个人简介
艾可龙
中南大学湘雅药学院药理学系特聘教授，博士生导师，中南大学临床药学研究与转化中心副主任，湖南省杰出青年基金获得者，中国科学院青年创新促进会会员、优秀会员，心血管研究湖南省重点实验室成员,中国药理学会心血管药理专业委员会青年委员会常务委员。近年来在癌症诊断和治疗、心血管修复等领域取得了多项创新成果，发表SCI论文61篇，以一作或通讯作者身份发表的论文中影响因子大于10的17篇，大于15的11篇,其中包括在Adv. Mater.（IF=30.849，3篇）、Nano Today (IF=20.722) 、J. Am. Chem. Soc.（IF=15.419，3篇）、Angew. Chem. Int. Ed（IF=15.336，2篇）、Adv. Funct. Mater.（IF=18.808）、Bioactive Materials（IF=14.593，2篇）、Redox Biology（IF=11.799）等国际权威学术期刊上多篇，论文他引>10000次，H-因子为37。相关研究成果多次被 Nature Nanotechnology、Nature Chemistry等作为研究亮点报道。担任20余个国际主要学术期刊审稿人，4个SCI期刊的编委或青年编委成员。申请发明专利10余项，其中6项已获授权。获省部级一等奖2项，二等奖1项。
邮箱：aikelong@csu.edu.cn，欢迎本科生、硕士生、博士生与博士后加入研究团队，要求：做事认真，善于沟通，敢想敢干，执行力强。
研究领域：
1. 氧化应激在心脑血管损伤的机制研究；
2. 纳米药物在癌症诊疗、心脑血管修复的研究。
教育经历：
1. 武汉大学 本科
2. 国科大 硕士
3. 吉林大学 博士
工作经历：
1. 2002.07-2019年10月 中国科学院长春应用化学研究所，历任研究实习员，助理研究员，副研究员
2. 2019.11至今 中南大学湘雅药学院，特聘教授
科研项目：
1. 主持国家自然科学基金面上项目、青年项目、中南大学特聘人才科研启动项目等8项研究课题；
2. 作为核心骨干成员参与科技部国家重点研发计划2项、国家自然科学基金重点项目1项等多个科研课题研究。
奖励和荣誉：
1. 吉林省自然科学一等奖(2018,排名第3）；
2. 吉林省自然科学二等奖(2020,排名第3）；
3. 吉林省自然科学一等奖(2012,排名第8）；
4. 中国科学院青年创新促进会会员（2014）和优秀会员（2019）。
学术兼职
1. 《分析化学》青年编委；
2. 《The Innovation》青年编委；
3. 《Military Medical Research》青年编委；
4. 《Mini-Reviews in Medicinal Chemistry》编委；
5. 中国药理学会心血管药理专业委员会青年委员会常务委员。
团队成员成果（新课题组，硕士从2020年招生、博士从2021年开始招生）
1. 赵天娇，2021级博士，已在课题组发表两篇SCI论文（IF分别为20.722，14.593）
2. 陈立，2020级硕士，已在课题组发表大于11分SCI论文1篇
3. 黄佳，2020级硕士，已在课题组发表大于8分SCI论文1篇
发表论文：
61. Yan Zhu#, Tianjiao Zhao#, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Huang Qiong*, Ai Kelong*. Rheumatoid Arthritis Microenvironment Insights into Treatment Effect of Nanomaterials. Nano Today. 2022; 42, 101358. IF=20.722
60. Zhao Tianjiao#, Wu Wei#, Sui Lihua, Huang Qiong*, Nan Yayun, Liu Jianhua, Ai Kelong*. Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries. Bioactive Materials. 2022; 7, 47-72. IF=14.593
59. Wang Jianling#, Sui Lihua#, Huang Jia, Miao Lu, Nie Yubing, Wang Kuansong, Yang Zhichun, Huang Qiong*, Gong Xue, Nan Yayun, Ai Kelong*. MoS2-based nanocomposites for cancer diagnosis and therapy. Bioactive Materials. 2021; 6(11): 4209-4242. IF=14.593
58. Chen Li#, Huang Qiong#, Zhao Tianjiao, Sui Lihua, Wang Shuya, Xiao Zuoxiu, Nan Yayun, Ai Kelong*. Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19. Redox Biology. 2021; 45: 102046-102046. IF=11.799
57. Li Zelun#, Wang Juan#, Chen Qian, Ai Kelong*, Lu Lehui*. Hierarchically porous polymer with ultra-high affinity for bisphenol A enables high efficient water purification. Science China Chemistry. 2021. IF=9.445
56. Kelong Ai, Jia Huang, Zuoxiu Xiao, Yuqi Yang, Yuwang Bai, Jun Peng*. Localized surface plasmon resonance properties and biomedical applications of copper selenide nanomaterials. Materials Today Chemistry. 2021; 8:100402. IF=8.301
55. Yu Bin, Ai Kelong*, Lu Lehui*. Dual-protective nano-sunscreen enables high-efficient elimination of the self-derived hazards. Applied Materials Today. 2020; 18. IF=10.041
54. Sui Lihua#, Wang Jianling#, Xiao Zuoxiu, Yang Yuqi, Yang Zhichun*, Ai Kelong*. ROS-Scavenging Nanomaterials to Treat Periodontitis. Frontiers in Chemistry. 2020; 8. IF=5.221
