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刘珍宝，男，教授，博士生导师，中南大学湘雅药学院药剂学系。湖南省杰出青年基金获得者，湖湘青年英才，中南大学升华育英人才，获评湖南省第二届优秀研究生导师，湖南省大学生创新创业优秀导师，中南大学教学竞赛“三十佳”，获得中南大学研究生课堂教学质量优秀奖，中南大学教学成果二等奖。致力于分子药剂学，功能核酸及纳米材料在药物传递系统和分子诊断中的研究。博士毕业于清华大学北京协和医学院，期间到美国加州大学伯克利分校留学，后到美国佛罗里达大学从事博士后研究。取得一系列研究成果，发表多篇高水平论文，在Advanced Science、Biomaterials、Small、Biosensor and Bioelectronics、Journal of Controlled Release、Advanced Healthcare Materials、TrAC-Trends in Analytical Chemistry、Chemical Engineering Journal、Materials Horizons等期刊发表第一作者或通讯作者SCI论文40余篇（13篇IF＞10，高被引论文3篇），发表论文获得国际同行的广泛关注。作为通讯作者参编Springer专著1部，ACS publication 专著1部，Elsevier专著1部，参编出版《药学概论》教材1部。授权发明专利5项。主持国家自然科学基金面上项目，国家自然科学基金青年基金，湖南省杰出青年科学基金，湖南省自然科学基金青年基金和面上项目，湖湘青年英才项目，教育部博士点新教师基金，中国博士后科学基金一等资助，中国博士后国际交流计划，中南大学创新驱动计划，升华育英计划等科研项目。参与湖南省重点研发计划项目，国家自然科学基金面上项目及青年基金项目，国家重大科学研究计划，天津市应用基础重点项目，天津市应用基础及前沿技术研究计划重点项目。曾担任湖南省长沙市科学技术局青年科技特派员。现为中国抗癌协会纳米肿瘤学专业委员会常务委员。

刘珍宝 (ZHENBAO LIU), PH.D. 教授

Professor, Department of Pharmaceutics, 湘雅药学院 Xiangya School of Pharmaceutical Sciences, 中南大学 Central South University (CSU)

172 Tongzipo Road, Changsha, Hunan, China, 410013, CHINA, Email: zhenbaoliu@csu.edu.cn

 

工作经历 POSITIONS AND EMPLOYMENT

—  2022-present 教授 Professor, Central South University, Xiangya School of Pharmaceutical Sciences, Department of Pharmaceutics

— 2015-2022 副教授 Associate Professor, Central South University, Xiangya School of Pharmaceutical Sciences, Department of Pharmaceutics

— 2012-2015 讲师 Lecturer, Central South University, Xiangya School of Pharmaceutical Sciences, Department of Pharmaceutics 

 

教育经历 EDUCATION ANDTRAINING

— 2015-2017 Postdoctoral Fellow, 佛罗里达大学 University of Florida (UF)  Advisor: Weihon Tan 谭蔚泓 院士 

Department of Chemistry and Department of Physiology and Functional Genomics

Center for Research at the Bio/Nano Interface

Genetics institute and Shands Cancer Center

— 2013-2015 Postdoctoral Fellow, 中南大学 Central South University  Advisor: Juewen Liu 刘珏文 教授

Department of Pharmaceutics,Xiangya School of Pharmaceutical Sciences

— 2010-2011 Joint Ph.D., 加州大学伯克利分校 University of California, Berkeley  Advisor: Luke P. Lee

Department of Bioengineering, UCB / Lawrence Berkeley National Laboratory (LBNL)

— 2006-2012 Ph.D., 清华大学 Tsinghua University (THU) | 北京协和医学院Peking Union Medical College (PUMC) 中国医学科学院Chinese Academy of Medical Sciences (CAMS), Advisors: Cunxian Song | Xigang Leng 宋存先|冷希岗 研究员

Institute of Biomedical Engineering

— 2002-2006 B.S., 沈阳药科大学Shengyang Pharmaceutical University (SPU) Advisors: Gang Chen 程刚 教授

Department of Pharmacy, School of Pharmacy

 

