

(IF=6.536)

(IF=5.531)

Peng Y, Li Y, Li Y, Wu A, Fan L, Huang W, Fu C, Deng Z, Wang K, Zhang Y, Shu G*

HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer. Aging

, Yin G*. (2020)

(Albany NY).

2020 Sep 7;12(19):19375-19398. doi: 10.18632/aging.103824. PMID:

32897245.(IF=5.531)

Li Y, Liu J, Xiao Q, Tian R, Zhou Z, Gan Y, Li Y, Shu G*

, Yin G*. (2020) EN2 as an oncogene promotes

tumor progression via regulating CCL20 in colorectal cancer. Cell Death Dis.

30;11(7):604. doi: 10.1038/s41419-020-02804-3. PMID: 32732864 (IF=8.105)

Wu A, Zhang S, Liu J, Huang Y, Deng W, Shu G, Yin G*. (2020) Integrated Analysis of Prognostic and

2020 Jul

Immune Associated Integrin Family in Ovarian Cancer. Front Genet.

2020 Jul 17;11:705.

doi: 10.3389/fgene.2020.00705. PMID: 32765584.(IF=4.417)

Li J, Alvero AB, Nuti S, Tedja R, Roberts CM, Pitruzzello M, Li Y, Xiao Q, Zhang S, Gan Y, Wu X, Mor G

Yin G*. (2020)CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic

potential. Oncogene.

2020 May;39(20):3965-3979. doi: 10.1038/s41388-020-1269-5.

PMID: 32205869.(IF=9.479)

Fan L, Lei H, Zhang S, Peng Y, Fu C, Shu G,Yin G*. (2020) Non-canonical signaling pathway of SNAI2

induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10.

Theranostics.

32483426. (IF=11.556)

2020 Apr 27;10(13):5895-5913. doi: 10.7150/thno.43198. PMID:

He L, Li H, Wu A, Peng Y, Shu G,Yin G*. (2019) Functions of N6-methyladenosine and its role in cancer.

Mol Cancer.

2019 Dec 4;18(1):176. doi: 10.1186/s12943-019-1109-9. PMID:

31801551.(IF=27.401)

Li T, Zhou W, Li Y, Gan Y, Peng Y, Xiao Q, Ouyang C, Wu A, Zhang S, Liu J, Fan L, Han D, Wei Y, Shu

G, Yin G*. (2019)MiR-4524b-5p/WTX/β-catenin axis functions as a regulator of metastasis in cervical

cancer. PLoS One.

(JCR 分区: Q2)

2019 Apr 2;14(4):e0214822. doi: 10.1371/journal.pone.0214822.

Erratum in: PLoS One. 2019 Dec 17;14(12):e0226864. PMID: 30939162.(IF=3.117)

Li T, Li Y, Gan Y, Tian R, Wu Q, Shu G, Yin G*. (2019) Methylation-mediated repression of MiR-424/503

cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23.

Cell Cycle.

(JCR 分区: Q2)

2019 Jul;18(14):1601-1618. doi: 10.1080/15384101.2019.1624112. Epub

2019 Jun 9. PMID: 31135262.(IF=4.286)

Wu Q, Ren X, Zhang Y, Fu X, Li Y, Peng Y, Xiao Q, Li T, Ouyang C, Hu Y, Zhang Y, Zhou W, Yan W, Guo

K, Li W, Hu Y, Yang X, Shu G, Xue H, Wei Z, Luo Y, Yin G*. (2018) MiR-221-3p targets ARF4 and inhibits

the proliferation and migration of epithelial ovarian cancer cells. Biochem Biophys Res Commun.

2018 Mar 18;497(4):1162-1170. doi: 10.1016/j.bbrc.2017.01.002. Epub 2017 Jan 3. PMID:

28057486. (IF=3.426)

Gan Y, Li Y, Li T, Shu G, Yin G*. (2018)CCNA2 acts as a novel biomarker in regulating the growth and

apoptosis of colorectal cancer. Cancer Manag Res.