53. Li Niansheng, Chen Li, Xiao Zuoxiu, Yang Yuqi, Ai Kelong*. Progress in Detection of Biomarker of Ovarian Cancer: Lysophosphatidic Acid. Chinese Journal of Analytical Chemistry. 2020; 48(12): 1597-1606. IF=1.134
52. Huang Qiong, Wu Wei*, Ai Kelong*, Liu Jianhua. Highly Sensitive Polydiacetylene Ensembles for Biosensing and Bioimaging. Frontiers in Chemistry. 2020; 8. IF=5.221
51. Zhang Lei, Shen Xiangtan, Ai Kelong, Cui Xiaoqiang*, Wang Haoxiang, Zheng Weitao. sp(2) C-Dominant O-Doped Hierarchical Porous Carbon for Supercapacitor Electrodes. ACS Applied Energy Materials. 2019; 2(10): 7009-7018. IF=6.024
50. Wang Juan, Li Zelun, Wang Ying, Wei Changting, Ai Kelong*, Lu Lehui*. Hydrogen bond-mediated strong adsorbent-I3- interactions enable high-efficiency radioiodine capture. Materials Horizons. 2019; 6(7): 1517-1525. IF=13.266
49. Wang Juan, Ai Kelong*, Lu Lehui*. Flame-retardant porous hexagonal boron nitride for safe and effective radioactive iodine capture. Journal of Materials Chemistry A. 2019; 7(28): 16850-16858. IF=12.732
48. Li Zelun, Chang Xuling, Wang Ying, Wei Changting, Wang Juan, Ai Kelong*, Zhang Ye*, Lu Lehui*. Point-and-Shoot Strategy for Identification of Alcoholic Beverages. Analytical Chemistry. 2018; 90(16): 9838-9844. IF=6.986
47. Ai Kelong, Li Zelun, Li Weiwei, Fan Jinchang, Cui Xiaoqiang*, Zheng Weitao. Robust Synthesis of High-Performance N-Graphite Hollow Nanocatalysts Based on the Ostwald Ripening Mechanism for Oxygen Reduction Reaction Electrocatalysis. Particle & Particle Systems Characterization. 2018; 35(10). IF=3.310
46. Wei Changting, Shen Mengxia, Ai Kelong, Lu Lehui. Transformation from FeS/Fe3C nanoparticles encased S, N dual doped carbon nanotubes to nanosheets for enhanced oxygen reduction performance. Carbon. 2017; 123: 135-144. IF=9.594
45. Wang Ying, Pei Hanwen, Jia Yan, Liu Jianhua, Li Zelun, Ai Kelong*, Lu Zhongyuan, Lu Lehui*. Synergistic Tailoring of Electrostatic and Hydrophobic Interactions for Rapid and Specific Recognition of Lysophosphatidic Acid, an Early-Stage Ovarian Cancer Biomarker. Journal of the American Chemical Society. 2017; 139(33): 11616-11621. IF=15.419
44. Shen Mengxia, Wei Changting, Ai Kelong, Lu Lehui. Transition metal-nitrogen-carbon nanostructured catalysts for the oxygen reduction reaction: From mechanistic insights to structural optimization. Nano Research. 2017; 10(5): 1449-1470. IF=8.897
43. Liu Yanlan#, Ai Kelong#, Ji Xiaoyuan, Askhatova Diana, Du Rose, Lu Lehui*, Shi Jinjun*. Comprehensive Insights into the Multi-Antioxidative Mechanisms of Melanin Nanoparticles and Their Application To Protect Brain from Injury in Ischemic Stroke. Journal of the American Chemical Society. 2017; 139(2): 856-862. IF=15.419
42. Li Zelun#, Ai Kelong#, Yang Zhe, Zhang Tianqi, Liu Jianhua, Cui Xiaoqiang*. Untrasmall Bi2S3 nanodots for in vivo X-ray CT imaging-guided photothermal therapy of cancer. RSC Advances. 2017; 7(47): 29672-29678. IF=3.361