获奖与荣誉 HONORS AND AWARDS

—    湖南省自然科学杰出青年基金 Hunan Provincial Natural Science Outstanding Youth Fund

— 湖湘青年英才Huxiang Young Talent

—    湖南省第二届优秀研究生导师 Outstanding Postgraduate Tutor of Hunan Province

—    湖南省大学生创新创业优秀导师 Hunan Provincial Excellent mentor of Innovation and entrepreneurship of College Students 

— 中南大学第十届教学竞赛“三十佳” “Top Thirty” in the 10^th Central South University Teaching Competition

 

研究领域 RESEARCH AREAS

— 药物新剂型 New Dosage Forms of Medicine

— 功能核酸及纳米材料在药物传递系统和分子诊断中的应用 Functional Nucleic Acid and Nanomaterials in the Drug Delivery and Molecular Diagnosis

 

研究成果 RESEARCH OUTCOME

— 期刊论文    JOURNAL PAPERS

1. Yaqin Hu, Ying Wang, Jianhua Yan, Nachuan Wen, Hongjie Xiong, Shundong Cai, Qunye He, Dongming Peng, Zhenbao Liu,* and Yanfei Liu* Dynamic DNA Assemblies in Biomedical Applications, Advanced Science, 2020, 7(14): 2000557. (IF: 15.84)

2. Ying Wang, Jianhua Yan, Nachuan Wen, Hongjie Xiong, Shundong Cai, Qunye He, Yaqin Hu, Dongming Peng, Zhenbao Liu*, Yanfei Liu*, Metal-organic frameworks for stimuli-responsive drug delivery. Biomaterials, 2020, 230:119619. (IF: 10.317)

3. Ying Wang, Yaqin Hu, Qunye He, Jianhua Yan, Hongjie Xiong, Nachuan Wen, Shundong Cai, Dongming Peng, Yanfei Liu*,Zhenbao Liu*, Metal-organic frameworks for virus detection, Biosensors and Bioelectronics, 2020, 169:112604. (IF: 10.257)

4. Peifang Du, Jianhua Yan, Shuo Long, Hongjie Xiong, Nachuan Wen, Shundong Cai, Yirong Wang, Dongming Peng, Zhenbao Liu* and Yanfei Liu*, Tumor Microenvironment and NIR Laser Dual Responsive Release of Berberine 9-O-pyrazole Alkyl Derivative Loaded in Graphene Oxide Nanosheets for Chemo-photothermal Synergetic Cancer Therapy, Journal of Materials Chemistry B, 2020, 8, 4046-4055.

5. Shundong Cai, Jianhua Yan, Hongjie Xiong, Qing Wu, Hang Xing, Yanfei Liu, Song Liu*, Zhenbao Liu*, Aptamer-Functionalized Molybdenum Disulfide Nanosheets for Tumor Cell Targeting and Lysosomal Acidic Environment/NIR Laser Responsive Drug Delivery to Realize Synergetic Chemo-Photothermal Therapeutic Effects, International Journal of Pharmaceutics, 2020, 590, 119948.

6. Hongjie Xiong, Jianhua Yan, Shundong Cai, Qunye He, Nachuan Wen Ying Wang, Yaqin Hu, Dongming Peng, Yanfei Liu*, Zhenbao Liu*, Aptamer-Pyropheophorbide a Conjugates with Tumor Spheroid Targeting and Penetration Abilities for Photodynamic Therapy, Molecular Pharmaceutics, 2020, 17(8): 2882-2890.

7. Qunye He, Qing Wu, Xiangran Feng, Ziyan Liao, Wenyao Peng, Yanfei Liu, Dongming Peng, Zhenbao Liu*, Miao Mo*, Interfacing DNA with nanoparticles: Surface science and its applications in biosensing, Int J Biol Macromol., 2020, 151:757-780.

8. Qunye He^†, Jun Chen^†, Jianhua Yan, Shundong Cai, Hongjie Xiong, Yanfei Liu, Dongming Peng, Miao Mo*, Zhenbao Liu*, Tumor microenvironment responsive drug delivery systems, Asian Journal of Pharmaceutical Sciences, 2020, 15 (4): 16-448.

9. Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu*, Yanfei Liu*, Aptamer Based Targeted Drug Delivery Systems: Current Potential and Challenges. Current Medicinal Chemistry, 2020, 27, 2189-2219. (高被引论文)

10. Jianhua Yan, Hongjie Xiong, Shundong Cai, Nachuan Wen, Qunye He, Yanfei Liu, Dongming Peng and Zhenbao Liu*, Advances in Aptamer Screening Technologies, TALANTA, 2019, 200:124-144.

11. Hongjie Xiong, Jianhua Yan, Shundong Cai, Qunye He, Dongming Peng, Zhenbao Liu*, Yanfei Liu*, Cancer protein biomarker discovery based on nucleic acid aptamers. Int J Biol Macromol., 2019,132:190-202.

12. Shundong Cai, Jianhua Yan, Hongjie Xiong, Yanfei Liu, Dongming Peng and Zhenbao Liu*, Investigations on the interface of nucleic acid aptamers and binding targets. Analyst. 2018, 143(22):5317-5338.

13. Daipeng Xiao, Fen He, Dongming Peng, Junying Peng, Min Zou, Yanfei Liu*, Zhenbao Liu*, Synthesis and anticancer activity of 9-O-pyrazole alkyl substituted berberine derivatives. Anticancer Agents Med Chem. 2018, 18(11):1639-1648.

14. Zhenbao Liu, Chunyan Wang, Yanfei Liu, Dongming Peng. Cefepime loaded O-carboxymethyl chitosan microspheres with sustained bactericidal activity and enhanced biocompatibility. J Biomater Sci Polym Ed. 2017, 28(1):79-92.

15. Zhenbao Liu, Xiaohong Wang, Hang Zhang, Shanshan Zhang, Yiqian Li, Yanfei Liu*, Dongming Peng*, Synthesis and anti-inflammatory effects of a series of novel 9-O-substituted berberine derivatives. Medicinal Chemistry Research. 2017, 26 (3):672-679.

16. Zhenbao Liu, Yanfei Liu*, Dongming Peng. Hydroxylation of multi-walled carbon nanotubes: Enhanced biocompatibility through reduction of oxidative stress initiated cell membrane damage, cell cycle arrestment and extrinsic apoptotic pathway. Environ Toxicol Pharmacol. 2016, 47:124-130.

17. Zhenbao Liu, Huanzhe Zhao, Lingyun He, Yao Yao, Yanbin Zhou, Jianping Wu, Juewen Liu*, Jinsong Ding*, Aptamer density dependent cellular uptake of lipid capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells, RSC Adv., 2015, 5, 16931-16939.

18. Zhenbao Liu, Yanfei Liu*, Dongming Peng, Carboxylation of multiwalled carbon nanotube attenuated the cytotoxicity by limiting the oxidative stress initiated cell membrane integrity damage, cell cycle arrestment and death receptor mediated apoptotic pathway. Journal of Biomedical Materials Research, Part A. 2015,103(8):2770-7.

19. Zhenbao Liu, Shanshan Chen, Biwu Liu, Jianping Wu, Yanbin Zhou, Lingyun He, Jinsong Ding*, and Juewen Liu*, Intracellular detection of ATP using an aptamer beacon covalently linked to graphene oxide resisting nonspecific probe displacement. Analytical Chemistry, 2014, 86(24):12229-35. (IF: 6.785, Nature Index)

20. Zhenbao Liu, Biwu Liu, Jingsong Ding, Juewen Liu*, Fluorescent sensors using DNA-functionalized graphene oxide, Analytical and Bioanalytical Chemistry, 2014, 406(27):6885-902.

21. Zhenbao Liu, Yanfei Liu*, Dongming Peng, Hydroxylation of multi-walled carbon nanotubes reduces their cytotoxicity by limiting the activation of mitochondrial mediated apoptotic pathway. J Mater Sci Mater Med, 2014, 25: 1033-1044.

22. Zhenbao Liu, Bo Zhou*, Haiqing Wang, Feng Lu, Tianjun Liu, Cunxian Song, Xigang Leng*. Highly sensitive detection of human IgG using a novel bio-barcode assay combined with DNA chip technology. Journal of Nanoparticle Research, 2013, 15(9):1964.

