Impact Factor:22.556
Teaching and Research Group:Department of Pathophysiology
Journal:Clin Microbiol Rev .
Funded by:the National Natural Science Foundation of China (NSFC)
Key Words:acute respiratory distress syndrome; hemophagocytic lymphohistiocytosis; human coronavirus.
Abstract:The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in Wuhan, China, introduced the third highly pathogenic coronavirus into humans in the 21st century. Scientific advance after the severe acute respiratory syndrome coronavirus (SARS-CoV) epidemic and Middle East respiratory syndrome coronavirus (MERS-CoV) emergence enabled clinicians to understand the epidemiology and pathophysiology of SARS-CoV-2. In this review, we summarize and discuss the epidemiology, clinical features, and virology of and host immune responses to SARS-CoV, MERS-CoV, and SARS-CoV-2 and the pathogenesis of coronavirus-induced acute respiratory distress syndrome (ARDS). We especially highlight that highly pathogenic coronaviruses might cause infection-associated hemophagocytic lymphohistiocytosis, which is involved in the immunopathogenesis of human coronavirus-induced ARDS, and also discuss the potential implication of hemophagocytic lymphohistiocytosis therapeutics for combating severe coronavirus infection.
First Author:Chao Quan,Caiyan Li,Han Ma
Indexed by:Other
Correspondence Author:Yisha Li,Huali Zhang（通讯作者）
Discipline:Medicine
Issue:2020 Oct 14;34(1):e00074-20.
Translation or Not:no
Included Journals:SCI