Rosiglitazone inhibits high glucose-induced apoptosis in human umbilical veinendothelial cells through PI3K/Akt/eNOS pathway
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所属单位:
Department of Endocrinology, Xiang-Ya Hospital, Central South University
教研室:
Department of Endocrinology, Xiang-Ya Hospital, Ce
发表刊物:
Can J Physiol Pharmacol.
刊物所在地:
canada
项目来源:
National Natural Science Foundation of China (No. 30801395)
关键字:
rosiglitazone, PI3K, Akt, eNOS, NO, caspase-3
摘要:
Abstract
Previous studies have shown that the phosphatidylinositol 3-kinase / Akt / endothelial nitric oxide synthase / NO (PI3K/Akt/eNOS/NO) pathway is involved in high glucose-induced endothelial cell apoptosis and rosiglitazone has a protective effect on endothelium. In the present study, we investigated the antiapoptotic effect of rosiglitazone on human umbilical vein endothelial cells (HUVECs) exposed to high glucose and explored its possible mechanism. Treatment of high glucose (33 mmol/L) for 48 h significantly induced the apoptosis of HUVECs, concomitantly with increased caspase-3 ……
论文类型:
基础研究
论文编号:
doi: 10.1139/y09-040
学科门类:
临床医学
文献类型:
J
卷号:
87
期号:
7
页面范围:
549-55
ISSN号:
doi: 10.1139/y09-040
是否译文:
否
附件: