Biological properties of carbon/carbon implant composites with unique manufacturing processes

Release time:2021-07-17

Affiliation of Author(s):中南大学

Journal:JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Key Words:Flexural Strength，Extract Liquid，Negative Control Group，Positive Control Group，Micronucleus Assay

Abstract:The goal was to manufacture carbon/carbon (C/C) composites through a unique procedure with improved biocompatibility and reduced debris release. C/C composites were prepared by chemical vapor deposition, and their biological properties were analyzed. With regard to mechanical properties, compressive strength/modulus was 219.1 MPa/9.72 GPa, flexural strength/modulus was 121.63 MPa/21.9 GPa, and interlaminar sheer was 15.13 GPa. Biocompatibility testing revealed: (1) the extract liquid from the C/C composites had no effect on cell proliferation; (2) the extract had no impact on micronucleus frequency as compared with the control groups (P > 0.05); (3) in vivo, there was mild tissue inflammation after implantation within the first 2 weeks, but there was no significant difference compared with the control group (P > 0.05); (4) the implants were well integrated into the host tissue, and debris was limited. The tested samples have excellent biocompatibilities and reduced release of debris. The demonstrated changes in manufacturing procedures are promising

Indexed by:Article

Discipline:Engineering

First-Level Discipline:Materials Science and Engineering

Document Type:J

Volume:20

Issue:12

Page Number:2487-2492

Translation or Not:no

Date of Publication:2009-12-24

Included Journals:SCI