Primary gastric malignant melanoma might originate from amine precursor uptake and decarboxylation cells
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Release time:2020-07-12
Affiliation of Author(s):中南大学
Teaching and Research Group:病理学系
Journal:Int J Clin Exp Pathol
Key Words:Stomach, primary, malignant melanoma, amine precursor uptake and decarboxylation cells
Abstract:Primary gastric malignant melanoma is a rare malignant tumor. The purpose of this study is to determine the origination of primary gastric malignant melanoma. We report a case of a 63-year-old male with a history of right limb movement disorder for one month. The patient underwent microscopic supratentorial mass resection and proximal stomach resection. Hematoxylin-eosin and immunohistochemical staining, amplification refractory mutation system analysis and transmission electron microscopy test were performed. Hematoxylin-eosin staining showed diffuse patchy distribution of tumor cells, the pleomorphism, epithelioid or fusiform, abundant cytoplasm, increased mitotic figures, and obvious melanin particles. Immunohistochemical results indicated positive expression for S-100, HMB45, Melan-A, CD56, NSE, Syn, CgA, Vimentin and bcl-2, and negative expression for CK-Pan, CD117, Dog-1, CD34, Desmin, Actin-ping, HHF35, MBP. BRAF V600E mutation was detected in primary gastric malignant melanoma. The neurosecretory granules were observed in the cytoplasm of melanoma cells. Pathological examination finally made a definite diagnosis of primary malignant melanoma, serosa layer and perigastric lymph nodes involved (1/20), with the left parietal lobe metastasis. Immunohistochemical and transmission electron microscopy test results indicated that primary gastric malignant melanoma might originate from amine precursor uptake and decarboxylation cells.
Co-author:Bin Xie, Yumei Duan, Weiping Su, Xiaoping Yi, Wei Liu, Chunyan Fu, Yongguang Tao, Jianhua Zhou
First Author:Yangying Zhou
Indexed by:Journal paper
Correspondence Author:Desheng Xiao
Issue:9(12)
Page Number:13003-13009
Translation or Not:no
Date of Publication:2016-12-15
Included Journals:SCI
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