Main positions:心理健康教育中心专职教师
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Impact Factor:3.038
Affiliation of Author(s):中国科学院大学；中国科学院心理研究所
Teaching and Research Group:中国科学院心理健康重点实验室
Journal:Developmental Psychobiology
Place of Publication:美国
Key Words:embryonic morphine exposure, inhibitory synaptic transmission, medial striatum, opioid, γ-aminobutyricacid
Abstract:Studies of humans, mammalian animals, and chicks reveal that embryonic opioid exposure (EOE) changes the response to pharmacological rewards in postnatal individuals, which may be an outcome of permanent alterations to neural systems. However, the mechanism behind this alteration remains unclear. GABA transmitter has a trophic effect on early GABAergic neuronal development, and EOE decreases GABA concentration in developing brains. Here, we determined whether the development of inhibitory transmission was affected by EOE and whether altered GABA release was the underlying mechanism. We revealed that morphine administration in the early but not the late embryonic period decreased inhibitory transmission in the striatum of chicks. Meanwhile, day-old chicks with early embryonic morphine exposure showed increased psychomotor activity after acute morphine injection compared with saline-exposed chicks. Furthermore, GABA injection in the chick embryo following morphine administration mitigated damage to GABA transmission and recovered the behavioral response to acute morphine injection in chicks. Collectively, our findings suggest that abnormal GABA release in the early embryonic period induced by opioid exposure is attributable to functional and structural developments of the GABA synapse, and that the dysfunction of striatal GABA transmission may be linked to enhanced psychomotor response during initial drug exposure in postnatal life.
First Author:Wen Shang,Zhonghua Dai,Jianjun Zhang,Fang Shen,Nan Sui,Jing Liang
Indexed by:Journal paper
Discipline:Education
First-Level Discipline:Psychology
Volume:64
Issue:e22273
Translation or Not:no
Date of Publication:2022-04-14
Included Journals:SCI
