中文
  • 殷刚
  • Doctoral degree
  • Researcher
  • 特聘研究员
  • Basic Medical Sciences
 

Educational Background

  • 2001.92006.6

     上海复旦大学   遗传学专业   Doctoral degree   PhD Graduate 

Work Experience

  • 2012.7Now

    中南大学      基础医学院/湘雅医院    基础医学院副院长    研究员    全职

  • 2010.112012.7

    美国耶鲁大学      医学院    青年PI

  • 2008.62010.11

    美国耶鲁大学      医学院    博士后

  • 2006.102008.6

    美国明尼苏达大学医学院      博士后

Research Group

  • Name of Research Group:中南大学基础医学院病历系 殷刚老师课题组

    Description of Research Group:殷刚老师团队现教授1人、临床主任医师1人、副教授2人、实验师1人、博士后2人、博士生8人、硕士生6人、长期参与文献分享课题讨论的本科生有10人左右。

Social Affiliations

  • 湖南省抗癌协会委员

  • 中国民主同盟湖南省第十四次代表大会委员会委员

  • 湖南省神经科学学会神经干细胞工程专业委员会副主任委员

  • 湖南抗癌协会癌症病因学专业委员会副主任委员

  • 中国抗癌协会肿瘤营养与支持治疗专业委员会精准肿瘤营养学组委员

  • 美国耶鲁大学客座副教授

  • 国家教育部专家库成员。国家科技部专家库成员。国家自然科学基金一审专家。

  • 受邀作为著名SCI期刊审稿人。

  • 受聘为2016年到2017年《Cancer Translational Medicine》编委。
    受聘为中国抗癌协会肿瘤营养与支持治疗专业委员会肿瘤代谢祝青年委员会组长。
    受邀作为著名SCI期刊审稿人。
    “中俄医科大学联盟青年联盟”副主席。
    湖南省欧美同学会常务理事。
    国家教育部专家库成员。国家科技部专家库成员。
    国家自然科学基金一审专家

  • 受聘为中国抗癌协会肿瘤营养与支持治疗专业委员会肿瘤代谢祝青年委员会组长。

  • “中俄医科大学联盟青年联盟”副主席。

  • 湖南省欧美同学会常务理事。

 

Personal Information

Gang Yin, Ph.D.
Professor/Vice Dean: School of Basic MedicineCentral South University

172 TongZiPo Rd. Bldg of Pathology Rm210, Changsha, Hunan, China 410013 Phone: 86-731-82650413; Email: gang.yin@csu.edu.cn

Education:
2006 Ph.D. 
in Molecular Genetics, Fudan University, Shanghai, China 2000 B.S. in Biology, Inner Mongolia University, Huhhot, China

Research Experience:
Ø 12/13~present Professor/Vice Dean School of Basic Medicine,

Central South University
Ø 7/12~11/13 Professor Dept. of Pathology, School of

Basic Medicine, Central South University.

Research Projects:

1. Study the molecular mechanisms of cancer stem cell differentiation and metastasis
2. Study the functions of exosome in cancer cell properties such as EMT, metastasis, chemoresistance and immune response in normoxia or hypoxia.

Ø 11/10~7/12 Associate Research Scientist.OBGYN, School of Medicine, Yale Univ. New Haven, CT, USA

Research projects:

1) Study the molecular mechanisms of Twist1 in regulating ovarian cancer stem cell differentiation and metastasis

2) StudythemechanismofmicroRNA-199/214affectingtheepithelialovarian cancer stem cells differentiation and chemoresistance.

Ø 06/08~11/10 Postdoctoral Associate. OBGYN, School of Medicine, Yale Univ. New Haven, CT, USA

Research projects:

1) Study the molecular mechanisms of Twist1 in regulating ovarian cancer stem cell differentiation and acquisition of metastatic capacity
2) Study the mechanism of microRNA-221/222 affecting the PI3K/AKT pathway in ovarian cancer

3) Study the multipotency of Ovarian cancer stem-like cells

Ø 11/06~06/08 Postdoctoral Associate. Cardiovascular Division, Department of Medicine, Univ. of Minnesota, Minneapolis, MN, USA

Research projects:

