中南大学李园园

李园园(RICU亚专科主任)

学位：博士学位
职称：主任医师
学科：临床医学
所在单位：湘雅医院

主任医师博士生导师硕士生导师

入职时间：2010-07-15
所在单位：湘雅医院
职务：RICU亚专科主任
学历：博士研究生毕业
办公地点：湘雅医院
性别：女
联系方式：备用邮箱：leeround@163.com
学位：博士学位
毕业院校：中南大学

学科：临床医学

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Neutrophil Extracellular Trapping Network Promotes the Pathogenesis of Neutrophil associated Asthma through Macrophages

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IMMUNOLOGICAL INVESTIGATIONS

摘要：

Asthma is a complex airway inflammatory disease that can be roughly classified into eosinophilic phenotype and non-eosinophilic phenotype. Most of the latter manifested as airway inflammation dominated by neutrophil infiltration, namely neutrophil-dominated asthma (NA). Neutrophil extracellular trapping (NETs) is a newly discovered antimicrobial mechanism of neutrophils; however, NETs can not only resist killing pathogenic microorganisms, but also promote tissue damage and autoimmune response. In the present study, we successfully established NA model in C57BL/6 mice and observed the increased formation of NETs. In NA mice, the free DNA abundance, the airway resistance, the cell numbers (total cell number, macrophage number, and neutrophil number), and inflammatory cytokine levels were significantly increased while the lung dynamic compliance was significantly reduced. After DNase I treatment, the above indexes in NA mice were all improved. In NA mice, either treatment with macrophage scavenger or IL-1 beta neutralizing antibody also improved the above-described indexes. In vitro, in human peripheral blood-derived neutrophils, PMA treatment significantly increased the formation of NETs. Furthermore, in macrophages differentiated from THP-1 monocytes, LPS or isolated NETs both significantly increased the levels of cytokines. In conclusion, NETs can stimulate macrophages to secrete IL-1 beta, which promotes neutrophils infiltration in the airway; infiltrated neutrophils, in turn, generates NETs, which can amplify the tissue damage caused by NETs and macrophages, inducing and aggravating NA.

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上一条： Neutrophil extracellular traps amplify neutrophil recruitment and inflammation in neutrophilic asthma by stimulating the airway epithelial cells to activate the TLR4/ NF-κB pathway and secrete chemokines

下一条： Comparison of Clinical, Laboratory and Radiological Characteristics Between COVID-19 and Adenovirus Pneumonia: A Retrospective Study

个人简介

李园园，医学博士，中南大学湘雅医院呼吸与危重症学科主任医师，感染学组组长，呼吸重症监护专科主任，副教授，硕士生/博士生/博士后导师。从事呼吸危重症、重症和难治性感染、支气管哮喘的诊治，呼吸介入和治疗，临床工作中具备对呼吸疾病与内科危重症的熟练诊断和救治能力以及支气管镜操作能力。基础研究方向为哮喘的发病机制，临床研究方向为肺部的病原学诊断、耐药菌诊治，呼吸危重症的综合救治体系的建立与实践。

学术任职：中华医学会呼吸病学分会青年学组委员、感染组学委员，中国医师协会呼吸医师分会青年工作委员会委员、内镜分会呼吸内镜青年常务委员，中国抗癌协会肿瘤呼吸病学专业委员会委员，湖南省卫健委高层次人才医学学科青年骨干人才，湖南省卫健委疾控处呼吸疾病防治办公室副主任，湖南省预防医学会呼吸病预防与控制专业委员会副主任委员，湖南省防痨协会理事会副理事长，《中国感染控制杂志》常务编委，《Infectious Medicine》青年编委。

学术成果：主持国家自然科学基金项目2项、省级课题3项，参与并担任多项全国多中心临床研究项目PI。以第一作者或通讯作者发表SCI论文24篇（JCR1区9篇，其中European Respiratory Journal共一1篇，IF=34）。获得湖南省科技进步奖3次、中南大学湘雅医院医疗新技术成果奖多次，多次在国际国内学术会议上做专题报告与壁报交流。

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