Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer.

Release time:2023-02-09

Impact Factor:8.501

DOI number:10.1038/sdata.2018.284.

Affiliation of Author(s):Xiangya Hospital, Central South University

Teaching and Research Group:Department of Clinical Pharmacology

Journal:Scientific data.

Place of Publication:England

Key Words:Genotype, Cancer genetics

Abstract:Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step.

Co-author:Guo Ao-Xiang, Zhao Zhen-Yu, Liu Ying-Zi, Wu Ji-Chu, Li Min, Hu Cheng-Ping, Gao Yang, Zhou Hong-Hao

First Author:Wang Lei-Yun, Cui Jia-Jia, Liu Jun-Yan

Indexed by:Journal paper

Correspondence Author:Yin Ji-Ye

Document Code:180284

Discipline:Medicine

First-Level Discipline:Pharmaceutical Science

Document Type:J

Volume:5

Issue:1

Page Number:1-8

ISSN No.:2052-4463

Translation or Not:no

Date of Publication:2018-12-11

Included Journals:SCI

Links to published journals:https://www.nature.com/articles/sdata2018284