41. Li Yuanyuan, Jiang Chunhuan, Zhang Dawei, Wang Ying, Ren Xiaoyan, Ai Kelong, Chen Xuesi*, Lu Lehui*. Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. Acta Biomaterialia. 2017; 47: 124-134. IF=8.947
40. He Wenya, Ai Kelong, Ren Xiaoyan, Wang Shengyan, Lu Lehui*. Inorganic layered ion-exchangers for decontamination of toxic metal ions in aquatic systems. Journal of Materials Chemistry A. 2017; 5(37): 19593-19606. IF=12.732
39. He Wenya, Ai Kelong, Jiang Chunhuan, Li Yuanyuan, Song Xiangfu, Lu Lehui*. Plasmonic titanium nitride nanoparticles for in vivo photoacoustic tomography imaging and photothermal cancer therapy. Biomaterials. 2017; 132: 37-47. IF=12.479
38. Ai Kelong, Li Zelun, Cui Xiaoqiang*. Scalable preparation of sized-controlled Co-N-C electrocatalyst for efficient oxygen reduction reaction. Journal of Power Sources. 2017; 368: 46-56. IF=9.127
37. Wang Ying, Jiang Chunhuan, He Wenhui, Ai Kelong, Ren Xiaoyan, Liu Lin, Zhang Mengchao, Lu Lehui*. Targeted Imaging of Damaged Bone in Vivo with Gemstone Spectral Computed Tomography. ACS Nano. 2016; 10(4): 4164-4172. IF=15.881
36. Ruan Changping, Ai Kelong, Lu Lehui. An Acid-resistant Magnetic Co/C Nanocomposite for Adsorption and Separation of Organic Contaminants from Water. Chinese Journal of Analytical Chemistry. 2016; 44(2): 224-230. IF=1.134
35. Ruan Changping, Shen Mengxia, Ren Xiaoyan, Ai Kelong*, Lu Lehui*. A Versatile and Scalable Approach toward Robust Superhydrophobic Porous Materials with Excellent Absorbency and Flame Retardancy. Scientific Reports. 2016; 6. IF=4.379
34. Chen Yan, Ai Kelong, Liu Jianhua, Ren Xiaoyan, Jiang Chunhuan, Lu Lehui*. Polydopamine-based coordination nanocomplex for T-1/T-2 dual mode magnetic resonance imaging-guided chemo-photothermal synergistic therapy. Biomaterials. 2016; 77: 198-206. IF=12.479
33. Ai Kelong, Ruan Changping, Shen Mengxia, Lu Lehui*. MoS2 Nanosheets with Widened Interlayer Spacing for High-Efficiency Removal of Mercury in Aquatic Systems. Advanced Functional Materials. 2016; 26(30): 5542-5549. IF=18.808
32. Shen Mengxia, Zheng Li-Rong, He Wenhui, Ruan Changping, Jiang Chunhuan, Ai Kelong*, Lu Lehui*. High-performance oxygen reduction electrocatalysts derived from uniform cobalt-adenine assemblies. Nano Energy. 2015; 17: 120-130. IF=17.881
31. Shen Mengxia, Ruan Changping, Chen Yan, Jiang Chunhuan, Ai Kelong*, Lu Lehui*. Covalent Entrapment of Cobalt-Iron Sulfides in N-Doped Mesoporous Carbon: Extraordinary Bifunctional Electrocatalysts for Oxygen Reduction and Evolution Reactions. ACS Applied Materials & Interfaces. 2015; 7(2): 1207-1218. IF=9.229
30. He Wenya, Ai Kelong*, Lu Lehui. Nanoparticulate X-ray CT contrast agents. Science China-Chemistry. 2015; 58(5): 753-760. IF=9.445
29. Chen Yan, Ai Kelong, Liu Jianhua, Sun Guoying, Yin Qi, Lu Lehui*. Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging. Biomaterials 2015; 60: 111-120. IF=12.479
28. Yin Pingping, Ai Kelong, Li Meili, Sun Guoying*. Highly Fluorescent Carbon Nanoparticles for Sensitive Detection of Iron (III). Chinese Journal of Analytical Chemistry. 2014; 42(10): 1427-1433. IF=1.134