1) Investigate the cellular and molecular mechanism of AMP-activated protein kinase (AMPK) function involved in atherosclerosis by using human

page1image35206848 page1image35197056 page1image35194752

1

umbilicalvein endothelial cells (HUVEC)
2) Study the function of Core2-belta-1,6-N-acetylglucosaminyltransferase

(Core2GlcNAcT-1) in thrombosis and atherosclerosis by using leukocytes

Ø 2001~2006 Ph.D. graduate student Genetic Institute, Life science School, Fudan Univ. China

Research projects:

1) CloningandCharacterizationofanovelhumanubiquitin-conjugatingenzyme: hUBC16

2) StudythefunctionofahumanGlutathionePeroxidase7gene(hGPx7)incell signaling pathways

Awards and Memberships

2011- present Adjunct Professor, School of Medicine, Xi'an Jiaotong University

2009 - present Member, American Association of Cancer Research 2006 FUDAN outstanding student award, Fudan University
2005 
hp Award, China Scholarship Council & HP company
2005 
Xie-Xide Award, Fudan University

page2image35350464

2005 Re-dian Award, Fudan University & Re-dian Company 2004 First Prize Graduate Scholarship, Fudan University 2003 Second Prize Graduate Scholarship, Fudan University 2002 Third Prize Graduate Scholarship, Fudan University

Research support

1) National Natural Science Foundation of China (550,000 Yuan) 12/2025

Role: PI

2) National Natural Science Foundation of China (682,000 Yuan) 12/2019

Title: The Role of miR-199a Inhibiting Differentiation Potential of Epithelial Ovarian Cancer Stem Cells to Tumor Vascular Progenitors Role: PI

01/2022-

01/2016-

page2image35354496 page2image35352384

Title: Ovarian Cancer Stem-Like cells-derived Exosome Improves Non-Stem Cancer cells Proliferation and Migration through Hotair/miR-222/CDK19 Axis

3) Natioal Natural Science Foundation of China –Young Scientist(230,000 Yuan) 01/2013-12/2015

Title: The Role of miR-199a Inhibiting Ovarian Cancer Stem Cells Chemoresistance Capacity

Role: PI

2

4) Sands Foundation (50,000$), 7/2011-6/2012 Title: In Vivo Model for Targeting Ovarian Cancer Stem Cells
Role: PI

5) The Honorable Tina Brozman Foundation(100,000$), 11/2010-06/2011 Title: Early Detection of Ovarian Cancer
Role
PI

6) R01 NIH(1,660,000), 7/2008-5/2012 Title:MyD88-Bearing Tumors in Immune-regulation and Chemo-resistance

Role: Postdoctoral Associate

7) Burros Family Foundation (400,000$), Title: Ovarian Cancer Research
Role: Postdoctoral Associate

8) The Discovery to Cure Program (2,500,000$),
Title: Early Detection and Treatment for Ovarian Cancer Role: Postdoctoral Associate

Reviewer experience:

Reproductive SciencesTheranostics, Oncogene

8/12009-7/2010

8/13/2008-7/31/2009

page3image35145024

Publications:

  1. 1)  Lili Fan, Han Lei, Ying Lin, Zhengwei Zhou, Guang Shu, Zhipeng Yan, Haotian Chen, Tianxiang Zhang,

    Gang Yin*.(2021) Identification of a Gene Set Correlated With Immune Status in Ovarian Cancer by Transcriptome-Wide Data Mining. Frontiers in Molecular Biosciences. (JCR分区: Q2) 2021 July 30; https://doi.org/10.3389/fmolb.2021.670666. (IF=5.246)

  2. 2)  Gang Yin*.

    (JCR分区: Q2)

  3. 3)  Jiaxin Liu, Yimin Li, Yaqi Gan, Qing Xiao, Ruotong Tian, Guang Shu, Gang Yin*.(

    (JCR 分区: Q1) page3image3514675211; doi: 10.3389/fcell.2021.671211.

  4. 4)  Xiao Q, Gan Y, Li Y, Fan L, Liu J, Lu P, Liu J, Chen A, Shu G, Yin G*. (2021) MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression. Oncogene. (JCR 分区: Q1) 2021 May;40(19):3364-3377. doi: 10.1038/s41388-021-01774-w. Epub 2021 Apr 16. PMID: 33863999. (IF=9.479)

  5. 5)  Huang WL, Abudureheman T, Xia J, Chu L, Zhou H, Zheng WW, Zhou N, Shi RY, Li MH, Zhu JM, Qing K, Ji C, Liang KW, Guo S, Yin G*, Duan CW*. CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism. Frontiers in Cell and Developmental Biology (JCR 分区: Q1) 2021 Mar 4;9:641271. doi: 10.3389/fcell.2021.641271. PMID: 33748130. (IF=6.536)

  6. 6)  Fan L, Lin Y, Lei H, Shu G, He L, Yan Z, Rihan H, Yin G*. (2020)A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer. Aging (Albany NY). (JCR 分区: Q1) 2020 Sep 20;12(18):18453-18475. doi: 10.18632/aging.103811. Epub ahead of print. PMID: 32950970; PMCID: PMC7585096.

page3image35159040 page3image35153280 page3image35152128 page3image35131520 page3image35261632

7)

Rihan Hai, Liuer He, Guang Shu and

(JCR 分区: Q1)

3

(2021). Characterization of Histone Deacetylase

page3image35273536 page3image35268544 page3image35274496

Mechanisms in Cancer Development. Frontiers in oncology

2021 Jul 29; doi:

page3image35262016

10.3389/fonc.2021.70094 (IF=6.244)

page3image35273728

2021)Identification of

page3image35266048 page3image35274304

ZNF26 as a prognostic biomarker in colorectal cancer by an integrated bioinformatic analysis. Frontiers

page3image35318080

in Cell and Developmental Biology.

2021 Jun

page3image35318464

(IF=6.536)

page3image35316544

(IF=5.531)

page3image35311168 page3image35317504

Peng Y, Li Y, Li Y, Wu A, Fan L, Huang W, Fu C, Deng Z, Wang K, Zhang Y, Shu G*

HOXC10 promotes tumour metastasis by regulating the EMT-related gene Slug in ovarian cancer. Aging

Yin G*. (2020)

page3image35318848 page3image35329664 page3image35372608page3image35356672

(Albany NY).

2020 Sep 7;12(19):19375-19398. doi: 10.18632/aging.103824. PMID:

page3image35519296

32897245.(IF=5.531)

Li Y, Liu J, Xiao Q, Tian R, Zhou Z, Gan Y, Li Y, Shu G*

Yin G*. (2020) EN2 as an oncogene promotes

tumor progression via regulating CCL20 in colorectal cancer. Cell Death Dis.

30;11(7):604. doi: 10.1038/s41419-020-02804-3. PMID: 32732864 (IF=8.105)

Wu A, Zhang S, Liu J, Huang Y, Deng W, Shu G, Yin G*. (2020) Integrated Analysis of Prognostic and

2020 Jul

Immune Associated Integrin Family in Ovarian Cancer. Front Genet.

2020 Jul 17;11:705.

doi: 10.3389/fgene.2020.00705. PMID: 32765584.(IF=4.417)

Li J, Alvero AB, Nuti S, Tedja R, Roberts CM, Pitruzzello M, Li Y, Xiao Q, Zhang S, Gan Y, Wu X, Mor G

Yin G*. (2020)CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic

potential. Oncogene.

2020 May;39(20):3965-3979. doi: 10.1038/s41388-020-1269-5.

PMID: 32205869.(IF=9.479)

Fan L, Lei H, Zhang S, Peng Y, Fu C, Shu G,Yin G*. (2020) Non-canonical signaling pathway of SNAI2

induces EMT in ovarian cancer cells by suppressing miR-222-3p transcription and upregulating PDCD10.

Theranostics.

32483426. (IF=11.556)

2020 Apr 27;10(13):5895-5913. doi: 10.7150/thno.43198. PMID:

He L, Li H, Wu A, Peng Y, Shu G,Yin G*. (2019) Functions of N6-methyladenosine and its role in cancer.

Mol Cancer.

2019 Dec 4;18(1):176. doi: 10.1186/s12943-019-1109-9. PMID:

31801551.(IF=27.401)

Li T, Zhou W, Li Y, Gan Y, Peng Y, Xiao Q, Ouyang C, Wu A, Zhang S, Liu J, Fan L, Han D, Wei Y, Shu

G, Yin G*. (2019)MiR-4524b-5p/WTX/β-catenin axis functions as a regulator of metastasis in cervical

cancer. PLoS One.

(JCR 分区: Q2)

2019 Apr 2;14(4):e0214822. doi: 10.1371/journal.pone.0214822.

Erratum in: PLoS One. 2019 Dec 17;14(12):e0226864. PMID: 30939162.(IF=3.117)

Li T, Li Y, Gan Y, Tian R, Wu Q, Shu G, Yin G*. (2019) Methylation-mediated repression of MiR-424/503

cluster promotes proliferation and migration of ovarian cancer cells through targeting the hub gene KIF23.

Cell Cycle.

(JCR 分区: Q2)

2019 Jul;18(14):1601-1618. doi: 10.1080/15384101.2019.1624112. Epub

2019 Jun 9. PMID: 31135262.(IF=4.286)

Wu Q, Ren X, Zhang Y, Fu X, Li Y, Peng Y, Xiao Q, Li T, Ouyang C, Hu Y, Zhang Y, Zhou W, Yan W, Guo

K, Li W, Hu Y, Yang X, Shu G, Xue H, Wei Z, Luo Y, Yin G*. (2018) MiR-221-3p targets ARF4 and inhibits

the proliferation and migration of epithelial ovarian cancer cells. Biochem Biophys Res Commun.

2018 Mar 18;497(4):1162-1170. doi: 10.1016/j.bbrc.2017.01.002. Epub 2017 Jan 3. PMID:

28057486. (IF=3.426)

Gan Y, Li Y, Li T, Shu G, Yin G*. (2018)CCNA2 acts as a novel biomarker in regulating the growth and

apoptosis of colorectal cancer. Cancer Manag Res.

2018 Oct 31;10:5113-5124. doi:

10.2147/CMAR.S176833. PMID: 30464611.(IF=3.861)

Wu, A. , Shu, G. , Wang, J. , & Yin, G*. (2017)Targets and beyond: cancer stem cell elimination. Science

Bulletin,

(JCR 分区: Q1)

62(16):1104-1105.(IF=11.780)

Fu X, Li Y, Alvero A, Li J, Wu Q, Xiao Q, Peng Y, Hu Y, Li X, Yan W, Guo K, Zhou W, Wang Y, Liu J, Zhang

Y, Mor G, Wen J, Yin G*. (2016) MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival. Oncotarget. 2016 Dec 6;7(49):80633-80654. doi:

10.18632/oncotarget.13017. PMID: 27811362.(IF=5.008)

Zhou W, Yang X, Dai Y, Wu Q, He G, Yin G*. (2016) Survey of cervical cancer survivors regarding quality

of life and sexual function. J Cancer Res Ther.

2016 Apr-Jun;12(2):938-44. doi:

10.4103/0973-1482.175427. PMID: 27461678.(IF=1.329)

Nuti, S. V., Mor, G., Li, P., & Yin, G*. (2014). Twist and ovarian cancer stem cells: implications for

chemoresistance and metastasis. Oncotarget, 5(17), 7260. (IF=5.008)

Yin, G., Alvero, A. B., Craveiro, V., Holmberg, J. C., Fu, H. H., & Montagna, M. K., et al. (2012).

Constitutive proteasomal degradation of twist-1 in epithelial ovarian cancer stem cells impacts

differentiation and metastatic potential. Oncogene, 32(1), 39.(IF=7.932)

Liu M, Mor G, Cheng H, et al. High Frequency of Putative Ovarian Cancer Stem Cells With CD44/CK19

Coexpression Is Associated With Decreased Progression-Free Intervals In Patients With Recurrent

Epithelial Ovarian Cancer[J]. Reproductive Sciences, 2013, 20(5):605-15.