23. Zhenbao Liu, Xia Dong, Liping Song, Hailing Zhang, Lanxia Liu, Dunwan Zhu, Cunxian Song, Xigang Leng*, Carboxylation of multi-walled carbon nanotube enhanced its biocompatibility with L02 cells through decreased activation of mitochondrial apoptotic pathway. Journal of Biomedical Materials Research, Part A, 2014, 102(3):665-73.

24. Ren Cai, Dan Yang, Shengjie Peng, Xigao Chen, Yun Huang, Yuan Liu, Weijia Hou, Shengyuan Yang, Zhenbao Liu, and Weihong Tan*, Single Nanoparticle to 3D Supercage: Framing for an Artificial Enzyme System. J Am Chem Soc., 2015,137(43):13957-63.

25. Ye Liu, Jinfeng Liu, Dandan Chen, Xiaosha Wang, Zhenbao Liu, Hui Liu, Lihui Jiang, Changfeng Wu, Yingping Zou,* Quinoxaline-based semiconducting polymer dots for in vivo NIR-II fluorescence imaging, Macromolecules, 2019, 52 (15), 5735-5740.

26. Daipeng Xiao, Zhenbao Liu, Shanshan Zhang, Mi Zhou, Fen He, Ming Zou, Junying Peng, Xiong Xie, Yanfei Liu*, Dongming Peng*, Berberine Derivatives with Different Pharmacological Activities via Structural Modification, Mini Rev Med Chem. 2018, 18(17):1424-1441.

27. Shanshan Zhang, Xiaohong Wang, Weicheng Yin, Zhenbao Liu, Mi Zhou, Daipeng Xiao, Yanfei Liu, Dongming Peng. Synthesis and hypoglycemic activity of 9-O-(lipophilic group substituted) berberine derivatives. Bioorg Med Chem Lett. 2016, 26(19):4799-803.

28. Jing Tang, Zhenbao Liu, Yue Zhang, Ling Wang, Dai Li, Jinsong Ding* and Xuehua Jiang*, Fluorofenidone-loaded PLGA microspheres for targeted treatment of paraquat-induced acute lung injury in rats, RSC Adv., 2015,5, 30153-30159.

29. Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu, Jinsong Ding*, Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells, Journal of Drug Targeting, 2014, 22(1):57-66.

30. Hailing Zhang, Dunwan Zhu, Liping Song, Lanxia Liu, Xia Dong, Zhenbao Liu, Xigang Leng*, Arginine conjugation affects the endocytic pathways of chitosan/DNA nanoparticles, Journal of Biomedical Materials Research, Part A. 2011, 98(2):296-302.

31. Yanfei Liu*, Dongming Peng, Kelong Huang, Suqin Liu, Zhenbao Liu, Preparation and thermal degradation kinetics of terpolymer poly (e-caprolactone-co-1,2-butylene carbonate), Polymer Degradation and Stability, 2010, 95: 2453-2460.

32. Yanfei Liu*, Dongming Peng, Kelong Huang, Suqin Liu, Zhenbao Liu, Preparation and Properties of Poly(propylene carbonate maleate) Microcapsules for Controlled Release of Pazufloxacin Mesilate, Journal of Applied Polymer Science, 2011, 122(5), 3248-3254. 

— 专著 BOOK CHAPTERS

Yanfei Liu, Zhenbao Liu* “Aptamer based drug delivery” Chapter in “Aptamers for Medical Applications-From Diagnosis to Therapeutics”. Springer, 2020.(in press)

— 授权专利 ISSUED PATENTS

Yanfei Liu,  Daipeng Xiao,  Zhenbao Liu,  Fen He, Dongming Peng,  “A berberine 9- position pyrazole derivative and its preparation and application”, Patent Number: ZL 2018 1 0067393.6  Date of Patent: 10/08/2019

— 基金项目 GRANTS

1. 湖湘青年英才计划Huxiang Young Talent Support Program (2018RS3005)

2. 国家自然科学基金青年基金National Natural Science Foundation of China (81301258)

3. 湖南省自然科学基金青年基金Natural Science Foundation of Hunan Province (13JJ4029)

4. 湖南省自然科学基金面上项目Natural Science Foundation of Hunan Province (2016JJ2161)

