中南大学李园园

李园园(RICU亚专科主任)

学位：博士学位
职称：主任医师
学科：临床医学
所在单位：湘雅医院

主任医师博士生导师硕士生导师

入职时间：2010-07-15
所在单位：湘雅医院
职务：RICU亚专科主任
学历：博士研究生毕业
办公地点：湘雅医院
性别：女
联系方式：备用邮箱：leeround@163.com
学位：博士学位
毕业院校：中南大学

学科：临床医学

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Discovery of tumor immune infiltration-related snoRNAs for predicting tumor immune microenvironment status and prognosis in lung adenocarcinoma

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发表刊物：

Computational and Structural Biotechnology Journal

摘要：

Lung adenocarcinoma (LUAD) has a high mortality rate and is difficult to diagnose and treat in its early stage. Previous studies have demonstrated that small nucleolar RNAs (snoRNAs) play a critical role in tumor immune infiltration and the development of a variety of solid tumors. However, there have been no studies on the correlation between tumor-infiltrating immune-related snoRNAs (TIISRs) and LUAD. In this study, we filtered six immune-related snoRNAs based on the tissue specificity index (TSI) and expression profile of all snoRNAs between all LUAD cell lines from the Cancer Cell Line Encyclopedia and 21 types of immune cells from the Gene Expression Omnibus database. Further, we performed real-time quantitative polymerase chain reaction (RT-qPCR) to validate the expression status of these snoRNAs on peripheral blood mononuclear cells (PBMCs) and lung cancer cell lines. Next, we developed a TIISR signature based on the expression profiles of snoRNAs from 479 LUAD patients filtered by the random survival forest algorithm. We then analyzed the value of this TIISR signature (TIISR risk score) for assessing tumor immune infiltration, immune checkpoint inhibitor (ICI) treatment response, and the prognosis of LUAD between groups with high and low TIISR risk score. Further, we found that the TIISR risk score groups showed significant differences in biological characteristics and that the risk score could be used to assess the level of tumor immune cell infiltration, thereby predicting prognosis and responsiveness to immunotherapy in LUAD patients. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.

是否译文：

否

收录刊物：

SCI

上一条： N6-methyladenosine (m6A) regulator expression pattern correlates with the immune landscape in lung adenocarcinoma

下一条： Metagenomic Next-Generation Sequencing for the Diagnosis of Pneumocystis jirovecii Pneumonia in Non-HIV-Infected Patients: A Retrospective Study

个人简介

李园园，医学博士，中南大学湘雅医院呼吸与危重症学科主任医师，感染学组组长，呼吸重症监护专科主任，副教授，硕士生/博士生/博士后导师。从事呼吸危重症、重症和难治性感染、支气管哮喘的诊治，呼吸介入和治疗，临床工作中具备对呼吸疾病与内科危重症的熟练诊断和救治能力以及支气管镜操作能力。基础研究方向为哮喘的发病机制，临床研究方向为肺部的病原学诊断、耐药菌诊治，呼吸危重症的综合救治体系的建立与实践。

学术任职：中华医学会呼吸病学分会青年学组委员、感染组学委员，中国医师协会呼吸医师分会青年工作委员会委员、内镜分会呼吸内镜青年常务委员，中国抗癌协会肿瘤呼吸病学专业委员会委员，湖南省卫健委高层次人才医学学科青年骨干人才，湖南省卫健委疾控处呼吸疾病防治办公室副主任，湖南省预防医学会呼吸病预防与控制专业委员会副主任委员，湖南省防痨协会理事会副理事长，《中国感染控制杂志》常务编委，《Infectious Medicine》青年编委。

学术成果：主持国家自然科学基金项目2项、省级课题3项，参与并担任多项全国多中心临床研究项目PI。以第一作者或通讯作者发表SCI论文24篇（JCR1区9篇，其中European Respiratory Journal共一1篇，IF=34）。获得湖南省科技进步奖3次、中南大学湘雅医院医疗新技术成果奖多次，多次在国际国内学术会议上做专题报告与壁报交流。

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