Supervisor of Master's Candidates
Date of Employment:2021-05-08
School/Department:School of Basic Medical Sciences
Education Level:PhD Graduate
Sex:Female
Degree:Doctoral Degree in Medicine
Status:Employed
Alma Mater:中南大学
冷丽智，生殖医学博士，副教授，硕士生导师，湖南省杰青，湖湘青年英才支持计划获得者，长沙市科协第十三次代表大会代表。长期从事人类早期胚胎发育相关研究，通过单细胞组学方法研究正常胚胎的发育机制及异常胚胎的病理机制。作为课题骨干参与国家重点研发计划，主持国家自然科学基金青年项目、湖南省自然科学基金青年项目、中国博士后科学基金特别资助和面上项目；以第一作者（含共同）在Cell Stem Cell、 Nat Commun、Hum Reprod等专业杂志发表SCI论文；申请发明专利2项；参加欧洲生殖年会、中华医学会生殖医学年会、国际基因组学大会等会议并作口头报告。
公开发表论文：
（1) Xiaorui Zhang#, Changquan Zhang#, Di Zhou, Tianlei Zhang, Xueqin Chen, Jinlin Ren, Caixia He, Fei Meng, Qinwei Zhou, Qiaohui Yang, Congling Dai, Ge Lin*, Sicong Zeng*, Lizhi Leng*，Telomeres cooperate in zygotic genome activation by affecting DUX4/Dux transcription. iScience. 2023 Feb 8;26(3):106158.
（2） Leng L#, Sun J#, Huang J#, Gong F, Yang Y, Zhang S, Yuan X, Fang F, Xu X, Luo Y, Bolund L, Peters B, Lu G, Jiang T*, Xu F*, Lin G*. Single-cell transcriptome analysis of uniparental embryos reveals parent-of-origin effects on human preimplantation development. Cell Stem Cell, 2019 Oct 3.
（3） Liu L#, Leng L#, Liu C#, Lu C#, Yuan Y#, Wu L, Gong F, Zhang S, Wei X, Wang M, Zhao L, Hu L, Wang J, Yang H, Zhu S, Chen F, Lu G, Shang Z*, Lin G*. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos. Nat Commun. 2019 Jan 21;10(1):364
（4） Leng L#, Ouyang Q#, Kong X#, Gong F, Lu C, Zhao L, Shi Y, Cheng D, Hu L, Lu G, Lin G*. Self-diploidization of human haploid parthenogenetic embryos through the Rho pathway regulates endomitosis and failed cytokinesis. Sci Rep. 2017 Jun 26;7(1):4242
（5） Dai J#, Leng LZ#, Lu CF, Gong F, Zhang SP, Zheng W, Lu GX, Lin G*. Time-lapse observation and transcriptome analysis of a case with repeated multiple pronuclei after IVF/ICSI. J Assist Reprod Genet. 2017 Sep;34(9):1189-1197
（6） Leng L, Tan Y, Gong F, Hu L, Ouyang Q, Zhao Y, Lu G, Lin G*. Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency. Hum Reprod. 2015 Mar;30(3):737-48
（7） Chenxi Zhang#, Conghui Li#, Ling Yang#, Lizhi Leng#, Dragomirka Jovic, Jun Wang, Fang Fang, Guibo Li, Depeng Zhao, Xuemei Li, Lin Lin, Yonglun Luo, Lars Bolund, Jinrong Huang*, Ge Lin*, Fengping Xu*. The Dynamic Changes of Transcription Factors During the Development Processes of Human Biparental and Uniparental Embryos. Front Cell Dev Biol. 2021 Sep 17;9:709498.
