周鸣, 博士，研究员，硕士生/博士生/博士后导师，肿瘤研究所副所长，国家卫健委癌变原理重点实验室副主任，中南大学531人才，中国研究型医院学会病毒肿瘤学专业委员会常务委员，湖南省免疫学会常务理事，湖南省病理生理学会常务理事、肿瘤专业委员会副主任委员、秘书长。2003年和2006年分别获得病理学与病理生理学专业硕士、博士学位，2007-2009年在美国南阿拉巴马大学Mitchell肿瘤研究所从事博士后研究。长期从事鼻咽癌和乳腺癌为主的恶性肿瘤功能基因组学、葡萄糖代谢、肿瘤耐药及小鼠发育生物学研究。近年来竞争性获得（主持）国家863课题、国家重点研发项目（子课题）、国家自然科学基金、湖南省重点研发项目及湖南省自然科学基金重点项目等16项；发表科研论文120余篇，其中第一作者或通讯作者论文49篇，代表性第一或通讯作者论文发表在Oncogene、Cell Mol Immunol、J Exp Clin Cancer Res、J Biol Chem、Cell Death Dis、Mol Cancer、Cancer Sci、J Proteomics和J Cell Biochem等国际重要期刊，副主编或参编专著3本；申报国家发明专利5项，其中3项已授权；获得湖南省科技进步一等奖和中华医学科技奖各1项；做为指导教师获得第四届全国大学生基础医学创新论坛暨实验设计大赛二等奖；是卢惠霖优秀教师奖和湖南省优秀博士毕业生奖获得者，国家自然科学基金、北京市和湖南省自然科学基金评审专家。现已毕业博士研究生7名、硕士研究生10名，另有3名博士、4名硕士研究生在读。

代表性论文如下：

1.       Wei J, Li M, Chen S, Xue C, Zheng L, Duan Y, Deng H, Fan S, Xiong W, Zhou M*. CircBRD7 attenuates tumor growth and metastasis in nasopharyngeal carcinoma via epigenetic activation of its host gene. Cancer Sci. 2024 Jan;115(1): 139-154

2.       Li M#, Duan Y#, Wei J, Chen S, Xue C, Zheng L, Deng H, Fan S, Xiong W, Li G, Tan M, Tang F, She K*, Zhou M*. Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression. Am J Cancer Res. 2023 Aug 15;13(8): 3763-3780.

3.       Wei J, Li M, Xue C, Chen S, Zheng L, Deng H, Tang F, Li G, Xiong W, Zeng Z, Zhou M*. Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression. J Exp Clin Cancer Res. 2023 Apr 15;42(1): 86.

4.       Li M, Wei Y, Liu Y, Wei J, Zhou X, Duan Y, Chen S, Xue C, Zhan Y, Zheng L, Deng H, Tang F, Fan S, Xiong W, Li G, Tan M, Zhou M*. BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma. Cell Death Dis, 2023 Feb 14;14(2): 121

5.       Luo Y, Wang X, Niu W, Zhou Y, Li M, Ma J, Yang J, Fan S, Zeng Z, Xiong W, Li X, Li G, Xiao J, Zhou M*. BRD7 Stabilizes P53 via Dephosphorylation of MDM2 to Inhibit Tumor Growth in Breast Cancer Harboring Wild-type P53. J Cancer. 2022 Feb 28;13(5):1436-1448

6.       Ran Zhao, Yukun Liu, Chunchun Wu, Mengna Li, Yanmei Wei, Weihong Niu, Jing Yang, Songqing Fan, Yong Xie, Hui Li, Wei Wang, Zhaoyang Zeng, Wei Xiong, Xiaoling Li, Guiyuan Li and Ming Zhou*. BRD7 promotes cell proliferation and tumor growth through stabilization of c-Myc in colorectal cancer. Front Cell Dev Biol, 2021 May 24;9: 659392

7.       Niu W, Luo Y, Zhou Y, Li M, Wu C, Duan Y, Wang H, Fan S, Li Z, Xiong W, Li X, Li G, Ren C, Li H, Zhou M*. BRD7 suppresses invasion and metastasis in breast cancer by negatively regulating YB1-induced epithelial- mesenchymal transition. J Exp Clin Cancer Res. 2020 Feb 7;39(1):30

8.       Li M, Liu Y, Wei Y, Wu C, Meng H, Niu W, Zhou Y, Wang H, Wen Q, Fan S, Li Z, Li X, Zhou J, Cao K, Xiong W, Zeng Z, Li X, Qiu Y, Li G, Zhou M*. Zinc-finger protein YY1 suppresses tumor growth of human nasopharyngeal carcinoma by inactivating c-Myc-mediated microRNA-141 transcription. J Biol Chem. 2019, April, 294(15): 6172-6187

9.       Chunchun Wu^#, Mengna Li^#, Hanbing Meng, Yukun Liu, Weihong Niu, Yao Zhou, Ran Zhao, Yumei Duan, Zhaoyang Zeng, Xiaoling Li, Guiyuan Li, Wei Xiong, Ming Zhou*. Analysis of status and countermeasures of cancer incidence and mortality in China. SCIENCE CHINA Life Sciences. 2019, May, 62(5): 640-647

10.    Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M*. p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53. Cancer Sci. 2019 Mar;110(3): 939-949

11.    Liu Y, Zhao R, Wei Y, Li M, Wang H, Niu W, Zhou Y, Qiu Y, Fan S, Zhan Y, Xiong W, Zhou Y, Li X, Li Z, Li G, Zhou M*. BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141. J Exp Clin Cancer Res. 2018 Mar 20;37(1):64.

12.    Ran Zhao, Yukun Liu, Heran Wang, Jing Yang, Weihong Niu, Songqing Fan, Wei Xiong, Jian Ma, Xiaoling Li, Joshua B. Phillips, Ming Tan, Guiyuan Li and Ming Zhou*. BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-kappa B signaling pathway. Cell Mol Immunol. 2017 Oct;14(10):830-841

13.    Wang H, Zhao R, Guo C, Jiang S, Yang J, Xu Y, Liu Y, Fan L, Xiong W, Ma J, Peng S, Zeng Z, Zhou Y, Li X, Li Z, Li X, Schmitt DC, Tan M, Li G, Zhou M*. Knockout of BRD7 results in impaired spermatogenesis and male infertility. Scientific Reports, 2016 Feb 16; 6: 21776.

14.    Yukun Liu, Ran Zhao, Heran Wang, Yanwei Luo, Xinye Wang, Weihong Niu, Yao Zhou, Qiuyuan Wen, Songqing Fan, Xiayu Li, Wei Xiong, Jian Ma, Xiaoling Li, Ming Tan, Guiyuan Li, Ming Zhou*. miR-141 is involved in BRD7-mediated cell proliferation and tumor formation through suppression of the PTEN/AKT pathway in nasopharyngeal carcinoma. Cell Death Dis, 2016 Mar 24;7: e2156.

15.    Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, Riker AI, Tan M. MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1). J Biol Chem. 2010, 285(28): 21496-507

16.    Zhou M, Zhao Y, Ding Y, Liu H, Liu Z, Fodstad O, Riker AI, Kamarajugadda S, Lu J, Owen LB, Ledoux SP, Tan M. Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol. Mol Cancer. 2010, 9(1): 33.