Impact Factor:1.995
Journal:Mol Genet Genomic Med.
Key Words:G6PT, glycogen storage disease type Ib, gout, leukocytopenia, SLC37A4
Abstract:Background Glycogen storage disease (GSD) type Ib is an autosomal recessive disease caused by defects of glucose‐6‐phosphate transporter (G6PT), encoded by the SLC37A4 gene. To date, over 100 mutations have been revealed in the SLC37A4 gene. GSD‐Ib patients manifest a metabolic phenotype of impaired blood glucose homeostasis and also carry the additional complications of neutropenia and myeloid dysfunction. Methods Here, we present two daughters with an initial diagnosis of gout in a Chinese consanguineous family. Whole‐exome sequencing was performed to identify the mutations. The mechanism of leukocytopenia was investigated. Results Whole‐exome sequencing analysis of the proband identified a novel homozygous p.P119L mutation in SLC37A4, leading to a diagnosis of GSD‐Ib. We found that the potential pathogenic p.P119L mutation leads to an unusual phenotype characterized by gout at onset, and GSD‐Ib arising from this variant also manifests multiple metabolic abnormalities, leukocytopenia, and anemia, but no hepatomegaly. The leukocytes from the proband showed increased mRNA levels of sXBP‐1, BIP, and CHOP genes in the unfolded protein response pathway, and enhanced Bax mRNA and caspase‐3 activity, which might contribute to leukocytopenia. Conclusion Our findings broaden the variation spectrum of SLC37A4 and suggest no strict genotype–phenotype correlations in GSD‐Ib patients.
Co-author:Haiyan Tang,Liping Duan,Xiaoxia Zuo,Xiaoliu Shi,Yisha Li,Hongjun Zhao
First Author:Qianyun Xu
Indexed by:Unit Twenty Basic Research
Correspondence Author:Huali Zhang（通讯作者）
Discipline:Medicine
First-Level Discipline:Basic Medicine
Issue:2021 Jan;9(1):e1568.
Translation or Not:no
Included Journals:SCI