The role of CSDE1 in translational reprogramming and human diseases

Release time:2023-02-13

Impact Factor:7.525

DOI number:10.1186/s12964-019-0496-2

Affiliation of Author(s):Xiangya Hospital, Central South University

Teaching and Research Group:Department of Clinical Pharmacology

Journal:Cell Communication and Signaling

Funded by:National Natural Science Foundation of China (81773823, 81573463) and National Major Science and Tec

Key Words:CSDE1; Cancer; RNA binding protein; Reprogramming; Translation initiation; UNR

Abstract:CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirectional. It not only promotes and represses the translation of RNAs but also increases and decreases the abundance of RNAs. However, the mechanisms underlying this phenomenon are still unknown. In this review, we propose a "protein-RNA connector" model to explain this bidirectional role and depict its three versions: sequential connection, mutual connection and facilitating connection. As described in this molecular model, CSDE1 binds to RNAs and cooperates with other protein regulators. CSDE1 connects with different RNAs and their regulators for different purposes. The triple complex of CSDE1, a regulator and an RNA reprograms translation in different directions for each transcript. Meanwhile, a number of recent studies have found important roles for CSDE1 in human diseases. This model will help us to understand the role of CSDE1 in translational reprogramming and human diseases.

Co-author:Jia-Jia Cui, Lei-Yun Wang, Ji-Ye Yin

First Author:Ao-Xiang Guo

Indexed by:Journal paper

Discipline:Medicine

First-Level Discipline:Pharmaceutical Science

Document Type:J

Volume:18

Issue:14

Number of Words:9661

ISSN No.:1478-811X

Translation or Not:no

Date of Publication:2020-01-27

Included Journals:SCI

Links to published journals:https://doi.org/10.1186/s12964-019-0496-2