Impact of genetic polymorphisms of leptin and TNF-alpha on rosiglitazone response in Chinese patients with type 2 diabetes
关键字：Leptin TNF-α Genetic polymorphism Rosiglitazone Type 2 diabetes
Leptin and tumor necrosis factor-alpha (TNF-alpha) play important role in homeostasis and insulin resistance in the treatment of Type 2 diabetes (T2DM). The aims of the present study were to investigate the association between leptin G-2548A and TNF-alpha G-308A polymorphisms and rosiglitazone response in T2DM patients.
245 patients with T2D and 122 health volunteers were enrolled to identify leptin G-2548A and TNF-alpha G-308A genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Forty-two T2D patients with……
合写作者：Liu ZQ., Zhou HH, Wang D, Zhang W, Yin JY, Hu PC, Gong ZC, Sun H, Wu J, Lin YG, Liu HL1