刘琦

个人简介

刘琦，男，博士，副教授，博士研究生导师。2015年6月于中南大学分析化学专业博士毕业，获理学博士学位；2015年11月至2017年12月在中国科学院上海应用物理研究所从事博士后研究；2018年4月至今在中南大学化学化工学院任教。主要从事生物复杂体系分离分析、疾病早期诊断、环境与食品安全智能检测及纳米DNA生物传感器等方面的研究。主持国家自然科学基金青年/面上项目、国家重点研发计划子课题、中南大学创新驱动、湖南省自然科学青年/面上基金项目、长沙市自然科学基金、中国博士后科学基金项目等，以第一作者或通讯作者在Angew. Chem. Int. Ed., Environ. Sci. Technol., Anal. Chem.,  等国际权威刊物上发表SCI收录论文100余篇，引用2700+次，H-index=29，授权国家发明专利5项，2020年获湖南省自然科学二等奖1项(排名第3)。
发表论文：

2025：

[1] In situ SERS monitoring and heterogeneous catalysis verification of Pd-catalyzed Suzuki-Miyaura reaction via bifunctional black raspberry-like plasmonic nanoreactors, Anal.Chem., 2025, 97(10), 5445–5453

[2] Dual-Nanozyme Cascade for System-wide Specific Colorimetric Detection of Aminoglycoside Antibiotics, Anal.Chem., 2025, 97(11), 6136–6144

[3] Cell Response to Nanoplastics and Their Carrier Effects Tracked Real-Timely with Machine Learning-Driven Smart Surface-Enhanced Raman Spectroscopy Slides, Anal.Chem., 2025, 10.1021/acs.analchem.5c00504

2024：

[1] Machine learning-assisted "shrink-restricted" SERS strategy for classification of environmental nanoplastics-induced cell death, Environ. Sci. Technol., 2024, 58, 22528-22538

[2] An Endogenous mRNA-powered and Spatial Confinement-derived DNA Nanomachine for Ultra-rapid and Sensitive Imaging of Let-7a, Anal. Chem., 2024, 96, 564-571

[3] Au/Pt@ZIF-90 Nanoenzyme Capsule based "Explosive" Signal Amplifier for "All-in-Tube" POCT, Anal.Chem., 2024, 96, 1362-1370

[4] Hydrogen bonding-induced aggregation of chiral functionalized AuNS@Ag NPs for photothermal enantioanalysis, Anal.Chem., 2024, 96, 6292-6300

[5] Nanoenzyme Hydrogel Film Based Portable Point-of-Care Testing Platform for Double-Signal Visual Detection of PSA, Anal.Chem., 2024, 96, 9909−9916

[6] Synergy of target-induced magnetic network and single-drop chromogenic system for ultrasensitive "All-in-Tube" detection of miRNA in whole blood, Anal.Chem., 2024, 96, 12012−12021

[7] Machine learning-aided 3D dynamic SERS strategy for physiological mapping: biotoxicity of environmentally dimensional aged nanoplastics and corresponding protein corona complexes, Anal.Chem., 2024, 96, 16629−16638

[8] A Stimuli-Responsive Photoluminescent Molecular Tweezer for Highly Enantioselective Discrimination of Chiral Primary Amines, Anal.Chem., 2024, 96, 19632–19640

[9] A Nanocage Reactor with Dense Shareable Hot Spots for in-situ and Dynamic SERS Tracking Photocatalytic Reaction Bonds Variations Chem. Eng. J. 2024, 489, 151358

[10] Interfacially crystallized Enzyme@MOFs biocatalytic membranes for highly efficient synthesis of D-amino acids via continuously recirculating stereoinversion, Chem. Eng. J. 2024, 497, 154529

[11] Tartaric acid-derived chiral carbon nanodots for catalytic enantioselective ring-opening reactions of styrene oxide, Chem. Commun.,  2024, 60, 10382-10385 

[12] Photothermal hydrogel-integrated paper-based point-of-care platform for visible distance-readout of glucose, Anal. Chim. Acta, 2024, 1285, 342035

[13] A novel functionalized CdTe@MOFs based fluorometric and colorimetric biosensor for dual-readout assay of creatinine, Sensor Actuat. B-Chem., 2024, 399, 134842

[14] Mixed-valent Fe-MOF accelerated Fe(III)/Fe(II) cycle for highly efficient photo-Fenton-like catalytic degradation of organic pollutants: Boosting mechanism and degradation pathways, J. Environ. Chem. Eng., 2024, 12(5), 113577

2023：

[1] Pore Size Tunable Trypsin@ZIF-90 and Hydrogel Integrated Lateral Flow Point-of-Care Platform for ATP Detection, ACS Appl. Mater. Interfaces, 2023, 15, 17, 21690–21698

[2] Self-propelled quantum dots-based spherical nucleic amplifier for ratiometric imaging of intracellular microRNAs, Sensor. Actuat. B-Chem., 2023, 374, 132802

[3] Cu2+ assisted carnation-like fluorescent metal–organic framework for triple-mode detection of glyphosate in food samples, Food Chem., 2023, 408, 135237

[4] Dual-ligand lanthanide metal-organic framework probe for ratiometric fluorescence detection of mercury ions in wastewater, Microchim. Act, 2023, 190(9), 1-11

2022：

[1] Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells, Anal. Chem., 2022, 94(6), 2934-2941

[2] Facile construction of a reusable multi-enzyme cascade bioreactor for effective fluorescence discrimination and quantitation of amino acid enantiomers, Chem. Eng. J., 2022, 428, 131975

