Role of non-coding RNAs and RNA modifiers in cancer therapy resistance

Release time:2020-07-11

Impact Factor:5.134

Affiliation of Author(s):中南大学

Teaching and Research Group:病理学系

Journal:Mol Cancer

Key Words:ncRNAs, RNA modifiers, Chemoresistance, Radioresistance

Abstract:As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and scientific research, resulting in tumor recurrence and metastasis. The mechanisms of therapy resistance are complicated and result from multiple factors. Among them, non-coding RNAs (ncRNAs), along with their modifiers, have been investigated to play key roles in regulating tumor development and mediating therapy resistance within various cancers, such as hepatocellular carcinoma, breast cancer, lung cancer, gastric cancer, etc. In this review, we attempt to elucidate the mechanisms underlying ncRNA/modifier-modulated resistance to chemotherapy and radiotherapy, providing some therapeutic potential points for future cancer treatment.

Co-author:Kai Xie, Honghua Zhou, Yuwei Wu, Chan Li, Yating Liu, Zhaoya Liu, Qian Xu

First Author:Xinyi Zhang

Indexed by:Journal paper

Correspondence Author:,Shuang Liu, Desheng Xiao, Yongguang Tao

Discipline:基础医学

Document Type:J

Volume:19(1)

Page Number:47

Translation or Not:no

Date of Publication:2020-01-01

Included Journals:SCI