Dysregulated mTOR-Dependent Signaling in Neurodegeneration or Carcinogenesis:Implication for Alzheimer’s Disease and Brain Tumors.J Alzheimers Dis.
点击次数:
所属单位:
Central South University
教研室:
Department of Endocrinology,
发表刊物:
J Alzheimers Dis.
项目来源:
National Natu- ral Science Foundation of China (No. 81170754 and 81001107).
关键字:
Alzheimer’s disease, carcinogenesis, mTOR, neurodegeneration
摘要:
Abstract
Recent evidence implicated aberrant mammalian target of rapamycin (mTOR)-dependent signaling in both Alzheimer's disease (AD) and brain tumors. This review focuses on the potential mechanisms shared by both neurodegeneration and carcinogenesis. In particular, attention was paid to the possible roles of mTOR-dependent signaling in these two fundamental pathophysiological processes. We hypothesize that common stresses could lead either to progressive degeneration or uncontrolled carcinogenesis via cell type specific upregulation of mTOR-dependent signaling in the central nervous system
论文类型:
基础研究
论文编号:
doi: 10.3233/JAD-130641.
学科门类:
基础医学
文献类型:
J
卷号:
37
期号:
3
页面范围:
495-505
ISSN号:
1387-2877/13/$27.50 ? 2013
是否译文:
否
附件: