学位：博士学位
学历：研究生(博士)毕业
职称：教授
所在单位：基础医学院
学术荣誉： 曾获荣誉：
中南大学教授，博士生/博士后导师，现任中南大学基础医学院病理学系/湘雅医院病理科副主任、分子病理诊断中心主任。病理学国家级精品课程主讲教师、病理学国家级资源共享课程主讲教师及基础医学形态学国家级教学团队、卫计委临床重点专科骨干成员，副主编及参编《病理学》全国高等学校医学规划教材及配套教材7本，人民卫生出版社国家医学教育题库病理学学科副主编，获校级教学成果奖8项；参与或主持了教育部教改项目、教育部修购专项资助项目、教育部985资助项目、国家自然科学基金及湖南省科技计划项目10项。发表本专业SCI论文90余篇。获湖南省自然科学奖三等奖一项。
Desheng Xiao, Ph.D., professor, PhD candidate/post-doctoral supervisor, Deputy Director of Department of Pathology, Basic Medical School/Xiangya Hospital, Central South University, Director of Molecular Pathology Diagnosis Center. The main teacher of national excellent pathology course and national resource sharing course, the national teaching team of basic medical Morphology, and the main member of National Health and Family Planning Commission key clinical specialty. Presided over or participated in 10 projects of national Natural Science Foundation of China and Natural Science Foundation of Hunan Province. Won the third prize of Natural Science award of Hunan Province (ranked the third). Published more than 90 SCI papers in this field. Concurrently hold the molecular pathology group member of the Chinese medical doctor association pathology branch, a member of the standing committee of the China medical equipment AI union pathology committee, the incoming chairman of hunan province medical association pathology professional committee, the chairman of hunan medical association pathology professional committee Younger Committee, the vice president of Hunan Medical Doctor Association Pathologist Branch, the vice director of hunan Clinicopathological Quality Control Center, a member of Hunan Anti-cancer Association Lung Cancer Professional Committee. and a review expert of the National Natural Science Foundation of China.
Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC
点击次数：
影响因子：5.177
发表刊物：Am J Cancer Res
关键字：AhR; BaP; SMARCA6; lung cancer; smoking
摘要：Recent studies suggest that individual subunits of chromatin-remodeling complexes generate epigenetically specific signaling in tumorigenicity. The impact of environmental factors on the chromatin-remodeling factor has not been thoroughly elucidated to date. We detected the expression level of SMARCA6 (SWI/SNF2-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 6) in NSCLC (Non-small-cell lung carcinoma) and measured it through quantitative real-time PCR (qRT-PCR) and immunohistochemistry. The effects of BaP on proliferation and cell cycle progression were evaluated using MTT, colony formation and FACS analyses. Tumor growth in vivo was observed in a xenograft model. ChIP and qPCR were performed to validate that SMARCA6 was a potential target of AhR in NSCLC. As a result, BaP increased SMARCA6 expression. Smoking was linked with elevated SMARCA6 expression in NSCLC. BaP promoted cancer progression in vitro and in vivo. ChIP assay confirmed that BaP increases SMARCA6 expression via recruitment of AhR and induces SMARCA6 expression by facilitating AhR translocation to the nucleus. Furthermore, inhibition of AhR expression decreases SMARCA6 expression in NSCLC. Finally, knockdown of SMARCA6 attenuates BaP-induced cancer progression. This study demonstrates that BaP promotes proliferation by activation of AhR, which promotes SMARCA6 expression, and may identify new diagnostic and therapeutic targets in lung cancer.
合写作者：Min Wang, Banglun Qian, Lianlian Ouyang, Ying Shi, Na Liu, Ling Chen, Desheng Xiao, Xiang Wang, Ya Cao, Wenliang Liu
第一作者：Chao Mao
通讯作者：Shuang Liu, Yongguang Tao
卷号：8(7)
页面范围：1214-1227
是否译文：否
发表时间：2018-07-01
收录刊物：SCI
