KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes
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所属单位:
central South University
教研室:
institute of clinical Pharmacology,
发表刊物:
Clin Pharmacol Ther.
项目来源:
National Major Project of Science and Technology of china grant 2009ZX09304,
摘要:
Abstract
This study showed that the polymorphisms KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) are associated with a heightened risk of developing type 2 diabetes mellitus (T2DM). We also explored the effects of these polymorphisms on the efficacy of repaglinide therapy in Chinese patients with T2DM. A total of 259 patients with T2DM and 188 healthy controls were genotyped. Forty patients with various genotypes were randomly selected to undergo an 8-week repaglinide treatment regimen. Patients with the G allele of the KCNJ11 Lys23Glu polymorphism showed higher levels of fasting plasma glucose ……
论文类型:
基础研究
论文编号:
doi: 10.1038/clpt.2009.242.
学科门类:
基础医学
文献类型:
J
卷号:
87
期号:
3
页面范围:
330-5.
ISSN号:
doi: 10.1038/clpt.2009.242.
是否译文:
否
附件: