Organocatalytic domino sequence to asymmetrically access spirocyclic oxindole-α-methylene-γ-lactams

Release time:2021-07-02

Journal:Tetrahedron

Abstract:An asymmetric allylic alkylation-lactamization domino sequence of 3-aminooxindoles with Morita-Baylis-Hillman carbonates catalyzed by quinidine derivative (β-ICD) was developed. And a series of chiral spirocyclic oxindole-α-methylene-γ-lactams have been facilely prepared in good yields and stereoselectivities. This developed protocol would broaden the utilization of Morita-Baylis-Hillman carbonates in asymmetric construction of spirocyclic oxindoles.

Co-author:Yu Zheng, Yu-Lun Qian

First Author:Zhen-Zhen Xie

Indexed by:Journal paper

Correspondence Author:Kai Chen*, Hua Yang*

Discipline:Natural Science

First-Level Discipline:Chemistry

Volume:89

Page Number:132163

Translation or Not:no

Date of Publication:2021-06-04

Included Journals:SCI