2021：

[1] AIEgen modulated per-functionalized flower-like IRMOF-3 frameworks with tunable light emission and excellent sensing properties, Chem. Commun., 2021, 57, 2392-2395

[2] Framework nucleic acid programmed combinatorial delivery nanocarriers for parallel and multiplexed analysis, Chem. Commun., 2021, 57, 10935-10938

[3] Integrating amino acid oxidase with photoresponsive probe A fast quantitative readout platform of amino acid enantiomers, Talanta, 2021, 224, 121894 

[4] High quantum-yield carbon dots embedded metal-organic frameworks for selective and sensitive detection of dopamine, Microchem. J., 2021, 160, 105718

[5] Simultaneous In Situ Extraction and Self-Assembly of Plasmonic Colloidal Gold Superparticles for SERS Detection of Organochlorine Pesticides in Water, Anal. Chem.,  2021, 93(10), 4657-4665

2020:

[1] Integrating Target-Triggered Aptamer Capped HRP@Metal−Organic Frameworks with Colorimeter Readout for On-site Sensitive Detection of Antibiotics, Anal. Chem., 2020, 92(20), 14259-14266.

[2] AIE-active metal–organic frameworks facile preparation, tunable light emission, ultrasensitive sensing of copper(II) and visual fluorescence detection of glucose, J. Mater. Chem. C, 2020, 8(30), 10408-10415.

[3] L-Pyroglutamic Acid-Modified CdSe/ZnS Quantum Dots: A New Fluorescence-Responsive Chiral Sensing Platform for Stereospecific Molecular Recognition, Anal. Chem., 2020, 92(17), 12040-12048.

2019-:

[1] Valency-Controlled Framework Nucleic Acid Signal Amplifiers, Angew. Chem. Int. Ed., 2018, 57, 7131-7135

[2] Facile green and one-pot synthesis of purple perilla derived carbon quantum, Talanta, 2019, 201, 1-8

[3] Single-stranded DNA modified protonated graphitic carbon nitride nanosheets A versatile ratiometric fluorescence platform for multiplex detection of various targets, Talanta, 2019, 197, 422-430

科技奖励：

[1] 2019年湖南省自然科学奖二等奖：食源生物小分子分离分析及构效关系研究 (排名第3)

主持科研项目：
[1] 国家自然科学基金青年项目，基于功能化高阶框架核酸的前列腺肿瘤多标志物联合检测研究

[2] 国家自然科学基金面上项目，荧光编码多通道快检分子分类器及其前列腺癌精准诊断研究

[3] 中国博士后科学基金第60批面上资助，DNA 纳米结构及其复合物的构建、纯化及生物检测应用
[4] 湖南省自然科学基金青年项目，基于CCC-LC 全二维色谱的β-分泌酶抑制剂快速识别研究

[5] 中南大学创新驱动项目，基于框架化学的传感设计与应用

[6] 湖南省自然科学基金面上项目，基于框架核酸靶向功能纳米探针的前列腺癌诊疗一体化研究

[7] 长沙市自然科学基金，长沙市湘江水系新污染物高效筛查技术研究

[8] 中南大学科学研究启动基金，联用色谱体系构建及应用

[9] 食品安全监测与预警湖南省重点实验室2020年度开放基金课题

招生专业：分析化学、生物与医药

教育经历

[1]   2009.9-2015.5

中南大学  |  分析化学  |  博士学位  |  博士研究生毕业
硕博连读

[2]   2005.9-2009.6

中南大学  |  制药工程  |  学士学位  |  大学本科毕业

工作经历

[1]   2020.9-至今

中南大学  |  副教授  |  在岗

[2]   2018.4-2020.9

中南大学  |  化学化工学院  |  讲师

[3]   2015.11-2017.12

中国科学院上海应用物理研究所  |  助理研究员

研究方向

[1]  DNA纳米技术及疾病靶标传感检测：Angew. Chem. Int. Ed. 2018, 57, 7131-7135. Anal. Chem., 2024, 96, 564-571. Anal. Chem., 2022, 94(6), 2934-2941. Anal.Chem., 2024, acs.analchem.4c02045.

[2]  环境与食品安全智能检测及POCT：Anal.Chem., 2024, 96, 1362-1370. Anal.Chem., 2024, 96, 6292-6300. Anal.Chem., 2024, 96, 9909？9916. Anal. Chem., 2020, 92(20), 14259-14266.

[3]  纳米生物反应器构建及反应监测：Chem. Eng. J. 2024, 489, 151358. Chem. Eng. J., 2022, 428, 131975. ACS Appl. Mater. Interfaces, 2023, 15, 17, 21690–21698.

其他联系方式

[1]  邮箱： 2eecf1f5601b72d210347895bc30e17971fee315e52d9f34efa90391ca5e880ac9df11d3786b2e7d9aafabbbc63789444f7ff16c8dff4764a813af752150830e185b27cc658ceb2cfd630d3846216856508535a9bd9ec3c4182c9d009c87cee96828a9c848116a84b46c5cb6cf48915e14ae22bd1697531b9029c7fb9833b1e0

[4]  通讯/办公地址： a96669e19de1bb6156426f1eaface3c451c769877cfd606bc7e8c33a262048af82c2e23080b13486c26975625d1f40a94431ddd0f2e80f4a8acc28be8d4e9f4bf5e01e1cfedb486326482311e621af46237b09afc5c7379134cd6df4cda9c19526cc1c5eddffce46891a83bc7c6d01f6a84ed93156a43598491c5393802f1d71