NAMPT -3186C ⁄ T polymorphism affects repaglinide response in Chinese patients with Type 2 diabetes mellitus
所属单位：Central South University
教研室：Institute of Clinical Pharmacol- ogy
发表刊物：Clinical and Experimental Pharmacology and Physiol
项目来源：National High-tech R&D Program of 11. China (863 Program; 2009AA022703)
关键字：efficacy, nicotinamide phosphoribosyltransferase, polymorphism, repaglinide, Type 2 diabetes.
1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy controls were genotyped for NAMPT-948G>T and -3186C>T polymorphisms. Thirty-five patients with different NAMPT -3186 C/T genotypes and the same organic anion-transporting polypeptide 1B1 (OATP1B1521) T/C genotype were randomly selected to undergo 8 weeks preprandial ……