The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

Release time:2020-07-11

Impact Factor:5.134

Affiliation of Author(s):中南大学

Teaching and Research Group:病理学系

Journal:Mol Cancer

Key Words:Ferroptosis, Epigenetics, Cancer, Organelles, Chromatin remodeling factor, lncRNA, Golgi, Lysosome, Endoplasmic reticulum, Mitochondria, Metabolism, Iron, Lipid peroxidation, Immunotherapy

Abstract:Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name a few. Here we summarize current literature on ferroptosis, including organelle dysfunction, signaling transduction pathways, metabolic reprogramming and epigenetic regulators in cancer progression. With regard to organelles, mitochondria-induced cysteine starvation, endoplasmic reticulum-related oxidative stress, lysosome dysfunction and golgi stress-related lipid peroxidation all contribute to induction of ferroptosis. Understanding the underlying mechanism in ferroptosis could provide insight into the treatment of various intractable diseases including cancers.

Co-author:Siwei Zhang, Xiaoxiao Gong, Samantha Tam

First Author:Yuqing Wu

Indexed by:Journal paper

Correspondence Author:Desheng Xiao, Shuang Liu, Yongguang Tao

Discipline:基础医学

Volume:19(1)

Page Number:39

Translation or Not:no

Date of Publication:2020-02-27

Included Journals:SCI