Regulation of cellular iron metabolism and its implications in lung cancer progression

Release time:2016-04-25

Journal:Medical oncology

Abstract:Iron is essential for life and is involved in numerous metabolic processes including cell growth and proliferation. However, excess iron in the body raises the risk of developing cancer due to its capacity to engage in redox cycling and free radical production. Therefore, iron can contribute to both carcinogenesis and tumor growth. Both epidemiologic and laboratory studies have demonstrated that the effects of iron overload are associated with the tumorigenesis of lung cancer and growth of lung cancer cells. In particular, the discovery of hepcidin and several iron transporters in the past

Note:decade may warrant reconsideration of the role of iron in carcinogenesis and tumor cell proliferation in lung cancer. Pathways of iron uptake, storage, efflux, and regulation are all disturbed in cancer, suggesting that reprogramming of iron metabolism is a critical aspect of tumor cell survival.

Co-author:F., L.; Yu, W.; Wang, Xiong

Indexed by:Unit Twenty Basic Research

Discipline:临床医学

Document Type:J

Issue:2014, 31 (7),

Page Number:28

Translation or Not:no