27. Ruan Changping, Ai Kelong, Lu Lehui*. Biomass-derived carbon materials for high-performance supercapacitor electrodes. RSC Advances. 2014; 4(58): 30887-30895. IF=3.361
26. Ruan Changping#, Ai Kelong#, Li Xingbo, Lu Lehui*. A Superhydrophobic Sponge with Excellent Absorbency and Flame Retardancy. Angewandte Chemie-International Edition. 2014; 53(22): 5556-5560. IF=15.336
25. Liu Yanlan, Liu Jianhua, Ai Kelong, Yuan Qinghai, Lu Lehui*. Recent advances in ytterbium-based contrast agents for in vivo X-ray computed tomography imaging: promises and prospects. Contrast Media & Molecular Imaging. 2014; 9(1): 26-36. IF=3.161
24. Liu Yanlan, Ai Kelong, Lu Lehui*. Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields. Chemical Reviews. 2014; 114(9): 5057-5115. IF=60.622
23. Chen Yan, Ai Kelong, Liu Yanlan, Lu Lehui*. Tailor-Made Charge-Conversional Nanocomposite for pH-Responsive Drug Delivery and Cell Imaging. ACS Applied Materials & Interfaces. 2014; 6(1): 655-663. IF=9.229
22. Liu Yanlan#, Ai Kelong#, Liu Jianhua, Deng Mo, He Yangyang, Lu Lehui*. Dopamine-Melanin Colloidal Nanospheres: An Efficient Near-Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy. Advanced Materials. 2013; 25(9): 1353-1359. IF=30.849
21. Li Meili, Sun Guoying*, Yin Pingping, Ruan Changping, Ai Kelong*. Controlling the Formation of Rodlike V2O5 Nanocrystals on Reduced Graphene Oxide for High-Performance Supercapacitors. ACS Applied Materials & Interfaces. 2013; 5(21): 11462-11470. IF=9.229
20. Ai Kelong#, Liu Yanlan#, Ruan Changping, Lu Lehui*, Lu Gaoqing*. Sp2 C-Dominant N-Doped Carbon Sub-micrometer Spheres with a Tunable Size: A Versatile Platform for Highly Efficient Oxygen-Reduction Catalysts. Advanced Materials. 2013; 25(7): 998-1003. IF=30.849
19. Liu Yanlan, Ai Kelong, Lu Lehui*. Nanoparticulate X-ray Computed Tomography Contrast Agents: From Design Validation to in Vivo Applications. Accounts of Chemical Research. 2012; 45(10): 1817-1827. IF=22.384
18. Liu Yanlan, Ai Kelong, Liu Jianhua, Yuan Qinghai, He Yangyang, Lu Lehui*. A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging. Angewandte Chemie-International Edition. 2012; 51(6): 1437-1442. IF=15.336
17. Liu Yanlan, Ai Kelong, Liu Jianhua, Yuan Qinghai, He Yangyang, Lu Lehui*. Hybrid BaYbF5 Nanoparticles: Novel Binary Contrast Agent for High-Resolution in Vivo X-ray Computed Tomography Angiography. Advanced Healthcare Materials. 2012; 1(4): 461-466. IF=9.933
16. Liu Xiaojuan, Zong Chenghua, Ai Kelong, He Wenhui, Lu Lehui*. Engineering Natural Materials as Surface-Enhanced Raman Spectroscopy Substrates for In situ Molecular Sensing. ACS Applied Materials & Interfaces. 2012; 4(12): 6599-6608. IF=9.229
15. Zong Chenghua, Ai Kelong, Zhang Guo, Li Hongwei, Lu Lehui*. Dual-Emission Fluorescent Silica Nanoparticle-Based Probe for Ultrasensitive Detection of Cu2+. Analytical Chemistry. 2011; 83(8): 3126-3132. IF=1.134
14. Sun Hongmei, Yuan Qinghai, Zhang Baohua, Ai Kelong, Zhang Pengguo, Lu Lehui*. Gd-III functionalized gold nanorods for multimodal imaging applications. Nanoscale. 2011; 3(5): 1990-1996. IF=7.790
