nflammation-induced microvascular insulin resistance is an early event in diet-induced obesity
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所属单位：
University of Virginia Health System
教研室：
Division of Endocrinology and Metabolism
发表刊物：
Clin Sci (Lond).
项目来源：
the American Diabetes Association [grant numbers 1-11-CR-30 and 1-15-CE-32 (to Z.L.)]
关键字：
endothelial dysfunction; high-fat diet; inflammation; insulin resistance; muscle microvasculature; o
摘要：
Abstract
Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance and metabolic insulin resistance. We assessed insulin responses in all arterial segments, including aorta, distal saphenous artery and the microvasculature, as well as the metabolic insulin responses in muscle in rats fed on a high-fat diet (HFD) for various durations ranging from 3 days to 4 weeks with or without sodium salicylate treatment. Compared with controls……
论文类型：
基础研究
论文编号：
doi: 10.1042/CS20150143.
学科门类：
基础医学
文献类型：
J
卷号：
129
期号：
12
页面范围：
1025-36
ISSN号：
doi: 10.1042/CS20150143.
是否译文：
否
附件：
学位：博士学位
职称：教授
学科：临床医学
所在单位：中南大学湘雅医院