Yin, G., Chen, R., Alvero, A. B., Fu, H. H., Holmberg, J., & Glackin, C., et al. (2009). Twisting stemness,

inflammation and proliferation of epithelial ovarian cancer cells through mir199a/214. Oncogene,29(24),

3545. (IF=7.932)

Yin, G., Craveiro, V., Holmberg, J., Fu, H. H., Alvero, A., & Mor, G. (2010). Epithelial-mesenchymal

transition generates cancer stem cells with metastatic potential. Reproductive Sciences 2010 Mar 17(3):

111A-111A. (IF=2.429)

Mor, G., Yin, G., Chefetz, I., Yang, Y., & Alvero, A. (2011). Ovarian cancer stem cells and

inflammation. Cancer Biology & Therapy, 11(8), 708. (IF=2.921)

Yin, G., Ji, C., Zeng, L., Wang, Z., Wang, J., & Shen, Z., et al. (2006). Cloning and characterization of a

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21222324)

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(JCR 分区: Q1) (JCR 分区: Q2)

(JCR 分区: Q1)

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4

(JCR 分区: Q3)

(JCR分区: Q1) (JCR分区: Q4)

(JCR

*,

novel krab-domain-containing zinc finger gene (znf284l). Molecular Biology Reports, 33(2), 137-144.

(IF=1.698)

Yin, G., Ji, C., Wu, T., Shen, Z., Xu, X., & Xie, Y., et al. (2006). Cloning, characterization and subcellular

localization of a gene encoding a human ubiquitin-conjugating enzyme (e2) homologous to the

arabidopsis thaliana ubc-16 gene product. Frontiers in Bioscience, 11(10), 1500. (IF=2.484)

Wu M, Yin G (co-first author), Zhao X, Ji C, Gu S, Tang R, Dong H, Xie Y, Mao Y. (2006).Human RAB24,

2728)

interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A 29)

3031)

and GABARAP. Int J Mol Med,17(5): 749-754. (IF=2.348)

Yin, G., Dai, J. L., Ji, C., Ni, X., Shu, G., & Ye, X., et al. (2003). Cloning and characterization of the human

ift20 gene *. Molecular Biology Reports, 30(4), 255-60. (IF=1.698)

Chen J, Yin G (co-first author), Lu Y, Lou M, Cheng H, Ni X, Hu G, Luo C, Ying K, Xie Y, Mao Y. (2004).

Cloning and characterization of a novel human cDNA encoding a J-domain protein (DNAJA5) from the

fetal brain. Int J Mol Med. 13(5):735-740. (IF=2.348)

Ye, X., Ji, C., Yin, G., Tang, R., Zeng, L., & Gu, S., et al. (2004). Characterization of a human sec14-like

protein cdna sec14l3 highly homologous to human spf/tap. Molecular Biology Reports, 31(1), 59-63.

(IF=1.698)


  • Researcher
    Supervisor of Doctorate Candidates
    Supervisor of Master's Candidates
  • Date of Employment:2012-07-05
  • School/Department:Basic Medical Sciences
  • Administrative Position:特聘研究员
  • Education Level:PhD Graduate
  • Business Address:湘雅新校区病理楼208室或湘雅新校区教学楼后栋三楼基础医学院副院长办公室
  • Sex:Male
  • Contact Information:0731-82650413或0731-82650342
  • Degree:Doctoral degree
  • Status:Employed
  • Academic Titles:中南大学基础医学院副院长 中南大学基础医学院病理系 教授 博士生导师 中南大学基础医学院青年科协主席
  • Alma Mater:上海复旦大学
  • Discipline:Basic Medicine
  • Honors and Titles:
  • 被评为中南大学531人才,担任2016年到2017年《Cancer Translational Medicine》编委。现任中南大学基础医学院副院长,基础医学院病理系教授,博士生导师,美国癌症协会会员,美国耶鲁大学客座副教授和高级访问教授。西安交通大学客座教授,国家教育部专家库成员,国家科技部专家库成员,科技部创新人才推进计划(万人计划)二审专家。出任2017年《转化医学电子杂志》编辑委员会第二届委员,“中俄医科大学联盟青年联盟”副主席。兼任中国抗癌协会肿瘤营养与支持治疗专业委员会肿瘤代谢组青年委员会组长;
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