5. 教育部高等学校博士点新教师基金 Specialized Research Fund for the Doctoral Program of Higher Education of China (20130162120078)

6. 中国博士后科学基金面上项目一等资助 China Postdoctoral Science Foundation (2013M540644)

7. 中国博士后国际交流计划 International Postdoctoral Exchange Fellowship Program [(2014)29(20140014)]

8. 中南大学创新驱动计划Innovation-Driven Project of Central South University (2020CX048)

9. 中南大学升华育英计划Shenghua Yuying Project of Central South University

   

 特邀报告 INVITED TALKS

1. Zhenbao Liu, “Application of aptamer based drug delivery systems fortumor targeted therapy”, The fourth Pujiang Medicine Fourm, May. 16-17, 2017, Shanghai, China.

2. Zhenbao Liu, “Aptamer based drug delivery and molecular diagnosis”, Aptamer Strategic Seminar and Industrial Capital Matching Meeting, Nov. 18-19, 2017, Hefei, China.

3. Zhenbao Liu, “DNA logic gate performing on the interface of nanoparticles and cells for accurate targeting”, The 3rd International Conference on Nanomedicine, China Nanomedicine, Oct. 15-17, 2018, Shanghai, China.

4. Zhenbao Liu, “Application of micro- and nanoparticles in drug delivery and molecular diagnosis”, The 10th Annual Meeting of Chinese Society of Particuology and Particle Technology on Both Sides of the Taiwan Straits, Aug. 9-12, 2018, Shenyang, China.

5. Zhenbao Liu, “Drug delivery and molecular diagnosis based on nanomaterials and functional nucleic acids”, The Fourth National Biological Granule Conference and Academic Seminar on Industrial Pharmaceutics Industrialization Progress, Nov. 9-10, 2019, Shenzhen, China.

6. Zhenbao Liu, “Molecular diagnosis and drug delivery system based on two-dimensional nanomaterials and functional nucleic acids”, China Biomedical Engineering Conference and Innovative Medical Summit, Nov. 14-16, 2019, Jinan, China.

 

教学 TEACHING

— 本科生课程

Lecture: 药剂学A Pharmaceutics A

Lecture: 药剂学B Pharmaceutics B

Lecture: 药剂学实验Pharmaceutics Experiments

Lecture: 药学英语 Pharmaceutical English

— 研究生课程

Lecture:现代药剂学选论Selected topics on Modern Pharmaceutics

Lecture: 现代药物分析学选论Selected topics on Modern Pharmaceutical Analysis

Lecture: 药学前沿Frontier of Pharmacy

Lecture: 现代药学评价方法Modern Pharmaceutical Evaluation

Lecture: 现代药剂学研究进展Advances in Modern Pharmaceutics

Lecture: 分子影像学Molecular Imaging

 

学术活动 PROFESSIONAL ACTIVITIES

— 学会委员Committee Member

中国颗粒学会生物颗粒分会会委员

Biological Granule, Chinese Society of Particuology

中国生物医学工程学会纳米医学与工程分会青年委员

Nano-medicine and Engineering, Chinese Society of Biomedical Engineering, CSBME

中国康复医学会药学与康复专业委员会委员

— 编委Editorships

青年编委Youth Editorial Board

亚洲药物制剂科学Asian Journal of Pharmaceutical Sciences (AJPS)青年编委

中国化学快报Chinese Chemical Letters (CCL)青年编委

VIEW期刊青年编委

Exploration期刊青年编委

Acta Materia Medica (AMM)期刊青年编委

— 期刊审稿人Journal Paper Reviewer

Small

ACS Applied Materials & Interfaces

International Journal of Pharmaceutics

Nature Scientific Reports

Biotechnology Progress

ACS Combinatorial Science

Journal of Nanoparticle Research

Journal of Applied Polymer Science

Journal of Biomedical Materials Research, Part A

Chinese Science Bulletin

Asian Journal of Pharmaceutical Sciences

Pathogens and Global Health

TALANTA

Journal of Advanced Research

Materials Science & Engineering C

— 湖南省长沙市科技局青年科技特派员

Young Science and Technology Commissioner of Changsha Science and Technology Bureau of Hunan Province