2018 Oct 31;10:5113-5124. doi:

10.2147/CMAR.S176833. PMID: 30464611.(IF=3.861)

Wu, A. , Shu, G. , Wang, J. , & Yin, G*. (2017)Targets and beyond: cancer stem cell elimination. Science

Bulletin,

(JCR 分区: Q1)

62(16):1104-1105.(IF=11.780)

Fu X, Li Y, Alvero A, Li J, Wu Q, Xiao Q, Peng Y, Hu Y, Li X, Yan W, Guo K, Zhou W, Wang Y, Liu J, Zhang

Y, Mor G, Wen J, Yin G*. (2016) MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. Oncotarget. 2016 Dec 6;7(49):80633-80654. doi:

10.18632/oncotarget.13017. PMID: 27811362.(IF=5.008)

Zhou W, Yang X, Dai Y, Wu Q, He G, Yin G*. (2016) Survey of cervical cancer survivors regarding quality

of life and sexual function. J Cancer Res Ther.

2016 Apr-Jun;12(2):938-44. doi:

10.4103/0973-1482.175427. PMID: 27461678.(IF=1.329)

Nuti, S. V., Mor, G., Li, P., & Yin, G*. (2014). Twist and ovarian cancer stem cells: implications for

chemoresistance and metastasis. Oncotarget, 5(17), 7260. (IF=5.008)

Yin, G., Alvero, A. B., Craveiro, V., Holmberg, J. C., Fu, H. H., & Montagna, M. K., et al. (2012).

Constitutive proteasomal degradation of twist-1 in epithelial ovarian cancer stem cells impacts

differentiation and metastatic potential. Oncogene, 32(1), 39.(IF=7.932)

Liu M, Mor G, Cheng H, et al. High Frequency of Putative Ovarian Cancer Stem Cells With CD44/CK19

Coexpression Is Associated With Decreased Progression-Free Intervals In Patients With Recurrent

Epithelial Ovarian Cancer[J]. Reproductive Sciences, 2013, 20(5):605-15.

Yin, G., Chen, R., Alvero, A. B., Fu, H. H., Holmberg, J., & Glackin, C., et al. (2009). Twisting stemness,

inflammation and proliferation of epithelial ovarian cancer cells through mir199a/214. Oncogene,29(24),

3545. (IF=7.932)

Yin, G., Craveiro, V., Holmberg, J., Fu, H. H., Alvero, A., & Mor, G. (2010). Epithelial-mesenchymal

transition generates cancer stem cells with metastatic potential. Reproductive Sciences 2010 Mar 17(3):

111A-111A. (IF=2.429)

Mor, G., Yin, G., Chefetz, I., Yang, Y., & Alvero, A. (2011). Ovarian cancer stem cells and

inflammation. Cancer Biology & Therapy, 11(8), 708. (IF=2.921)

Yin, G., Ji, C., Zeng, L., Wang, Z., Wang, J., & Shen, Z., et al. (2006). Cloning and characterization of a

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(JCR 分区: Q1) (JCR 分区: Q2)

(JCR 分区: Q1)

(JCR 分区: Q1) (JCR 分区: Q1)

4

(JCR 分区: Q3)

(JCR分区: Q1) (JCR分区: Q4)

(JCR

*,

novel krab-domain-containing zinc finger gene (znf284l). Molecular Biology Reports, 33(2), 137-144.

(IF=1.698)

Yin, G., Ji, C., Wu, T., Shen, Z., Xu, X., & Xie, Y., et al. (2006). Cloning, characterization and subcellular

localization of a gene encoding a human ubiquitin-conjugating enzyme (e2) homologous to the

arabidopsis thaliana ubc-16 gene product. Frontiers in Bioscience, 11(10), 1500. (IF=2.484)

Wu M, Yin G (co-first author), Zhao X, Ji C, Gu S, Tang R, Dong H, Xie Y, Mao Y. (2006).Human RAB24,

27) 28)

interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A 29)

30) 31)

and GABARAP. Int J Mol Med,17(5): 749-754. (IF=2.348)

Yin, G., Dai, J. L., Ji, C., Ni, X., Shu, G., & Ye, X., et al. (2003). Cloning and characterization of the human

ift20 gene *. Molecular Biology Reports, 30(4), 255-60. (IF=1.698)

Chen J, Yin G (co-first author), Lu Y, Lou M, Cheng H, Ni X, Hu G, Luo C, Ying K, Xie Y, Mao Y. (2004).

Cloning and characterization of a novel human cDNA encoding a J-domain protein (DNAJA5) from the

fetal brain. Int J Mol Med. 13(5):735-740. (IF=2.348)

Ye, X., Ji, C., Yin, G., Tang, R., Zeng, L., & Gu, S., et al. (2004). Characterization of a human sec14-like

protein cdna sec14l3 highly homologous to human spf/tap. Molecular Biology Reports, 31(1), 59-63.

(IF=1.698)