Impact Factor:1.92
DOI number:10.1002/rcm.8112
Journal:Rapid Communications in Mass Spectrometry
Key Words:DESORPTION ELECTROSPRAY-IONIZATION, ON-SITE, DRUGS
Abstract:RationaleOwing to the widespread abuse of new psychoactive substances (NPSs), developing a rapid, easily operable method to detect NPSs in oral fluid is of high priority. Their ease of collection and non-invasive nature make oral fluid samples suitable for on-site tests and forensic cases. Herein we report a rapid and sensitive method to screen and quantitate 11 new NPSs in oral fluid. MethodsLow-temperature plasma-probe mass spectrometry (LTP-MS) was applied and, to improve the signal intensity, thermally assisted desorption was employed. Tandem mass spectrometry was performed to exclude false positive signals and to decrease noise at the m/z values of interest. ResultsLinearity was studied using matrix-matched calibration curves; all the analytes exhibited good linearity with R-2 varying from 0.9907 to 0.9981. The estimated limits of detection (LODs) were in the range of 3.0-15.2ng/mL, which are comparable to those of immunoassay; relative standard deviations (RSDs) are no greater than 23% at the studied concentration levels. ConclusionsThe proposed LTP-MS-based method was promising in forensic and on-site applications to curb the abuse of NPSs.
Indexed by:Journal paper
Discipline:化学
Document Type:J
Volume:32
Page Number:913-918
ISSN No.:0951-4198
Translation or Not:no
Included Journals:SCI