Embryonicopioidexposureimpairsinhibitorytransmissionof striatuminday-oldchicks
发布时间：2022-04-27
点击次数：
影响因子：3.038
所属单位：中国科学院大学；中国科学院心理研究所
教研室：中国科学院心理健康重点实验室
发表刊物：Developmental Psychobiology
刊物所在地：美国
关键字：embryonic morphine exposure, inhibitory synaptic transmission, medial striatum, opioid, γ-aminobutyricacid
摘要：Studies of humans, mammalian animals, and chicks reveal that embryonic opioid exposure (EOE) changes the response to pharmacological rewards in postnatal individuals, which may be an outcome of permanent alterations to neural systems. However, the mechanism behind this alteration remains unclear. GABA transmitter has a trophic effect on early GABAergic neuronal development, and EOE decreases GABA concentration in developing brains. Here, we determined whether the development of inhibitory transmission was affected by EOE and whether altered GABA release was the underlying mechanism. We revealed that morphine administration in the early but not the late embryonic period decreased inhibitory transmission in the striatum of chicks. Meanwhile, day-old chicks with early embryonic morphine exposure showed increased psychomotor activity after acute morphine injection compared with saline-exposed chicks. Furthermore, GABA injection in the chick embryo following morphine administration mitigated damage to GABA transmission and recovered the behavioral response to acute morphine injection in chicks. Collectively, our findings suggest that abnormal GABA release in the early embryonic period induced by opioid exposure is attributable to functional and structural developments of the GABA synapse, and that the dysfunction of striatal GABA transmission may be linked to enhanced psychomotor response during initial drug exposure in postnatal life.
第一作者：Wen Shang,Zhonghua Dai,Jianjun Zhang,Fang Shen,Nan Sui,Jing Liang
论文类型：期刊论文
学科门类：教育学
一级学科：心理学
卷号：64
期号：e22273
是否译文：否
发表时间：2022-04-14
收录刊物：SCI