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  • Personal Information


    Supervisor of Doctorate Candidates

    Supervisor of Master's Candidates

    Date of Employment:2002-07-01

    School/Department:Basic Medical Sciences

    Education Level:Postgraduate (Postdoctoral)


    Degree:Doctoral degree


    Alma Mater:中南大学

    Discipline:Basic Medicine

  • Profile


    1. Name: Zhong-Liang Hu


    87 Xiangya Road

    Department of Pathology

    Xiangya Hospital

    Central South University

    Changsha, P.R. China, 410013

    Telephone: 0086-731-84327291(0)

    Mobile Phone: 0086-13973168154

    Fax: 0086-731-84327291

    E-mail address:  

    3. Current Titles and Affiliations:

    A. Associate director of Department of Pathology, Professor of Pathology, doctoral supervisor

    , Department of Pathology, The Xiangya Hospital, Central South University, Changsha, China.

    B. Professor of Pathology, doctoral supervisor, Department of Pathology, Xiangya Medical School, Central South University, Changsha, China.

    4. Previous Academic and Professional Appointments:

      Assistant Professor (2007-2018), Department of Pathology, Xiangya Medical School, Central South University  

    Fellowship (2005-2007), Department of Pathology, Xiangya Hospital, Central South University

    Resident (1997-1999), Department of occupation disease, the Institute   of occupation disease prevent and treatment, Changsha, Hunan 

    5. EDUCTION:

        2011-2013 Postdoctal

           Department of Medical Oncology and hemotology, Emory University, Atlanta, Georgia

      2001-2004: Ph.D. (Pathology and pathophysiology)

      Department of Pathology and Cancer Institute, Xiangya Medical School, Central South University, Changsha, Hunan, China

      1999-2001: M.S. (Pathology)

      Department of Pathology, Xiangya Medical School, Central South University, Changsha, Hunan, China

      1992-1997: M.D. (Medicine)

        Hunan Medical University, Changsha, Hunan, China


       Molecular classification of cancer and calcium-phosphorus metabolism


     7.1National Natural Science Foundation of China: 

    7.1.1 Title:The role of SSTR1 in the regulation of secondary hyperparathyroidism and its mechanism study (81860147).

    Agency: Central South University

    Role: Principal Investigator 

    Period: 01/01/19-12/31/22

          7.1.2 TitleThe role of MAPK-p-smad3L cascade in the expression of Fascin1 induced

    by TGF-β in gastric cancer cells (81072036)

    Agency: Central South University

    Role: Principal Investigator 

    Period: 01/01/11-12/31/11

           7.1.3 Title: Research of Cross-talk between MAPK and NF-κB Cascades Mediated by HCV Proteins30270601

       Agency: Central South University

       Role: Project Co-Leader (Project 8)

       Period: 01/01/02-12/31/05

          7.2 Research Fund for the Doctoral Program of Higher Education of China

    TitleThe role of Fascin1 in the invasion and metastasis of gastric cancer cells induced by TGF-βand its possible mechanism (20060533007)

     Agency: Central South University

     Role: Project Co-Leader (Project 3)

     Period: 01/01/06-12/31/09

          7.3 Research Fund of Institute of Health of Hunan Province

    TitleThe effects of Ras-ERK signaling pathway in the expression of Fascin in

        gastric cancer cell

     Agency: Central South University

     Role: Principal Investigator

     Period: 01/01/11-12/31/12

    8. Articles Published in Recent Years

    1. Tong K., Hu Z. FOXI1 expression in chromophobe renal cell carcinoma and renal oncocytoma: a study of The Cancer Genome Atlas transcriptomebased outlier mining and immunohistochemistry. Virchows Arch. 2021 Apr;478(4):647-658.

    2. Tong K, Zhu W, Fu H, Cao F, Wang S, Zhou W, Liu C, Chen D,  Fan S, Hu Z. Frequent KRAS Mutations in Oncocytic Papillary Renal Neoplasm with Inverted Nuclei. Histopathology. 2020 Jun;76(7):1071-1083.

    3. Luo X, He Y, Tang H, Cao Y, Gao M, Liu B, Hu Z. Effects of HER2 on the invasion and migration of gastric cancer. Am J Transl Res. 2019 Dec 15;11(12):7604-7613.

    4. Zou H, Duan Y, Wei D, Zhang Y, Dai J, Li J, Li X, Zhou J, Liu Z, Jin Z, Zhang Z, Yu Y, Hu Z. Molecular features of pleomorphic xanthoastrocytoma. Hum Pathol. April 2019, 86:38-48.

    5. Qian G, Wang D, Magliocca KR, Hu Z, Nannapaneni S, Kim S, Chen Z, Sun SY, Shin DM, Saba NF, Chen ZG. Human papillomavirus oncoprotein E6 upregulates c-Met through p53 downregulation. Eur J Cancer. 2016 Sep;65:21-32.

    6. Zhang C, Liu S, Yuan X, Hu Z, Li H, Wu M, Yuan J, Zhao Z, Su J, Wang X, LiaoY, Liu Q. Valproic Acid Promotes Human Glioma U87 Cells Apoptosis and Inhibits Glycogen Synthase Kinase-3β Through ERK/Akt Signaling. Cell Physiol Biochem. 2016;39(6):2173-2185.

    7. Qian G, Hu Z, Xu H, Müller S, Wang D, Zhang H, Kim S, Chen Z, Saba NF, Shin DM, Wang AY, Chen ZG. A novel prediction model for human papillomavirus-associated oropharyngeal squamous cell carcinoma using p16 and subcellular β-catenin expression. J Oral Pathol Med. 2016 Jul;45(6):399-408.

