Plasma metabolic profiling of childhood obesity by GC/MS in conjunction with multivariate statistical analysis
所属单位：Central South University
教研室：Research Center of Modernization of Chinese Herba
发表刊物：J Pharm Biomed Anal.
项目来源：International Traditional Chinese Medicine Program for Cooperation in Science and Technol-ogy
关键字：Canonical correlation analysis Childhood obesity Gas chromatography/mass spectrometry Metabolic fing
Metabolic fingerprinting is a powerful tool for exploring systemic metabolic perturbations and potential biomarkers, thus may shed light on the pathophysiological mechanism of diseases. In this work, a new strategy of metabolic fingerprinting was proposed to exploit the disturbances of metabolic patterns and biomarker candidates of childhood obesity. Plasma samples from children with normal weight, overweight and obesity were first profiled by GC/MS. ULDA (uncorrelated linear discriminant analysis) then revealed that the metabolic patterns of the three groups were different.……