Gene-gene and gene-environment interactions influence platinum-based chemotherapy response and toxicity in non-small cell lung cancer patients

Release time:2017-07-11

Impact Factor:4.996

DOI number:10.1038/s41598-017-05246-8

Affiliation of Author(s):Xiangya Hospital, Central South University

Teaching and Research Group:Department of Clinical Pharmacology

Journal:Scientific reports

Place of Publication:England

Key Words:NSCLC, platinum, response, toxicity, gene-gene and gene-environment interactions

Abstract:Platinum-based chemotherapy is a major therapeutic regimen of lung cancer. Various single nucleotide polymorphisms (SNPs) reported were associated with platinum-based chemotherapy response and drug toxicity. However, neither of the studies explored this association from SNP-SNP interaction perspective nor taking into effects of SNP-environment consideration simultaneously. We genotyped 504 polymorphisms and explore the association of gene-gene and gene-environment interactions with platinum-based chemotherapy response and toxicity in 490 NSCLC patients. 16 SNPs were found significantly associated with platinum-based chemotherapy, and they were picked out as study object in the validation cohort. We recruited 788 patients in the validation cohort. We found that HSPD1 rs17730989-SUMF1 rs2633851 interaction was associated with platinum-based chemotherapy-induced hematologic toxicity (adjusted OR = 0.233, P = 0.018). In addition, the combined effect of ABCG2 rs2231142-CES5A rs3859104 was significantly associated with overall toxicity (adjusted OR = 8.044, P = 4.350 × 10-5). Besides, the model of ARHGAP26 rs3776332-ERCC6 rs2228528-SLC2A1 rs4658-histology was associated with platinum-based chemotherapeutic response. Gene-gene and gene-environment interactions have been identified to contribute to chemotherapy sensitivity and toxicity. They can potentially predict drug response and toxicity of platinum-based chemotherapy in NSCLC patients.

Co-author:Zhao-Qian Liu, Hong-Hao Zhou, Wei-Jing Gong, Tao Zhu

First Author:Lei-Yun Wang, Jia-Jia Cui

Indexed by:Journal paper

Correspondence Author:Ji-Ye Yin

Document Type:J

Volume:7

Issue:1

Page Number:5082

ISSN No.:2045-2322

Translation or Not:no

Date of Publication:2017-07-11

Included Journals:SCI

Links to published journals:http://www.nature.com/srep/index.html