    8. Hu Z, Qian G, Müller S, Xu J, Saba NF, Kim S, Chen Z, Jiang N, Wang D, Zhang H, Lane K, Hoyt C, Shin DM, Chen ZG. Biomarker quantification by multiplexed quantum dot technology for predicting lymph node metastasis and prognosis in head and neck cancer. Oncotarget. 2016 Jul 12;7(28):44676-44685.

    9. Hu Z, Müller S, Qian G, Xu J, Kim S, Chen Z, Jiang N, Wang D, Zhang H, Saba NF, Shin DM, Chen ZG. Human papillomavirus 16 oncoprotein regulates the translocation of β-catenin via the activation of epidermal growth factor receptor. Cancer. 2015 Jan 15;121(2):214-25.

    10. Li L, Cao F, Liu B, Luo X, Ma X, Hu Z. TGF-β induces fascin expression in gastric cancer via phosphorylation of smad3 linker area. Am J Cancer Res. 2015 May 15;5(6):1890-6.

    11. Wang D, Fei B, Halig LV, Qin X, Hu Z, Xu H, Wang YA, Chen Z, Kim S, Shin DM, Chen ZG. Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer. ACS Nano. 2014 Jul 22;8(7):6620-32.

    12. Jiang N, Wang D, Hu Z, Shin HJ, Qian G, Rahman MA, Zhang H, Amin AR, Nannapaneni S, Wang X, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, Ma J, Chen ZG, Saba NF. Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma. Mol Cancer Ther. 2014 Jul;13(7):1826-36.

    13. Zhou H, Wang K, Hu Z, Wen J. TGF-β1 alters microRNA profile in human gastric cancer cells. Chin J Cancer Res. 2013 Feb;25(1):102-11. 

    14. Li R, You S, Hu Z, Chen ZG, Sica GL, Khuri FR, Curran WJ, Shin DM, Deng X. Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer. PLoS One. 2013 Sep 3;8(9):e74670.

    15. Li R, Hu Z, Sun SY, Chen ZG, Owonikoko TK, Sica GL, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12.

    16. Wang D, Müller S, Amin AR, Huang D, Su L, Hu Z, Rahman MA, Nannapaneni S,  Koenig L, Chen Z, Tighiouart M, Shin DM, Chen ZG*. The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma. Clin Cancer Res. 2012, 18(17):4589-99.

    17. Hu Z, Lü H, Yin HL, Wen JF, Jin O. A case of mesothelial/monocytic incidental cardiac excrescence and literature review. Diagn Pathol. 2010;5: 40.

    18. Hu Z, Wang X, Wen JF, Zhang RQ. TGIF antagonizes the apoptosis of gastric cancer cells induced by TGF-β. Chinese Journal of General Surgery. 2010,19(4): 379-382.

    19. Fu H, Hu Z (co-first author), Wen J, Wang K, Liu Y. TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways. Acta Biochim Biophys Sin. 2009 Aug; 41(8):648-56.

    20. Fu H, Wen JF, Hu Z, Luo GQ, Ren HZ. Knockdown of fascin1 expression suppresses the proliferation and metastasis of gastric cancer cells. Pathology. 2009; 41(7):655-60.

    21. Xiao DS, Wen JF, Li JH, Wang KS, Hu Z, Zhou JH, Deng ZH, Liu Y. Effect of DPC4 Gene on Invasion and Metastasis of Colorectal Carcinoma Cells. Acta Biochim Biophys Sin (Shanghai). 2006 Dec 15;38(12):883-892.

    22. Wang KS, Hu Z, Li JH, Xiao DS, Wen JF. Enhancement of metastatic and invasive capacity of gastric cancer cells by transforming growth factor-beta1.Acta Biochim Biophys Sin (Shanghai). 2006 Mar;38(3):179-86. 

    23. Hu Z, Wen JF, Shen M, Liu Y. Expressions of TGIF, MMP9 and VEGF proteins and their clinicopathological relationship in gastric cancer. Journal of Central South University (Medical Sciences). 2006 Feb;31(1): 70-4.

    24. Hu Z, Wen JF, XiaoDS, Zheng H, Fu CY. Effects of TGIF on growth and metastasis of gastric carcinoma cells. Progress in Biochemistry and Biophysics. 2005, 32(9):865-870.

    25. Hu Z, Wen JF, XiaoDS, Zheng H, Fu CY. Effects of transforming growth interacting factor on biological behaviors of gastric carcinoma cells. World Journal of Gastroenterology. 2005 Jan 7; 11 (1):84-8.

    26. He RF, Hu Z, Wen JF. Biological implication of PTEN gene expression in human gastric cancer and related molecular mechanisms. Zhonghua Bing Li Xue Za Zhi. 2007 May; 36(5):324-8.

    27. Li B, Feng DY, Cheng RX, He QQ, Hu Z, Zheng H, Wen JF. Effects of Hepatitis C virus (HCV) core protein on hepatocyte derived from human. Chinese Medical Journal. 2005, 85(18)1243-1248.

    28. Xiao DS, Wen JF, Li JH, Hu Z, Zheng H, Fu CY. Effect of deleted pancreatic cancer locus 4 gene transfection on biological behaviors of human colorectal carcinoma cells. World Journal of Gastroenterology. 2005 Jan 21;11 (3):348-52.

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  • Work Experience

    [1]  2002.6- 2021.10
    中南大学 | 基础医学院
    [2]  2017.9- 2019.1
    新疆医科大学 | 基础医学院 | 援疆副院长
    [3]  2011.6- 2013.6
    美国Emory大学 | 血液学和医学肿瘤学系 | 博士后
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