学位：博士学位
学历：研究生(博士)毕业
职称：教授
所在单位：基础医学院
学术荣誉： 曾获荣誉：
中南大学教授，博士生/博士后导师，现任中南大学基础医学院病理学系/湘雅医院病理科副主任、分子病理诊断中心主任。病理学国家级精品课程主讲教师、病理学国家级资源共享课程主讲教师及基础医学形态学国家级教学团队、卫计委临床重点专科骨干成员，副主编及参编《病理学》全国高等学校医学规划教材及配套教材7本，人民卫生出版社国家医学教育题库病理学学科副主编，获校级教学成果奖8项；参与或主持了教育部教改项目、教育部修购专项资助项目、教育部985资助项目、国家自然科学基金及湖南省科技计划项目10项。发表本专业SCI论文90余篇。获湖南省自然科学奖三等奖一项。
Desheng Xiao, Ph.D., professor, PhD candidate/post-doctoral supervisor, Deputy Director of Department of Pathology, Basic Medical School/Xiangya Hospital, Central South University, Director of Molecular Pathology Diagnosis Center. The main teacher of national excellent pathology course and national resource sharing course, the national teaching team of basic medical Morphology, and the main member of National Health and Family Planning Commission key clinical specialty. Presided over or participated in 10 projects of national Natural Science Foundation of China and Natural Science Foundation of Hunan Province. Won the third prize of Natural Science award of Hunan Province (ranked the third). Published more than 90 SCI papers in this field. Concurrently hold the molecular pathology group member of the Chinese medical doctor association pathology branch, a member of the standing committee of the China medical equipment AI union pathology committee, the incoming chairman of hunan province medical association pathology professional committee, the chairman of hunan medical association pathology professional committee Younger Committee, the vice president of Hunan Medical Doctor Association Pathologist Branch, the vice director of hunan Clinicopathological Quality Control Center, a member of Hunan Anti-cancer Association Lung Cancer Professional Committee. and a review expert of the National Natural Science Foundation of China.
Primary gastric malignant melanoma might originate from amine precursor uptake and decarboxylation cells
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所属单位：中南大学
教研室：病理学系
发表刊物：Int J Clin Exp Pathol
关键字：Stomach, primary, malignant melanoma, amine precursor uptake and decarboxylation cells
摘要：Primary gastric malignant melanoma is a rare malignant tumor. The purpose of this study is to determine the origination of primary gastric malignant melanoma. We report a case of a 63-year-old male with a history of right limb movement disorder for one month. The patient underwent microscopic supratentorial mass resection and proximal stomach resection. Hematoxylin-eosin and immunohistochemical staining, amplification refractory mutation system analysis and transmission electron microscopy test were performed. Hematoxylin-eosin staining showed diffuse patchy distribution of tumor cells, the pleomorphism, epithelioid or fusiform, abundant cytoplasm, increased mitotic figures, and obvious melanin particles. Immunohistochemical results indicated positive expression for S-100, HMB45, Melan-A, CD56, NSE, Syn, CgA, Vimentin and bcl-2, and negative expression for CK-Pan, CD117, Dog-1, CD34, Desmin, Actin-ping, HHF35, MBP. BRAF V600E mutation was detected in primary gastric malignant melanoma. The neurosecretory granules were observed in the cytoplasm of melanoma cells. Pathological examination finally made a definite diagnosis of primary malignant melanoma, serosa layer and perigastric lymph nodes involved (1/20), with the left parietal lobe metastasis. Immunohistochemical and transmission electron microscopy test results indicated that primary gastric malignant melanoma might originate from amine precursor uptake and decarboxylation cells.
合写作者：Bin Xie, Yumei Duan, Weiping Su, Xiaoping Yi, Wei Liu, Chunyan Fu, Yongguang Tao, Jianhua Zhou
第一作者：Yangying Zhou
论文类型：期刊论文
通讯作者：Desheng Xiao
期号：9(12)
页面范围：13003-13009
是否译文：否
发表时间：2016-12-15
收录刊物：SCI