13. Liu Yanlan, Ai Kelong, Yuan Qinghai, Lu Lehui*. Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging. Biomaterials. 2011; 32(4): 1185-1192. IF=12.479
12. Liu Yanlan, Ai Kelong, Lu Lehui*. Designing lanthanide-doped nanocrystals with both up- and down-conversion luminescence for anti-counterfeiting. Nanoscale. 2011; 3(11): 4804-4810. IF=7.790
11. Liu Xiaojuan, Cao Linyuan, Song Wei, Ai Kelong, Lu Lehui*. Functionalizing Metal Nanostructured Film with Graphene Oxide for Ultrasensitive Detection of Aromatic Molecules by Surface-Enhanced Raman Spectroscopy. ACS Applied Materials & Interfaces. 2011; 3(8): 2944-2952. IF=9.229
10. Li Hong-Wei, Ai Kelong, Wu Yuqing*. Fluorescence visual gel-separation of dansylated BSA-protected gold-nanoclusters. Chemical Communications. 2011; 47(35): 9852-9854. IF=6.222
9. Ai Kelong, Liu Yanlan, Lu Lehui*, Cheng Xiaoli, Huo Lihua. A novel strategy for making soluble reduced graphene oxide sheets cheaply by adopting an endogenous reducing agent. Journal of Materials Chemistry. 2011; 21(10): 3365-3370. IF=12.732
8. Ai Kelong, Liu Yanlan, Liu Jianhua, Yuan Qinghai, He Yangyang, Lu Lehui*. Large-Scale Synthesis of Bi2S3 Nanodots as a Contrast Agent for In Vivo X-ray Computed Tomography Imaging. Advanced Materials. 2011; 23(42): 4886-4891. IF=30.849
7. Liu Yanlan, Ai Kelong, Cheng Xiaoli, Huo Lihua, Lu Lehui*. Gold-Nanocluster-Based Fluorescent Sensors for Highly Sensitive and Selective Detection of Cyanide in Water. Advanced Functional Materials. 2010; 20(6): 951-956. IF=18.808
6. Zhao Xinmei, Zhang Baohua, Ai Kelong, Zhang Guo, Cao Linyuan, Liu Xiaojuan, Sun Hongmei, Wang Haishui, Lu Lehui*. Monitoring catalytic degradation of dye molecules on silver-coated ZnO nanowire arrays by surface-enhanced Raman spectroscopy. Journal of Materials Chemistry. 2009; 19(31): 5547-5553. IF=12.732
5. Ai Kelong, Zhang Baohua, Lu Lehui*. Europium-Based Fluorescence Nanoparticle Sensor for Rapid and Ultrasensitive Detection of an Anthrax Biomarker. Angewandte Chemie-International Edition. 2009; 48(2): 304-308. IF=15.336
4. Ai Kelong, Liu Yanlan, Lu Lehui*. Hydrogen-Bonding Recognition-Induced Color Change of Gold Nanoparticles for Visual Detection of Melamine in Raw Milk and Infant Formula. Journal of the American Chemical Society. 2009; 131(27): 9496. IF=15.419
3. Zhang Baohua, Wang Haishui, Lu Lehui*, Ai Kelong, Zhang Guo, Cheng Xiaoli. Large-area silver-coated silicon nanowire arrays for molecular sensing using surface-enhanced Raman spectroscopy. Advanced Functional Materials. 2008; 18(16): 2348-2355. IF=18.808
2. Lu Lehui, Ai Kelong, Ozaki Yukihiro*. Environmentally friendly synthesis of highly monodisperse biocompatible gold nanoparticles with urchin-like shape. Langmuir. 2008; 24(3): 1058-1063. IF=3.882
1. Li Peicai, Zhang Lixue, Ai Kelong, Li Dan, Liu Xiaohua, Wang Erkang*. Coating didodecyldimethylammonium bromide onto Au nanoparticles increases the stability of its complex with DNA. Journal of Controlled Release. 2008; 129(2): 128-134. IF=9.776